scholarly journals Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma

Aging ◽  
2019 ◽  
Vol 11 (22) ◽  
pp. 10183-10202 ◽  
Author(s):  
Chuanjie Zhang ◽  
Hongchao He ◽  
Xin Hu ◽  
Ao Liu ◽  
Da Huang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Single Cell ◽  
Renal Cell ◽  
Clear Cell ◽  
Rna Seq ◽  
Prognostic Signature ◽  
Cell Renal Cell Carcinoma ◽  
Development And Validation

Diagnostic Utility of RNA-Seq for Evaluation of PD-L1 Expression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Author(s):  
Maria Sorokina ◽  
Danil Stupichev ◽  
Yang Lyu ◽  
Akshaya Ramachandran ◽  
Natalia Miheecheva ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Diagnostic Utility ◽  
Rna Seq ◽  
Cell Renal Cell Carcinoma

scholarly journals Single-cell genetic analysis validates cytopathological identification of circulating cancer cells in patients with clear cell renal cell carcinoma

Oncotarget ◽  
2018 ◽  
Vol 9 (28) ◽  
pp. 20058-20074 ◽  
Author(s):  
Lucile Broncy ◽  
Basma Ben Njima ◽  
Arnaud Méjean ◽  
Christophe Béroud ◽  
Khaled Ben Romdhane ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Genetic Analysis ◽  
Cell Carcinoma ◽  
Single Cell ◽  
Cancer Cells ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Circulating Cancer Cells

scholarly journals N6-Methyladenosine-Related Long Non-coding RNA Signature Associated With Prognosis and Immunotherapeutic Efficacy of Clear-Cell Renal Cell Carcinoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Tianming Ma ◽  
Xiaonan Wang ◽  
Jiawen Wang ◽  
Xiaodong Liu ◽  
Shicong Lai ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Renal Cell ◽  
Cox Regression ◽  
Clear Cell ◽  
Gene Set Enrichment Analysis ◽  
Prognostic Signature ◽  
Cell Renal Cell Carcinoma ◽  
Cox Regression Analysis

Increasing evidence suggests that N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) play important roles in cancer progression and immunotherapeutic efficacy in clear-cell renal cell carcinoma (ccRCC). In this study, we conducted a comprehensive ccRCC RNA-seq analysis using The Cancer Genome Atlas data to establish an m6A-related lncRNA prognostic signature (m6A-RLPS) for ccRCC. Forty-four prognostic m6A-related lncRNAs (m6A-RLs) were screened using Pearson correlation analysis (|R| > 0.7, p < 0.001) and univariable Cox regression analysis (p < 0.01). Using consensus clustering, the patients were divided into two clusters with different overall survival (OS) rates and immune status according to the differential expression of the lncRNAs. Gene set enrichment analysis corroborated that the clusters were enriched in immune-related activities. Twelve prognostic m6A-RLs were selected and used to construct the m6A-RLPS through least absolute shrinkage and selection operator Cox regression. We validated the differential expression of the 12 lncRNAs between tumor and non-cancerous samples, and the expression levels of four m6A-RLs were further validated using Gene Expression Omnibus data and Lnc2Cancer 3.0 database. The m6A-RLPS was verified to be an independent and robust predictor of ccRCC prognosis using univariable and multivariable Cox regression analyses. A nomogram based on age, tumor grade, clinical stage, and m6A-RLPS was generated and showed high accuracy and reliability at predicting the OS of patients with ccRCC. The prognostic signature was found to be strongly correlated to tumor-infiltrating immune cells and immune checkpoint expression. In conclusion, we established a novel m6A-RLPS with a favorable prognostic value for patients with ccRCC. The 12 m6A-RLs included in the signature may provide new insights into the tumorigenesis and allow the prediction of the treatment response of ccRCC.

scholarly journals Identification and validation of a hypoxia-related prognostic signature in clear cell renal cell carcinoma patients

Medicine ◽  
2021 ◽  
Vol 100 (39) ◽  
pp. e27374
Author(s):  
Zhengtian Li ◽  
Gang Du ◽  
Rong Zhao ◽  
Wenkang Yang ◽  
Chan Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Signature ◽  
Cell Renal Cell Carcinoma
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