scholarly journals Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults

Aging ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 1096-1129 ◽  
Author(s):  
Antigoni Z. Lalia ◽  
Surendra Dasari ◽  
Matthew M. Robinson ◽  
Hinnah Abid ◽  
Dawn M. Morse ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Mitochondrial Bioenergetics ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Skeletal Muscle Protein ◽  
Muscle Protein Metabolism

scholarly journals Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia

2011 ◽  
Vol 301 (5) ◽  
pp. R1408-R1417 ◽  
Author(s):  
E. Lichar Dillon ◽  
Shanon L. Casperson ◽  
William J. Durham ◽  
Kathleen M. Randolph ◽  
Randall J. Urban ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Older Individuals ◽  
Skeletal Muscle Protein ◽  
Age Related ◽  
Muscle Protein Metabolism

The combination of increasing blood flow and amino acid (AA) availability provides an anabolic stimulus to the skeletal muscle of healthy young adults by optimizing both AA delivery and utilization. However, aging is associated with a blunted response to anabolic stimuli and may involve impairments in endothelial function. We investigated whether age-related differences exist in the muscle protein anabolic response to AAs between younger (30 ± 2 yr) and older (67 ± 2 yr) adults when macrovascular and microvascular leg blood flow were similarly increased with the nitric oxide (NO) donor, sodium nitroprusside (SNP). Regardless of age, SNP+AA induced similar increases above baseline ( P ≤ 0.05) in macrovascular flow (4.3 vs. 4.4 ml·min−1·100 ml leg−1 measured using indocyanine green dye dilution), microvascular flow (1.4 vs. 0.8 video intensity/s measured using contrast-enhanced ultrasound), phenylalanine net balance (59 vs. 68 nmol·min−1·100 ml·leg−1), fractional synthetic rate (0.02 vs. 0.02%/h), and model-derived muscle protein synthesis (62 vs. 49 nmol·min−1·100 ml·leg−1) in both younger vs. older individuals, respectively. Provision of AAs during NO-induced local skeletal muscle hyperemia stimulates skeletal muscle protein metabolism in older adults to a similar extent as in younger adults. Our results suggest that the aging vasculature is responsive to exogenous NO and that there is no age-related difference per se in AA-induced anabolism under such hyperemic conditions.

scholarly journals Delta-6-desaturase (FADS2) inhibition and omega-3 fatty acids in skeletal muscle protein turnover

2019 ◽  
Vol 18 ◽  
pp. 100622
Author(s):  
Katie M. Brown ◽  
Sunita Sharma ◽  
Ella Baker ◽  
William Hawkins ◽  
Marie van der Merwe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Protein Turnover ◽  
Muscle Protein ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Skeletal Muscle Protein ◽  
Muscle Protein Turnover ◽  
Delta 6 Desaturase

scholarly journals Insulin action on skeletal muscle protein metabolism during catabolic states

1999 ◽  
Vol 39 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Jean Grizard ◽  
Dominique Dardevet ◽  
Michèle Balage ◽  
Daniel Larbaud ◽  
Sandrine Sinaud ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Metabolism ◽  
Insulin Action ◽  
Muscle Protein ◽  
Skeletal Muscle Protein ◽  
Muscle Protein Metabolism

Resistance Training and Skeletal Muscle Protein Metabolism in Eumenorrheic Females: Implications for Researchers and Practitioners

2019 ◽  
Vol 49 (11) ◽  
pp. 1637-1650 ◽  
Author(s):  
Olivia E. Knowles ◽  
Brad Aisbett ◽  
Luana C. Main ◽  
Eric J. Drinkwater ◽  
Liliana Orellana ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Skeletal Muscle Protein ◽  
Muscle Protein Metabolism

Effect of Protein-Carbohydrate Intake During Exercise on Skeletal Muscle Protein Metabolism in Elderly Individuals

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S323
Author(s):  
Masao Mizuno ◽  
Tokuko Mizuno ◽  
Keitaro Matsumoto ◽  
Bo Dilling-Hansen ◽  
Axel Lahoz ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Carbohydrate Intake ◽  
Skeletal Muscle Protein ◽  
Elderly Individuals ◽  
Muscle Protein Metabolism
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