scholarly journals Nuclear protein export pathway in aging therapeutics

Aging ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 4682-4684
Author(s):  
Bulmaro Cisneros ◽  
Ian García-Aguirre
Keyword(s):  
Nuclear Protein ◽  
Protein Export ◽  
Export Pathway

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

Science ◽  
1997 ◽  
Vol 278 (5335) ◽  
pp. 141-144 ◽  
Author(s):  
Batool Ossareh-Nazari ◽  
Françoise Bachelerie ◽  
Catherine Dargemont
Keyword(s):  
Nuclear Protein ◽  
Protein Export

scholarly journals A PIP Gets the Plasmodium Protein Export Pathway Going

2012 ◽  
Vol 11 (2) ◽  
pp. 99-100
Author(s):  
Rays H.Y. Jiang ◽  
Matthias Marti
Keyword(s):  
Protein Export ◽  
Export Pathway

scholarly journals Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

Aging Cell ◽  
2019 ◽  
Vol 18 (5) ◽  
Author(s):  
Ian García‐Aguirre ◽  
Alma Alamillo‐Iniesta ◽  
Ruth Rodríguez‐Pérez ◽  
Griselda Vélez‐Aguilera ◽  
Elianeth Amaro‐Encarnación ◽  
...  
Keyword(s):  
Nuclear Protein ◽  
Protein Export ◽  
Premature Aging

scholarly journals Reconstitution of nuclear protein export in isolated nuclear envelopes

2002 ◽  
Vol 158 (5) ◽  
pp. 849-854 ◽  
Author(s):  
Jan Peter Siebrasse ◽  
Elias Coutavas ◽  
Reiner Peters
Keyword(s):  
Protein Kinase ◽  
Nuclear Export ◽  
Xenopus Oocytes ◽  
Nuclear Protein ◽  
Nuclear Export Signal ◽  
Protein Export ◽  
Leptomycin B ◽  
Permeabilized Cells ◽  
Export Signal ◽  
Kinase A

Signal-dependent nuclear protein export was studied in perforated nuclei and isolated nuclear envelopes of Xenopus oocytes by optical single transporter recording. Manually isolated and purified oocyte nuclei were attached to isoporous filters and made permeable for macromolecules by perforation. Export of a recombinant protein (GG-NES) containing the nuclear export signal (NES) of the protein kinase A inhibitor through nuclear envelope patches spanning filter pores could be induced by the addition of GTP alone. Export continued against a concentration gradient, and was NES dependent and inhibited by leptomycin B and GTPγS, a nonhydrolyzable GTP analogue. Addition of recombinant RanBP3, a potential cofactor of CRM1-dependent export, did not promote GG-NES export at stoichiometric concentration but gradually inhibited export at higher concentrations. In isolated filter-attached nuclear envelopes, export of GG-NES was virtually abolished in the presence of GTP alone. However, a preformed export complex consisting of GG-NES, recombinant human CRM1, and RanGTP was rapidly exported. Unexpectedly, export was strongly reduced when the export complex contained RanGTPγS or RanG19V/Q69L-GTP, a GTPase-deficient Ran mutant. This paper shows that nuclear transport, previously studied in intact and permeabilized cells only, can be quantitatively analyzed in perforated nuclei and isolated nuclear envelopes.

scholarly journals The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export

2012 ◽  
Vol 125 (1) ◽  
pp. 144-154 ◽  
Author(s):  
I. Waldmann ◽  
C. Spillner ◽  
R. H. Kehlenbach
Keyword(s):  
Nuclear Protein ◽  
Protein Export

scholarly journals An Essential Nuclear Protein in Trypanosomes Is a Component of mRNA Transcription/Export Pathway

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20730 ◽  
Author(s):  
Mariana Serpeloni ◽  
Carolina Borsoi Moraes ◽  
João Renato Carvalho Muniz ◽  
Maria Cristina Machado Motta ◽  
Augusto Savio Peixoto Ramos ◽  
...  
Keyword(s):  
Nuclear Protein ◽  
Mrna Transcription ◽  
Export Pathway

scholarly journals Suppressor Analysis Reveals a Role for SecY in the SecA2-Dependent Protein Export Pathway of Mycobacteria

2013 ◽  
Vol 195 (19) ◽  
pp. 4456-4465 ◽  
Author(s):  
L. S. Ligon ◽  
N. W. Rigel ◽  
A. Romanchuk ◽  
C. D. Jones ◽  
M. Braunstein
Keyword(s):  
Protein Export ◽  
Export Pathway ◽  
Dependent Protein ◽  
Suppressor Analysis
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