scholarly journals Higher expression of cell division cycle-associated protein 5 predicts poorer survival outcomes in hepatocellular carcinoma

Aging ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 14542-14555
Author(s):  
Shengzhong Hou ◽  
Xing Chen ◽  
Mao Li ◽  
Xing Huang ◽  
Haotian Liao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Cell Division Cycle ◽  
Survival Outcomes

scholarly journals Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma

2021 ◽  
Author(s):  
Xiao‐Han Cui ◽  
Qiu‐Ju Peng ◽  
Ren‐Zhi Li ◽  
Xia‐Jie Lyu ◽  
Chun‐Fu Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Prognostic Biomarker ◽  
Cell Division Cycle

scholarly journals Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10824
Author(s):  
Chen Yang ◽  
shufang Xie ◽  
Yi Wu ◽  
Guoqing Ru ◽  
Xianglei He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Dna Replication ◽  
Chemical Carcinogenesis ◽  
Cell Division Cycle ◽  
Functional Enrichment ◽  
Functional Annotations ◽  
Normal Tissues ◽  
Prognostic Implications ◽  
Tissue Specimens

Background The overall prognosis of hepatocellular carcinoma (HCC) is poor and novel prognostic biomarkers might better monitor the progression of HCC. Cell division cycle protein 45 (CDC45) plays a key role in DNA replication and considered to be involved in tumorigenesis. This study investigated CDC45 expression in tumour tissues and defined its prognostic value in HCC patients. Methods We used immunohistochemistry (IHC) staining to examine the expression of CDC45 in tumour tissue specimens and compare them with adjacent normal tissue specimens using a constructed tissue microarray (TMA) and analyzed how clinical features are related to HCC prognosis. Functional enrichment analyses were used to describe significantly involved hallmark pathways of differentially expressed genes (DEGs, which were screened out according to the high or low expression of CDC45 in tumour tissues). Results Our findings showed that the proteome expression of CDC45 was evidently downregulated in HCC tissues compared with matched normal tissues (P < 0.0001). Although we did not find any differences in terms of vascular invasion, metastasis, lymphatic infiltration, or Edmondson grade between patients with high and low CDC45 expression, low CDC45 expression was significantly correlated with microvascular invasion (P = 0.046). Multivariate analysis indicated that CDC45 expression (P = 0.035) was an independent prognostic factor for the overall survival (OS) rate of HCC patients. Patients with CDC45 expression was positively correlated with OS rates among HCC patients (P < 0.05). Functional annotations indicated that CDC45 is involved in the most significant pathways, including the cell cycle, DNA replication, chemical carcinogenesis and drug metabolism–cytochrome P450 pathways. Discussion Our findings showed that low proteomic level of CDC45 was associated with a poor prognosis in HCC patients, indicating that CDC45 might be a novel prognostic marker.

scholarly journals Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes

2017 ◽  
Vol 7 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Keiko Takagi ◽  
Tadatoshi Takayama ◽  
Yutaka Midorikawa ◽  
Hiromasa Hasegawa ◽  
Takanaga Ochiai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Cell Division ◽  
Hepatitis C ◽  
Cell Division Cycle

scholarly journals The roles of the cell division cycle-associated gene family in hepatocellular carcinoma

2021 ◽  
Vol 12 (2) ◽  
pp. 781-794
Author(s):  
Qiang Tao ◽  
Siliang Chen ◽  
Jia Liu ◽  
Peng Zhao ◽  
Lingmin Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Gene Family ◽  
Cell Division Cycle

Identification ofPFTAIREprotein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells

Hepatology ◽  
2007 ◽  
Vol 46 (2) ◽  
pp. 436-445 ◽  
Author(s):  
Etonia Y-T. Pang ◽  
Alfa H-C. Bai ◽  
Ka-Fai To ◽  
Shirley M-H. Sy ◽  
Navy L-Y. Wong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Cell Division Cycle ◽  
Carcinoma Cells ◽  
Related Gene ◽  
Hepatocellular Carcinoma Cells

scholarly journals The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular Carcinoma

2020 ◽  
Vol 11 (19) ◽  
pp. 5727-5737
Author(s):  
Bowen Wu ◽  
Yu Huang ◽  
Yingwan Luo ◽  
An Ma ◽  
Zhaoxing Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Gene Family ◽  
Prognostic Value ◽  
Cell Division Cycle ◽  
Diagnostic And Prognostic Value

scholarly journals Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Shan-Shan Jiang ◽  
Sheng-Jie Ke ◽  
Zun-Li Ke ◽  
Juan Li ◽  
Xiang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Poor Prognosis ◽  
Immune Cell ◽  
Expression Profiles ◽  
Drinking Behavior ◽  
Cell Division Cycle ◽  
Prognostic Biomarkers ◽  
Normal Tissues ◽  
Online Databases

With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most of the LIHC patients missed the best treatment period because of the untimely diagnosis. For others, even if they are temporarily cured, they have to face a very low prognostic survival rate and a very high risk of recurrence. Based on the characteristics of abnormal proliferation and uncontrolled growth of tumor cells. Cell Division Cycle Associated (CDCA) family genes, which are responsible for regulating the cell cycle and proliferation, were selected as our research object to explore the mechanism of hepatocarcinogenesis. To this end, we investigated the expression profiles of CDCA family genes in LIHC and corresponding normal tissues, and the effect of CDCAs expression on the survival of prognosis and immune cell infiltration through bioinformatics analysis methods and the publicly accessible online databases. In addition, we also analyzed the expression correlation of CDCAs and screened the neighboring genes related to functional CDCAs. The results revealed that the expression levels of CDCA1/3/5/8 were significantly increased in LIHC, regardless of stage, sex, race, drinking behavior, and other clinical factors. CDCAs expression was significantly correlated with poor prognosis and was positively correlated with the infiltration of dendritic cells, B cells, and macrophages. We also found that the most relevant neighboring genes to CDCAs in LIHC were SGO2, NDC80, BIRC5, INCENP, and PLOD1. In general, our work suggests that CDCA1/3/5/8 has the potential to be a diagnostic gene in hepatocarcinogenesis and prognostic biomarkers for LIHC patients.

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