scholarly journals miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN

Aging ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 5744-5756 ◽  
Author(s):  
Ming He ◽  
Peng Shen ◽  
Chuang Qiu ◽  
Jiashi Wang
Keyword(s):  
Cell Proliferation ◽  
Osteosarcoma Cell ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

scholarly journals Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis

Aging ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 4141-4151 ◽  
Author(s):  
He Ming ◽  
Qiu Chuang ◽  
Wang Jiashi ◽  
Li Bin ◽  
Wang Guangbin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Osteosarcoma Cell ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

scholarly journals MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression

Aging ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 1294-1305 ◽  
Author(s):  
Wang Jiashi ◽  
Qiu Chuang ◽  
Zhang Zhenjun ◽  
Wang Guangbin ◽  
Li Bin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Osteosarcoma Cell ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

microRNA-30e-5p Up-Regulation Subdues Osteosarcoma Cell Proliferation and Metastasis via Regulating Collagen Triple Helix Repeat Containing 1

2021 ◽  
Vol 11 (9) ◽  
pp. 1683-1690
Author(s):  
Yong Duan ◽  
Jin Hai Tan ◽  
Sheng Xiang Tao ◽  
SiYi Liu ◽  
Qian Jin Zheng
Keyword(s):  
Cell Proliferation ◽  
Distant Metastasis ◽  
Poor Prognosis ◽  
Triple Helix ◽  
Osteosarcoma Cell ◽  
Clinical Indicators ◽  
Qrt Pcr ◽  
Collagen Triple Helix ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

The cancerous and matched para-carcinoma tissues were gained from total of 40 patients with OS, miR-30e-5p level was monitored through qRT-PCR, and the relevance between abnormal expressed miR-30e-5p and clinical indicators was uncovered. Simultaneously, miR-30e-5p expressive level in common-applied OS cells was detected by qRT-PCR. Additionally, miR-30e-5p suppression and overexpression models were constructed, and CCK-8 and transwell procedures were subsequently executed to analyze the influences of miR-30e-5p in OS cells. Further, relation between miR-30e-5p and CTHRC1 was forecased, meanwhile CTHRC1 function in miR-30e-5p-modulated OS cells was explored. Low expressed miR-30e-5p is linked to the distant metastasis and poor prognosis, which may restrain the malignant progression of OS by targeting CTHRC1.

scholarly journals Gynura procumbens ethanolic extract suppresses osteosarcoma cell proliferation and metastasis in vitro

2013 ◽  
Vol 6 (1) ◽  
pp. 113-117 ◽  
Author(s):  
HENG WANG ◽  
JI WEN ZHOU ◽  
DA HUA FU ◽  
YANG ZHOU ◽  
WEN ZHAO CHENG ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Ethanolic Extract ◽  
Osteosarcoma Cell ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

scholarly journals Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zehua Zhang ◽  
Fei Dai ◽  
Fei Luo ◽  
Wenjie Wu ◽  
Shuai Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Therapy ◽  
Disease Free Survival ◽  
Tumor Stage ◽  
Migration And Invasion ◽  
Osteosarcoma Cell ◽  
Proliferation And Metastasis ◽  
New Biomarkers

AbstractOsteosarcoma is a malignant osteoblastic tumor that can gravely endanger the lives and health of children and adolescents. Therefore, there is an urgent need to explore new biomarkers for osteosarcoma and determine new targeted therapies to improve the efficacy of osteosarcoma treatment. Diaphanous related formin 3 (DIAPH3) promotes tumorigenesis in hepatocellular carcinoma and lung adenocarcinoma, suggesting that DIAPH3 may be a target for tumor therapy. To date, there have been no reports on the function of DIAPH3 in osteosarcoma. DIAPH3 protein expression in osteosarcoma tissues and healthy bone tissues adjacent to cancer cells was examined by immunohistochemical staining. DIAPH3 mRNA expression correlates with overall survival and reduced disease-free survival. DIAPH3 protein is upregulated in osteosarcoma tissues, and its expression is significantly associated with tumor size, tumor stage, node metastasis, and distant metastasis. Functional in vitro experiments revealed that DIAPH3 knockdown suppressed cell proliferation and suppressed cell migration and invasion of osteosarcoma cell lines MG-63 and HOS. Functional experiments demonstrated that DIAPH3 knockdown inhibited subcutaneous tumor growth and lung metastasis in vivo. In conclusion, DIAPH3 expression can predict the clinical outcome of osteosarcoma. In addition, DIAPH3 is involved in the proliferation and metastasis of osteosarcoma, and as such, DIAPH3 may be a potential therapeutic target for osteosarcoma.

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