scholarly journals Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16

Aging ◽  
2019 ◽  
Vol 11 (20) ◽  
pp. 9090-9110 ◽  
Author(s):  
Guohua Zhang ◽  
Ying Xu ◽  
Chen Zou ◽  
Yinbing Tang ◽  
Jiawei Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cell Cycle Progression ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cycle Progression ◽  
Gastric Cancer Cell Proliferation

scholarly journals miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Lan Feng ◽  
Kai Cheng ◽  
Rongjia Zang ◽  
Qingdong Wang ◽  
Jianjie Wang
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cell Cycle Progression ◽  
Ectopic Expression ◽  
Pyruvate Dehydrogenase Kinase ◽  
Disease Stage ◽  
Cancer Cell Proliferation ◽  
Cycle Progression ◽  
Over Expression ◽  
Gastric Cancer Cell Proliferation

Abstract MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3.

Sign in / Sign up

Export Citation Format

Share Document