scholarly journals Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study

Aging ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 4592-4602 ◽  
Author(s):  
Dmitry Kats ◽  
Kelly R. Evenson ◽  
Donglin Zeng ◽  
Christy L. Avery ◽  
Priya Palta ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Late Life ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Physical Activity Volume ◽  
Aric Study

scholarly journals Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study

2018 ◽  
Vol 15 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Priya Palta ◽  
A. Richey Sharrett ◽  
Jennifer A. Deal ◽  
Kelly R. Evenson ◽  
Kelley Pettee Gabriel ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study

Metabolites ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 59
Author(s):  
Jun Xu ◽  
Guning Liu ◽  
Sheila M. Hegde ◽  
Priya Palta ◽  
Eric Boerwinkle ◽  
...  
Keyword(s):  
Physical Activity ◽  
Lower Risk ◽  
Leisure Time Physical Activity ◽  
Premature Death ◽  
Disease Etiology ◽  
Atherosclerosis Risk In Communities ◽  
Risk Of Death ◽  
Atherosclerosis Risk ◽  
Metabolic Equivalent Of Task ◽  
Aric Study

Habitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study using chromatography–mass spectrometry. We regressed self-reported moderate-to-vigorous intensity leisure-time physical activity (LTPA) against each metabolite, adjusting for traditional risk factors. A standardized metabolite risk score (MRS) was constructed to examine its association with all-cause mortality using the Cox proportional hazard model. We identified 10 metabolites associated with LTPA (p < 2.04 × 10−4) and established that an increase of one unit of the metabolic equivalent of task-hours per week (MET·hr·wk−1) in LTPA was associated with a 0.012 SD increase in MRS. During a median of 27.5 years of follow-up, we observed 1928 deaths. One SD increase of MRS was associated with a 10% lower risk of death (HR = 0.90, 95% CI: 0.85–0.95). The highest vs. the lowest MRS quintile rank was associated with a 22% reduced risk of death (HR = 0.78, 95% CI: 0.62–0.94). The effects were consistent across race and sex groups. In summary, we identified a set of metabolites associated with LTPA and an MRS associated with a lower risk of death. Our study provides novel insights into the potential mechanisms underlying the health impacts of physical activity.

Abstract P377: Changes in Leisure-time Physical Activity and Risk of Ischemic and Hemorrhagic Stroke: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Logan Cowan ◽  
Yelena Tarasenko ◽  
Priya Palta ◽  
Kelly R Evenson ◽  
Kamakshi Lakshminarayan
Keyword(s):  
Physical Activity ◽  
Ischemic Stroke ◽  
Leisure Time ◽  
Hemorrhagic Stroke ◽  
Stroke Risk ◽  
Leisure Time Physical Activity ◽  
Cox Proportional Hazards ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Ischemic Stroke Risk

Introduction: Engagement in leisure-time physical activity (PA) levels recommended by the American Heart Association (AHA) is inversely associated with both ischemic and hemorrhagic stroke risk. PA levels fluctuate over the lifecourse, but the association between changes in PA from mid- to late-life and stroke risk is unknown. Hypothesis: Participants who maintained ideal levels of PA or increased their PA across 6 years will have lower ischemic and hemorrhagic stroke risk relative to those who had persistently poor PA. Methods: We included 11,658 participants of the Atherosclerosis Risk in Communities study without a history of CHD or stroke at visit 3 (1993-1995). Leisure-time PA was assessed using the modified Baecke questionnaire at visits 1 and 3 and categorized according to the AHA guidelines for PA (ideal, intermediate, or poor). All adjudicated definite and probable incident ischemic and hemorrhagic strokes between visit 3 and end of year 2013 were included. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for ischemic and hemorrhagic stroke by categories of PA at visits 1 and 3. Those with poor PA at both visits were the referent group. We adjusted for age, sex, race/center, smoking, alcohol consumption, hypertension, diabetes mellitus, LDL, HDL, triglycerides, and body mass index. Results: During a median of 18.7 years of follow-up, 640 incident ischemic strokes and 76 hemorrhagic strokes occurred. In adjusted analyses, participants with ideal PA at both visits had a significantly lower ischemic stroke risk (HR=0.75 (0.59, 0.96)) but not significantly lower hemorrhagic stroke risk (HR=1.27 (0.65, 2.48)). Those whose PA levels increased from poor to ideal also had lower ischemic stroke risk (HR=0.74 (0.54, 1.03)) but not hemorrhagic stroke risk (HR=0.74 (0.28, 2.02)). Conclusion: Increasing PA between visit 1 and visit 3 was associated with lower ischemic stroke risk. Increasing PA may be an important component of stroke prevention.

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