scholarly journals Identification of 9 key genes and small molecule drugs in clear cell renal cell carcinoma

Aging ◽  
2019 ◽  
Vol 11 (16) ◽  
pp. 6029-6052 ◽  
Author(s):  
Yongwen Luo ◽  
Dexin Shen ◽  
Liang Chen ◽  
Gang Wang ◽  
Xuefeng Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Molecule ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Small Molecule Drugs ◽  
Key Genes

Identification of potential key genes and key pathways related to clear cell renal cell carcinoma through bioinformatics analysis

2020 ◽  
Vol 52 (8) ◽  
pp. 853-863
Author(s):  
Wenxin Zhai ◽  
Haijiao Lu ◽  
Shenghua Dong ◽  
Jing Fang ◽  
Zhuang Yu
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Bioinformatics Analysis ◽  
Clear Cell ◽  
Interaction Network ◽  
Polymerase Chain Reaction Analysis ◽  
Cell Renal Cell Carcinoma ◽  
Key Genes

Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignancy of the genitourinary system and is associated with high mortality rates. However, the molecular mechanism of ccRCC pathogenesis is still unclear, which translates to few effective diagnostic and prognostic biomarkers. In this study, we conducted a bioinformatics analysis on three Gene Expression Omnibus datasets and identified 437 differentially expressed genes (DEGs) related to ccRCC development and prognosis, of which 311 and 126 genes are respectively down-regulated and up-regulated. The protein–protein interaction network of these DEGs consists of 395 nodes and 1872 interactions and 2 prominent modules. The Staphylococcus aureus infection and complement and coagulation cascades are significantly enriched in module 1 and are likely involved in ccRCC progression. Forty-two hub genes were screened, of which von Willebrand factor, TIMP metallopeptidase inhibitor 1, plasminogen, formimidoyltransferase cyclodeaminase, solute carrier family 34 member 1, hydroxyacid oxidase 2, alanine-glyoxylate aminotransferase 2, phosphoenolpyruvate carboxykinase 1, and 3-hydroxy-3-methylglutaryl-CoA synthase 2 are possibly related to the prognosis of ccRCC. The differential expression of all nine genes was confirmed by quantitative real-time polymerase chain reaction analysis of the ccRCC and normal renal tissues. These key genes are potential biomarkers for the diagnosis and prognosis of ccRCC and warrant further investigation.

scholarly journals Identification of key genes involved in the metastasis of clear cell renal cell carcinoma

2019 ◽  
Author(s):  
Wenhao Wei ◽  
Yufeng Lv ◽  
Zuhuan Gan ◽  
Yanxian Zhang ◽  
Xueqiong Han ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Key Genes

scholarly journals Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis

2018 ◽  
Vol 14 (3) ◽  
pp. 266-279 ◽  
Author(s):  
Lushun Yuan ◽  
Guang Zeng ◽  
Liang Chen ◽  
Gang Wang ◽  
Xiaolong Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Expression Analysis ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Key Genes
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