scholarly journals Additional data support the role of LINC00673 rs11655237 C>T in the development of neuroblastoma

Aging ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 2369-2377 ◽  
Author(s):  
Yong Li ◽  
Zhen-Jian Zhuo ◽  
Haiyan Zhou ◽  
Jiabin Liu ◽  
Zan Liu ◽  
...  
Keyword(s):  
Additional Data ◽  
Data Support

Covid-19 In Man: A Very Dangerous Affair.

2021 ◽  
Vol 21 ◽  
Author(s):  
Giuseppe Lisco ◽  
Vito A. Giagulli ◽  
Giovanni De Pergola ◽  
Anna De Tullio ◽  
Edoardo Guastamacchia ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Metabolic Diseases ◽  
Systemic Disease ◽  
Public Health Issue ◽  
Immune System Dysfunction ◽  
Data Support ◽  
Systemic Spread ◽  
The Impact

Background: The novel pandemic of Coronavirus disease 2019 (COVID-19) has becoming a public health issue since March 2020 considering that more than 30 million people were found to be infected worldwide. Particularly, recent evidences suggested that men may be considered as at higher risk of poor prognosis or death once the infection occurred and concerns surfaced in regard of the risk of a possible testicular injury due to SARS-CoV-2 infection. Results: Several data support the existence of a bivalent role of testosterone (T) in driving poor prognosis in patients with COVID-19. On one hand, this is attributable to the fact that T may facilitate SARS-CoV-2 entry in human cells by means of an enhanced expression of transmembrane serine-protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2). At the same time, younger man with normal testicular function compared to women of similar age are prone to develop a blunted immune response against SARS-CoV-2, being exposed to less viral clearance and more viral shedding and systemic spread of the disease. Conversely, low levels of serum T observed in hypogonadal men predispose them to a greater background systemic inflammation, cardiovascular and metabolic diseases, and immune system dysfunction, hence driving harmful consequences once SARS-CoV-2 infection occurred. Finally, SARS-CoV-2, as a systemic disease, may also affect testicles with possible concerns for current and future testicular efficiency. Preliminary data suggested that SARS-CoV-2 genome is not normally found in gonads and gametes, therefore sex transmission could be excluded as a possible way to spread the COVID-19. Conclusion: Most data support a role of T as a bivalent risk factor for poor prognosis (high/normal in younger; lower in elderly) in COVID-19. However, the impact of medical treatment aimed to modify T homeostasis for improving the prognosis of affected patients is unknown in this clinical setting. In addition, testicular damage may be a harmful consequence of the infection even in case it occurred asymptomatically but no long-term evidences are currently available to confirm and quantify this phenomenon. Different authors excluded the presence of SARS-CoV-2 in sperm and oocytes, thus limiting worries about both a potential sexual and gamete-to-embryos transmission of COVID-19. Despite these evidence, long-term and well-designed studies are needed to clarify these issues.

scholarly journals A Large-Scale COVID-19 Twitter Chatter Dataset for Open Scientific Research—An International Collaboration

Epidemiologia ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 315-324
Author(s):  
Juan M. Banda ◽  
Ramya Tekumalla ◽  
Guanyu Wang ◽  
Jingyuan Yu ◽  
Tuo Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Social Dynamics ◽  
Additional Data ◽  
Open Data ◽  
Data Sources ◽  
Research Projects ◽  
Research Groups ◽  
The World ◽  
Data Source

As the COVID-19 pandemic continues to spread worldwide, an unprecedented amount of open data is being generated for medical, genetics, and epidemiological research. The unparalleled rate at which many research groups around the world are releasing data and publications on the ongoing pandemic is allowing other scientists to learn from local experiences and data generated on the front lines of the COVID-19 pandemic. However, there is a need to integrate additional data sources that map and measure the role of social dynamics of such a unique worldwide event in biomedical, biological, and epidemiological analyses. For this purpose, we present a large-scale curated dataset of over 1.12 billion tweets, growing daily, related to COVID-19 chatter generated from 1 January 2020 to 27 June 2021 at the time of writing. This data source provides a freely available additional data source for researchers worldwide to conduct a wide and diverse number of research projects, such as epidemiological analyses, emotional and mental responses to social distancing measures, the identification of sources of misinformation, stratified measurement of sentiment towards the pandemic in near real time, among many others.

scholarly journals Statistical Speech Segmentation in Tone Languages: The Role of Lexical Tones

2017 ◽  
Vol 61 (1) ◽  
pp. 84-96 ◽  
Author(s):  
David M. Gómez ◽  
Peggy Mok ◽  
Mikhail Ordin ◽  
Jacques Mehler ◽  
Marina Nespor
Keyword(s):  
Speech Processing ◽  
Additional Data ◽  
Native Speakers ◽  
Speech Segmentation ◽  
Lexical Tones ◽  
Tone Languages ◽  
Transitional Probabilities ◽  
Lexical Processes

Research has demonstrated distinct roles for consonants and vowels in speech processing. For example, consonants have been shown to support lexical processes, such as the segmentation of speech based on transitional probabilities (TPs), more effectively than vowels. Theory and data so far, however, have considered only non-tone languages, that is to say, languages that lack contrastive lexical tones. In the present work, we provide a first investigation of the role of consonants and vowels in statistical speech segmentation by native speakers of Cantonese, as well as assessing how tones modulate the processing of vowels. Results show that Cantonese speakers are unable to use statistical cues carried by consonants for segmentation, but they can use cues carried by vowels. This difference becomes more evident when considering tone-bearing vowels. Additional data from speakers of Russian and Mandarin suggest that the ability of Cantonese speakers to segment streams with statistical cues carried by tone-bearing vowels extends to other tone languages, but is much reduced in speakers of non-tone languages.

Impact of Similarity of Interviewer-Interviewee and Interviewer-Interviewer on Ratings in a Selection Interview

1980 ◽  
Vol 47 (3_suppl) ◽  
pp. 1087-1092 ◽  
Author(s):  
Katherine F. Shepard ◽  
Maureen Hallinan
Keyword(s):  
Decision Making ◽  
Additional Data ◽  
Social Approval ◽  
Background Characteristics ◽  
Selection Interview ◽  
Ideal Candidate ◽  
Selection Interviews ◽  
Actual Selection

This study aimed to determine whether similarity of interviewer and interviewee or interviewer and interviewer influenced applicant interview ratings. Data on background characteristics, relative interests and need for social approval were secured from 21 faculty interviewers and 296 applicants during actual selection interviews. Contrary to prior findings based on simulated activity, the results did not uphold the role of similarity. Additional data gathered from follow-up interviews with faculty interviewers point to preconceived conceptions of an “ideal” candidate as a stronger reference point for decision making in selection interviews than similarity to self.

Update on factors motivating pharmacy students to pursue residency and fellowship training

2013 ◽  
Vol 70 (16) ◽  
pp. 1397-1403 ◽  
Author(s):  
Bryan C. McCarthy ◽  
Lynn M. Weber
Keyword(s):  
Additional Data ◽  
Supply And Demand ◽  
Fellowship Training ◽  
Faculty Members ◽  
Pharmacy Students ◽  
Direct Patient Care ◽  
Motivating Factors ◽  
Fellowship Program ◽  
Similar Survey

Abstract Purpose The factors motivating pharmacy students to pursue residency and fellowship training in 2011 versus 1993 were assessed. Methods A survey replicating previous research was electronically sent to 794 residency directors and 29 fellowship program directors with a request to forward the survey to current residents and fellows. A similar survey was sent to 124 colleges of pharmacy with a request to forward the survey to the faculty member most involved with residency and fellowship promotion within their doctor of pharmacy (Pharm.D.) curriculum. Participants were asked to rank leading motivating factors and barriers to pharmacy students pursuing these programs. Additional data collected included when and the methods by which these programs are promoted. Results Among residents and fellows, 865 usable surveys were returned. The leading motivating reasons for residents and fellows to pursue training were “to gain knowledge and experience,” “to gain confidence,” and “understood as a prerequisite for certain jobs.” A total of 124 U.S. pharmacy schools were surveyed, and 65 (52%) returned completed responses. “Understood as a prerequisite for certain jobs,” “faculty stressing importance,” and “recognition of the new and challenging roles for pharmacists in the future” were the factors most frequently cited by faculty members. Conclusion Compared with previous research, a new factor motivating pharmacy students to pursue residency and fellowship training is the consideration that these opportunities are a prerequisite for certain jobs. This development may be attributable to trends in the supply and demand of pharmacists, the recognition of the value in these programs by major pharmacy organizations, and the evolving role of pharmacists in direct patient care.

Biogenic approaches using citrus extracts for the synthesis of metal nanoparticles: the role of flavonoids in gold reduction and stabilization

2016 ◽  
Vol 40 (2) ◽  
pp. 1420-1429 ◽  
Author(s):  
Jelver Alexander Sierra ◽  
Caio Raphael Vanoni ◽  
Milton André Tumelero ◽  
Cristiani Campos Plá Cid ◽  
Ricardo Faccio ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Theoretical Data ◽  
Data Support ◽  
Citrus Flavonoids

Experimental and theoretical data support the easy reduction of Au3+ into self-stabilized nanoparticles by citrus flavonoids.

scholarly journals JURIDICAL ANALYSIS OF THE ROLE AND FUNCTION OF CUSTOMS TO PREVENT THE Smuggling of Goods to Realize INCREASING STATE INCOME

2021 ◽  
Vol 1 (1) ◽  
pp. 26-36
Author(s):  
Rendi Gunawan ◽  
Lia Fadjriani ◽  
Feby Milanie
Keyword(s):  
Additional Data ◽  
Type B ◽  
Legal Rules ◽  
The Public ◽  
Descriptive Research ◽  
Literature Searches ◽  
State Income ◽  
And Function ◽  
Role And Function

In the Juridical Analysis of the Role of Customs and Excise in Supervising and Preventing Crimes of Smuggling of Goods at the Customs Commission Type B Batam, it aims to discuss the legal arrangements for the role of customs in supervising and preventing criminal acts of smuggling of goods and the implementation of obstacle factors, obstacles and solutions for the role of customs in supervising and preventing the crime of smuggling of goods (research study at the Customs and Excise KPU type B Batam). This study aims to determine the Juridical Analysis of the Role of Customs and Excise in Supervising and Preventing the Crime of Smuggling of Goods at the Customs Commission Type B Batam.The research conducted is descriptive research with the method normative legal approach (normative juridical) is carried out by means of study literature. Data collection tools used in this research are data in the form of document studies and literature searches and by using additional data in the form of interviews.The results of the study indicate that the general legal arrangement of Customs and Excise authority according to Law No. 17 of 2006 is, Customs and Excise receives reports or information from someone about a criminal act, summons people to be heard and examined as suspects or witnesses, examines, seeks , and collect information on criminal acts, arrest and detain people suspected of committing criminal acts, request information and evidence from suspects who commit criminal acts.For this reason, it is hoped that with the existence of complete legal rules and firm witnesses related to the crime of smuggling of goods, all related elements are able to understand the legal rules made to protect the public from the threat of danger, and legal rules should be emphasized so that no more criminal acts of smuggling of goods occur.

scholarly journals CHARACTERISTICS OF UV ABSORBANCE BY HEXANE EXTRACTS OF APPLE SURFACES SUGGEST A MODIFIED HYPOTHESIS ON THE ROLE OF CONJUGATED TRIENES IN SCALD DEVELOPMENT ON APPLES

HortScience ◽  
1992 ◽  
Vol 27 (11) ◽  
pp. 1159d-1159
Author(s):  
Zhanyuan Du ◽  
William J. Bramlage
Keyword(s):  
Hexane Extract ◽  
Uv Absorbance ◽  
Superficial Scald ◽  
Data Support ◽  
Conjugated Trienes ◽  
Hexane Extracts ◽  
Fruit Surface

Much correlative data support the hypothesis that superficial scald on apples results from oxidation of α farnesene to conjugated trienes (CT) in the coating of apples. However, these associations are poorly defined both chemically and physiologically. α Farnesene and CT are measured as OD 232 and OD 281-290, respectively, of a hexane extract of the fruit surface. During assays, we observed anomalies in absorbance characteristics of extracts from fruit with different scald potentials, particularly in the region of 258 nm. Results suggest that absorbance near 258 nm might represent a metabolite of CT, which may be further metabolized. It appeared that under different conditions, CT metabolism could be altered, resulting in changed ratios of OD 258/OD 281. Higher ratios correlated with lower scald development, regardless of CT concentration. Thus, CT metabolism, rather than its concentration, may determine if scald occurs.

Sign in / Sign up

Export Citation Format

Share Document