scholarly journals Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

Aging ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 359-369 ◽  
Author(s):  
Danielle Hiam ◽  
Cassandra Smith ◽  
Sarah Voisin ◽  
Josh Denham ◽  
Xu Yan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Telomere Length ◽  
Aerobic Capacity ◽  
Human Skeletal Muscle

The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity

2011 ◽  
Vol 111 (2) ◽  
pp. 427-434 ◽  
Author(s):  
Lorenzo K. Love ◽  
Paul J. LeBlanc ◽  
J. Greig Inglis ◽  
Nicolette S. Bradley ◽  
Jon Choptiany ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Content ◽  
Endurance Training ◽  
Aerobic Capacity ◽  
Pyruvate Dehydrogenase ◽  
Human Skeletal Muscle ◽  
Citrate Synthase ◽  
Tricarboxylic Acid Cycle ◽  
Carbohydrate Oxidation ◽  
Pyruvate Dehydrogenase Phosphatase

Pyruvate dehydrogenase (PDH) is a mitochondrial enzyme responsible for regulating the conversion of pyruvate to acetyl-CoA for use in the tricarboxylic acid cycle. PDH is regulated through phosphorylation and inactivation by PDH kinase (PDK) and dephosphorylation and activation by PDH phosphatase (PDP). The effect of endurance training on PDK in humans has been investigated; however, to date no study has examined the effect of endurance training on PDP in humans. Therefore, the purpose of this study was to examine differences in PDP activity and PDP1 protein content in human skeletal muscle across a range of muscle aerobic capacities. This association is important as higher PDP activity and protein content will allow for increased activation of PDH, and carbohydrate oxidation. The main findings of this study were that 1) PDP activity ( r2 = 0.399, P = 0.001) and PDP1 protein expression ( r2 = 0.153, P = 0.039) were positively correlated with citrate synthase (CS) activity as a marker for muscle aerobic capacity; 2) E1α ( r2 = 0.310, P = 0.002) and PDK2 protein ( r2 = 0.229, P =0.012) are positively correlated with muscle CS activity; and 3) although it is the most abundant isoform, PDP1 protein content only explained ∼18% of the variance in PDP activity ( r2 = 0.184, P = 0.033). In addition, PDP1 in combination with E1α explained ∼38% of the variance in PDP activity ( r2 = 0.383, P = 0.005), suggesting that there may be alternative regulatory mechanisms of this enzyme other than protein content. These data suggest that with higher muscle aerobic capacity (CS activity) there is a greater capacity for carbohydrate oxidation (E1α), in concert with higher potential for PDH activation (PDP activity).

scholarly journals Telomere length and regulatory proteins in human skeletal muscle with and without ongoing regenerative cycles

2012 ◽  
Vol 97 (6) ◽  
pp. 774-784 ◽  
Author(s):  
Elodie Ponsot ◽  
Andoni Echaniz-Laguna ◽  
Anna-Maria Delis ◽  
Fawzi Kadi
Keyword(s):  
Skeletal Muscle ◽  
Telomere Length ◽  
Human Skeletal Muscle ◽  
Regulatory Proteins

scholarly journals Training induced improvements in aerobic capacity can occur independent of PGC‐1[alpha] in aging human skeletal muscle

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Adam Konopka ◽  
Paul Reidy ◽  
Bozena Jemiolo ◽  
Leonard Kaminsky ◽  
Todd Trappe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Aerobic Capacity ◽  
Human Skeletal Muscle

Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy

1997 ◽  
Vol 8 (12) ◽  
pp. 1429-1438 ◽  
Author(s):  
S. Decary ◽  
V. Mouly ◽  
C. Ben Hamida ◽  
A. Sautet ◽  
J. P. Barbet ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gene Therapy ◽  
Telomere Length ◽  
Satellite Cell ◽  
Human Skeletal Muscle

The Effects of Regular Strength Training on Telomere Length in Human Skeletal Muscle

2008 ◽  
Vol 40 (1) ◽  
pp. 82-87 ◽  
Author(s):  
FAWZI KADI ◽  
ELODIE PONSOT ◽  
KARIN PIEHL-AULIN ◽  
ABIGAIL MACKEY ◽  
MICHAEL KJAER ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Strength Training ◽  
Telomere Length ◽  
Human Skeletal Muscle

What can metabolic myopathies teach us about exercise physiology?

2006 ◽  
Vol 31 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Mark A Tarnopolsky
Keyword(s):  
Skeletal Muscle ◽  
Aerobic Capacity ◽  
Human Skeletal Muscle ◽  
Exercise Physiology ◽  
Maximal Aerobic Capacity ◽  
Nutritional Interventions ◽  
Mcardle's Disease ◽  
Metabolic Myopathies ◽  
Myoadenylate Deaminase ◽  
Mcardle’S Disease

Exercise physiologists are interested in metabolic myopathies because they demonstrate how knocking out a component of a specific biochemical pathway can alter cellular metabolism. McArdle's disease (myophosphorylase deficiency) has often been studied in exercise physiology to demonstrate the influence of removing the major anaerobic energy supply to skeletal muscle. Studies of patients with McArdle's disease have shown the increased reliance on blood-borne fuels, the importance of glycogen to maximal aerobic capacity, and the use of nutritional strategies to bypass metabolic defects. Myoadenylate deaminase deficiency is the most common metabolic enzyme deficiency in human skeletal muscle. It is usually compensated for endogenously and does not have a major influence on high-energy power output. Nutritional interventions such as carbohydrate loading and carbohydrate supplementation during exercise are essential components of therapy for patients with fatty acid oxidation defects. Cases of mitochondrial myopathies illustrate the importance of peripheral oxygen extraction for maximal aerobic capacity and show how both exercise and nutritional interventions can partially compensate for these mutations. In summary, metabolic myopathies provide important insights into regulatory and nutritional aspects of the major biochemical pathways of intermediary metabolism in human skeletal muscle. Key words: myoadenylate deaminase deficiency, MELAS syndrome, McArdle's disease, mitochondrial disease, inborn errors of metabolism.

TGFß regulates metabolism of human skeletal muscle cells by miRNAs

2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

IRAK-1/IRS-1 Signaling Cross Talk in Human Skeletal Muscle—Role in Insulin Resistance

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 159-OR
Author(s):  
THEODORE P. CIARALDI ◽  
SUNDER MUDALIAR ◽  
LIWU LI ◽  
ROSARIO SCALIA ◽  
XIAO JIAN SUN ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Cross Talk ◽  
Human Skeletal Muscle
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