scholarly journals KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

Aging ◽  
2019 ◽  
Vol 11 (18) ◽  
pp. 7847-7858 ◽  
Author(s):  
Fang Ji ◽  
Ye Liu ◽  
Jun-Gui Hao ◽  
Li-Ping Wang ◽  
Ming-Jia Dai ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gene Polymorphism ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Han Chinese ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Study of Family Clustering and PNPLA3 Gene Polymorphism in Pediatric Non Alcoholic Fatty Liver Disease

2018 ◽  
Vol 55 (7) ◽  
pp. 561-567 ◽  
Author(s):  
Vikrant Sood ◽  
Rajeev Khanna ◽  
Dinesh Rawat ◽  
Shvetank Sharma ◽  
Seema Alam ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gene Polymorphism ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87523 ◽  
Author(s):  
Salvatore Petta ◽  
Luca Miele ◽  
Elisabetta Bugianesi ◽  
Calogero Cammà ◽  
Chiara Rosso ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Gene Polymorphism ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Protein Gene ◽  
Regulatory Protein ◽  
Alcoholic Fatty Liver ◽  
Glucokinase Regulatory Protein ◽  
Alcoholic Fatty Liver Disease

scholarly journals Sirtuin3 rs28365927 functional mutation confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

2021 ◽  
Author(s):  
Li-Jie Chen ◽  
Jing Guo ◽  
Song-xia Zhang ◽  
Ying Xu ◽  
Qing Zhao ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Han Chinese ◽  
Alcoholic Fatty Liver ◽  
Genetic Traits ◽  
Han Chinese Population ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition associated with aging, insulin resistance, metabolic syndrome, genetic factors and more. Although genetic traits are among the most important risks factors for NAFLD, the understanding of their influence is still quite limited. The present study aimed at identifying novel SNPs that may confer a risk for NAFLD in the Han Chinese population. Methods Based on the "two-hit hypothesis", candidate SNPs, including Sirtuin3 rs28365927, were genotyped by MassARRAY in B-type ultrasonography-proven NAFLD patients (n = 292) and healthy controls (n = 387). Results In a model analysis of individuals matched based on gender and age that compared 223 NAFLD and 223 non-NAFLD patients, the rs28365927 GA + AA genotype was a significant risk factor for the development of NAFLD in a dominant model. Rs28365927 was significantly associated with a higher NAFLD risk in both an additive model (A vs G) and genotypic model (GA vs GG). Among the NAFLD patients, serum levels of total bilirubin (TBIL), DBIL direct bilirubin (DBIL) and glutamic-pyruvic transaminase (ALT) in rs28365927 A allele carriers (GA + AA) were 11.1%, 14.7% and 41.5% higher, respectively, than in non-carriers (GG). Furthermore, among the NAFLD patients, the carriers of Rs28365927 allele A were positively correlated with higher ALT levels. Conclusion Sirtuin3 rs28365927 is an independent risk factor for NAFLD in the Han Chinese population.

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