scholarly journals Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

Aging ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 10633-10641
Author(s):  
Yakun Liu ◽  
Yan-Long Guo ◽  
Shan Meng ◽  
Hua Gao ◽  
Li-Juan Sui ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Gut Microbiota ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Higher Dietary Intake of Resveratrol Was Associated with Lower Risk of Hip Fracture- a 1:1 Matched Case-control Study in Chinese Elderly (OR18-07-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Zhaomin Liu ◽  
Yu-ming Chen
Keyword(s):  
Hip Fracture ◽  
Dietary Intake ◽  
Fracture Risk ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Elderly ◽  
Matched Case ◽  
Cis And Trans ◽  
Matched Case Control Study ◽  
Control Study

Abstract Objectives In vitro and animal experiments suggest that resveratrol (RVS) could improve bone health by alleviation of bone mineral and strength loss. However, there has been no epidemiologic evidence linking habitual resveratrol consumption with fracture risk. The aim of the study was to testify the association of habitual RSV consumption with hip fracture risk in Chinese elderly. Methods This was a 1:1 age- and gender- matched case–control study among Chinese elderly. Eligible cases were newly diagnosed (within 2-week). Dietary survey was conducted by a 79-item validated food frequency questionnaire. The habitual intake of RSV was estimated as the sum of trans-and cis-resveratrol and trans- and cis-piceid based on the available database of Phenol Explorer. Multivariate conditional logistic regression was applied to examine the relationship of dietary RSV and RSV rich foods with the risk of hip fracture. Results A total of 1070 pairs of hip fracture incident cases and controls were included in the analysis, with an average age of 70.6 y and body mass index (BMI) of 22.5 kg/m2. The controls were recruited from both community (82.3%) and hospital (17.7%). The average total RSV intake was 178.6 μg/d and 96.6% participants had no habitual red wine consumption. After adjustment of a range of potential confounders, comparing with the lowest quartile, the highest quartile group had a reduced hip fracture risk by 80.2% (OR: 0.198, 0.099∼0.394) for total RSV, and 46.7% (OR: 0.533, 0.319∼0.890) for grapes intake in a significant dose-response manner across the quartiles (all P for trend < 0.001). Similar findings were observed for cis- and trans-RSV, as well as cis- and trans-Piceid. Sensitivity analysis with exclusion of patients with chronic disorders made little change in the results. Subgroup analyses indicated that the findings were consistent across gender (men and women), BMI (below or above median), physical activities (below or above median), supplementation of calcium (yes or no), as well as habitual tea drinking (yes or no). Conclusions Our findings indicated that higher dietary RSV was associated with a reduced risk of hip fracture in Chinese elderly. As dietary intake of RSV is modifiable, this finding would be of public health importance with respect to fracture prevention in elderly. Funding Sources This work was jointly supported by the National Natural Science Foundation of China (Grants 81773416, 30872100 and 81072299).

scholarly journals No distinction in the gut microbiota between diarrhea predominant-irritable bowel syndrome and healthy subjects: matched case–control study in Thailand

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sawangpong Jandee ◽  
Suppana Chuensakul ◽  
Suppasil Maneerat
Keyword(s):  
Clinical Trial ◽  
Gut Microbiota ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Fecal Microbiota ◽  
Case Control ◽  
Matched Case ◽  
Irritable Bowel ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background Alteration in the gut microbiota has been proposed in irritable bowel syndrome (IBS) pathogenesis, especially in the diarrheal type (IBS-D). We conducted this study to evaluate the fecal microbiota in Thai IBS-D patients when compared with healthy subjects as well as to evaluate the effects of probiotics on changes in the gut microbiota correlated with symptoms. Methods A matched case–control study was conducted on diagnosed IBS-D patients, based on the Rome IV criteria and healthy controls. Stool samples were collected in preservation tubes. Bacterial deoxyribonucleic acid extraction was performed and amplified. Next, 16S ribosomal ribonucleic acid genes sequencing was performed to identify the microbiome in both the groups. IBS-D patients were provided with a probiotic mixture that was rich in Lactobacillus acidophillus and Bifidobacterium bifidum over 8 weeks. Changes in the symptoms, stool characteristics, and fecal microbiota were evaluated and compared with the corresponding baseline values. Results Twenty IBS-D patients with 20 age and gender-matched controls were included in this study. The baseline characteristics were not significantly different between the groups, including the mode of birth and the history of breastfeeding in infancy. No significant difference was noted in the fecal microbiota between the IBS-D patients and controls. The IBS symptom severity scales (IBS-SSS) were not statistically different after probiotic prescription; although, the bowel movements, the sense of urgency to go to the toilet and passing of mucous stool had obviously decreased. No change was noted in the fecal microbiota after receiving the experimental probiotic, except for an increase in the proportion of B. bifidum. Conclusion Alteration in the gut microbiota composition was probably not the main pathogenic mechanism in the Thai IBS-D patients assessed in this study. However, modifying microbiomes with potentially protective bacteria seems to be a beneficial therapy. Thai Clinical trial registry: TCTR20191211006, Date of registration: 10 Dec 2019. Retrospectively registered, Clinical trial URL: www.clinicaltrials.in.th

A matched case–control study of circumstances of occupational same-level falls and risk of wrist, ankle and hip fracture in women over 45 years of age

Ergonomics ◽  
2008 ◽  
Vol 51 (12) ◽  
pp. 1960-1972 ◽  
Author(s):  
Santosh K. Verma ◽  
David A. Lombardi ◽  
Wen-Ruey Chang ◽  
Theodore K. Courtney ◽  
Melanye J. Brennan
Keyword(s):  
Hip Fracture ◽  
Case Control Study ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study

2018 ◽  
Vol 62 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Ryo Inoue ◽  
Saori Kashiwagi ◽  
Kazuhiko Uchiyama ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Higher dietary carotenoid intake associated with lower risk of hip fracture in middle-aged and elderly Chinese: A matched case-control study

Bone ◽  
2018 ◽  
Vol 111 ◽  
pp. 116-122 ◽  
Author(s):  
Wen-ting Cao ◽  
Fang-fang Zeng ◽  
Bao-lin Li ◽  
Jie-sheng Lin ◽  
Ya-yong Liang ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Lower Risk ◽  
Case Control Study ◽  
Case Control ◽  
Middle Aged ◽  
Elderly Chinese ◽  
Matched Case ◽  
Dietary Carotenoid ◽  
Matched Case Control Study ◽  
Control Study
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