scholarly journals Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells

Aging ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 2026-2051 ◽  
Author(s):  
Masaru Miyano ◽  
Rosalyn W. Sayaman ◽  
Marcus H. Stoiber ◽  
Chun-Han Lin ◽  
Martha R. Stampfer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Myoepithelial Cells ◽  
Related Gene ◽  
Age Related ◽  
Luminal Epithelial Cells

Age-related gene expression and DNA methylation changes in rhesus macaque

Genomics ◽  
2020 ◽  
Vol 112 (6) ◽  
pp. 5147-5156
Author(s):  
Min Zhou ◽  
Liang Zhang ◽  
Qiao Yang ◽  
Chaochao Yan ◽  
Peng Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Rhesus Macaque ◽  
Related Gene ◽  
Age Related

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Gene ◽  
2016 ◽  
Vol 590 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Chenghong Liao ◽  
Qian Han ◽  
Yuanye Ma ◽  
Bing Su
Keyword(s):  
Gene Expression ◽  
Visual Cortex ◽  
Rhesus Macaque ◽  
Gene Expression Change ◽  
Gabaergic System ◽  
Related Gene ◽  
Expression Change ◽  
Age Related

Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly Men

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S243
Author(s):  
Shlomit Radom-Aizik ◽  
Shlomo Hayek ◽  
Gidi Rechavi ◽  
Ninette Amariglio ◽  
Hillel Halkin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Related Gene ◽  
Elderly Men ◽  
Age Related

scholarly journals Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jialiang Yang ◽  
◽  
Tao Huang ◽  
Francesca Petralia ◽  
Quan Long ◽  
...  
Keyword(s):  
Gene Expression ◽  
Complex Disease ◽  
Principal Component ◽  
Tissue Expression ◽  
Whole Body ◽  
Disease Genes ◽  
Related Gene ◽  
Tissue Specific ◽  
Age Related ◽  
Holistic Understanding

Abstract Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed and some essential tissues (e.g., heart and lung) show much stronger “co-aging” than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

scholarly journals Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations

Nature Aging ◽  
2021 ◽  
Vol 1 (9) ◽  
pp. 838-849 ◽  
Author(s):  
Sundus F. Shalabi ◽  
Masaru Miyano ◽  
Rosalyn W. Sayaman ◽  
Jennifer C. Lopez ◽  
Tiina A. Jokela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Susceptibility ◽  
Breast Cancer Subtype ◽  
Accelerated Aging ◽  
Myoepithelial Cells ◽  
Normal Breast ◽  
Younger Women ◽  
Luminal And Myoepithelial Cells ◽  
Luminal Epithelial Cells

AbstractDuring aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of lineage fidelity is a general manifestation of epithelia that are susceptible to cancer initiation. In the present study, we show that histologically normal breast tissue from younger women who are susceptible to breast cancer, as a result of harboring a germline mutation in BRCA1, BRCA2 or PALB2 genes, exhibits hallmarks of accelerated aging. These include proportionately increased luminal epithelial cells that acquired myoepithelial markers, decreased proportions of myoepithelial cells and a basal differentiation bias or failure of differentiation of cKit+ progenitors. High-risk luminal and myoepithelial cells are transcriptionally enriched for genes of the opposite lineage, inflammatory- and cancer-related pathways. We have identified breast-aging hallmarks that reflect a convergent biology of cancer susceptibility, regardless of the specific underlying genetic or age-dependent risk or the associated breast cancer subtype.

scholarly journals Ischemia-Reperfusion Injury in a Simulated Lung Transplant Setting Differentially Regulates Transcriptomic Profiles between Human Lung Endothelial and Epithelial Cells

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2713
Author(s):  
Gaowa Saren ◽  
Aaron Wong ◽  
Yun-Bi Lu ◽  
Cristina Baciu ◽  
Wenyong Zhou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Epithelial Cells ◽  
Lung Injury ◽  
Human Lung ◽  
Ischemia Reperfusion Injury ◽  
Protein Biosynthesis ◽  
Ischemia Reperfusion ◽  
Gene Clusters ◽  
Related Gene

Current understanding of mechanisms of ischemia-reperfusion-induced lung injury during lung preservation and transplantation is mainly based on clinical observations and animal studies. Herein, we used cell and systems biology approaches to explore these mechanisms at transcriptomics levels, especially by focusing on the differences between human lung endothelial and epithelial cells, which are crucial for maintaining essential lung structure and function. Human pulmonary microvascular endothelial cells and human lung epithelial cells were cultured to confluent, subjected to different cold ischemic times (CIT) to mimic static cold storage with preservation solution, and then subjected to warm reperfusion with a serum containing culture medium to simulate lung transplantation. Cell morphology, viability, and transcriptomic profiles were studied. Ischemia-reperfusion injury induced a CIT time-dependent cell death, which was associated with dramatic changes in gene expression. Under normal control conditions, endothelial cells showed gene clusters enriched in the vascular process and inflammation, while epithelial cells showed gene clusters enriched in protein biosynthesis and metabolism. CIT 6 h alone or after reperfusion had little effect on these phenotypic characteristics. After CIT 18 h, protein-biosynthesis-related gene clusters disappeared in epithelial cells; after reperfusion, metabolism-related gene clusters in epithelial cells and multiple gene clusters in the endothelial cells also disappeared. Human pulmonary endothelial and epithelial cells have distinct phenotypic transcriptomic signatures. Severe cellular injury reduces these gene expression signatures in a cell-type-dependent manner. Therapeutics that preserve these transcriptomic signatures may represent new treatment to prevent acute lung injury during lung transplantation.

scholarly journals Genetic control of age-related gene expression and complex traits in the human brain

2017 ◽  
Author(s):  
Trevor Martin ◽  
Hunter B. Fraser
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Genetic Variants ◽  
Complex Traits ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Expression Patterns ◽  
Related Gene ◽  
Age Related

AbstractAge is the primary risk factor for many of the most common human diseases—particularly neurodegenerative diseases—yet we currently have a very limited understanding of how each individual’s genome affects the aging process. Here we introduce a method to map genetic variants associated with age-related gene expression patterns, which we call temporal expression quantitative trait loci (teQTL). We found that these loci are markedly enriched in the human brain and are associated with neurodegenerative diseases such as Alzheimer’s disease and Creutzfeldt-Jakob disease. Examining potential molecular mechanisms, we found that age-related changes in DNA methylation can explain some cis-acting teQTLs, and that trans-acting teQTLs can be mediated by microRNAs. Our results suggest that genetic variants modifying age-related patterns of gene expression, acting through both cis- and trans-acting molecular mechanisms, could play a role in the pathogenesis of diverse neurological diseases.

scholarly journals Age-related Gene Expression and Histologic Changes in Human Nasal Polyps

2019 ◽  
Vol 143 (2) ◽  
pp. AB285
Author(s):  
Seong Ho Cho ◽  
Ara Jo ◽  
Lydia A. Suh ◽  
Roderick G. Carter ◽  
David B. Conley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nasal Polyps ◽  
Related Gene ◽  
Age Related ◽  
Histologic Changes
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