scholarly journals Computerized cognitive training and brain derived neurotrophic factor during bed rest: mechanisms to protect individual during acute stress

Aging ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 393-407 ◽  
Author(s):  
Angelina Passaro ◽  
Cecilia Soavi ◽  
Uros Marusic ◽  
Enrico Rejc ◽  
Juana M. Sanz ◽  
...  
Keyword(s):  
Cognitive Training ◽  
Neurotrophic Factor ◽  
Acute Stress ◽  
Bed Rest ◽  
Brain Derived Neurotrophic Factor ◽  
Computerized Cognitive Training

Effect of Cognitive Training on the Expression of Brain-Derived Neurotrophic Factor in Lymphocytes of Mild Cognitive Impairment Patients

2014 ◽  
Vol 17 (2) ◽  
pp. 235-238 ◽  
Author(s):  
Tiziana Casoli ◽  
Cinzia Giuli ◽  
Marta Balietti ◽  
Belinda Giorgetti ◽  
Moreno Solazzi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Training ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jonna Nilsson ◽  
Örjan Ekblom ◽  
Maria Ekblom ◽  
Alexander Lebedev ◽  
Olga Tarassova ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Exercise ◽  
Cognitive Training ◽  
Neurotrophic Factor ◽  
Controlled Trial ◽  
Empirical Support ◽  
Brain Derived Neurotrophic Factor ◽  
Lifestyle Interventions ◽  
Training Outcome ◽  
Subsequent Learning

AbstractMultidomain lifestyle interventions represents a promising strategy to counteract cognitive decline in older age. Brain-derived neurotrophic factor (BDNF) is essential for experience-dependent plasticity and increases following physical exercise, suggesting that physical exercise may facilitate subsequent learning. In a randomized-controlled trial, healthy older adults (65–75 years) completed a 12-week behavioral intervention that involved either physical exercise immediately before cognitive training (n = 25; 13 females), physical exercise immediately after cognitive training (n = 24; 11 females), physical exercise only (n = 27; 15 females), or cognitive training only (n = 21; 12 females). We hypothesized that cognition would benefit more from cognitive training when preceded as opposed to followed by physical exercise and that the relationship between exercise-induced increases in peripheral BDNF and cognitive training outcome would be greater when cognitive training is preceded by physical exercise. Greater increases of plasma BDNF were associated with greater cognitive training gains on trained task paradigms, but only when such increases preceded cognitive training (ß = 0.14, 95% CI [0.04, 0.25]). Average cognitive training outcome did not differ depending on intervention order (ß = 0.05, 95% CI [−0.10, 0.20]). The study provides the first empirical support for a time-critical but advantageous role for post-exercise increases in peripheral BDNF for learning at an interindividual level in older adults, with implications for future multidomain lifestyle interventions.

scholarly journals Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats

2015 ◽  
Vol 308 (6) ◽  
pp. H612-H622 ◽  
Author(s):  
Benedek Erdos ◽  
Iara Backes ◽  
Michael L. McCowan ◽  
Linda F. Hayward ◽  
Deborah A. Scheuer
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Stress Responses ◽  
Neurotrophic Factor ◽  
Fluorescent Protein ◽  
Acute Stress ◽  
Cardiovascular Responses ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Expression ◽  
Intracerebroventricular Infusion

Brain-derived neurotrophic factor (BDNF) expression increases in the paraventricular nucleus of the hypothalamus (PVN) in response to hypertensive stimuli including stress and hyperosmolarity. However, it is unclear whether BDNF in the PVN contributes to increases in blood pressure (BP). We tested the hypothesis that increased BDNF levels within the PVN would elevate baseline BP and heart rate (HR) and cardiovascular stress responses by altering central angiotensin signaling. BP was recorded using radiotelemetry in male Sprague-Dawley rats after bilateral PVN injections of adeno-associated viral vectors expressing green fluorescent protein (GFP) or myc epitope-tagged BDNF fusion protein. Cardiovascular responses to acute stress were evaluated 3 to 4 wk after injections. Additional GFP and BDNF-treated animals were equipped with osmotic pumps for intracerebroventricular infusion of saline or the angiotensin type-1 receptor (AT1R) inhibitor losartan (15 μg·0.5 μl−1·h−1). BDNF treatment significantly increased baseline BP (121 ± 3 mmHg vs. 99 ± 2 mmHg in GFP), HR (394 ± 9 beats/min vs. 314 ± 4 beats/min in GFP), and sympathetic tone indicated by HR- and BP-variability analysis and adrenomedullary tyrosine hydroxylase protein expression. In contrast, body weight and BP elevations to acute stressors decreased. BDNF upregulated AT1R mRNA by ∼80% and downregulated Mas receptor mRNA by ∼50% in the PVN, and losartan infusion partially inhibited weight loss and increases in BP and HR in BDNF-treated animals without any effect in GFP rats. Our results demonstrate that BDNF overexpression in the PVN results in sympathoexcitation, BP and HR elevations, and weight loss that are mediated, at least in part, by modulating angiotensin signaling in the PVN.

scholarly journals Serum levels of brain-derived neurotrophic factor in acute and posttraumatic stress disorder: a case report study

2009 ◽  
Vol 31 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Simone Hauck ◽  
Fabiano Gomes ◽  
Érico de Moura Silveira Júnior ◽  
Ellen Almeida ◽  
Marianne Possa ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Acute Stress ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Acute Stress Disorder ◽  
Global Assessment Of Functioning ◽  
Before And After

OBJECTIVE: The aim of this study was to evaluate brain-derived neurotrophic factor levels in two patients, one with posttraumatic stress disorder and one with acute stress disorder, before and after treatment, and to compare those levels to those of healthy controls. METHOD: Brain-derived neurotrophic factor level, Davidson Trauma Scale, Beck Depression Inventory, Global Assessment of Functioning, and Clinical Global Impression were assessed before and after 6 weeks of treatment. RESULTS: Brain-derived neurotrophic factor levels were higher in patients than in matched controls before treatment. After 6 weeks, there was a reduction in symptoms and an improvement in functioning in both cases. At the same time, brain-derived neurotrophic factor levels decreased after treatment, even in case 2, treated with psychotherapy only. CONCLUSIONS: These results suggest that serum levels of brain-derived neurotrophic factor, as opposed to what has been described in mood disorders, are increased in posttraumatic stress disorder as well as in acute stress disorder.

scholarly journals Acute exercise-induced increases in brain-derived neurotrophic factor in plasma relates to subsequent learning in older adults: A randomized controlled intervention trial

2019 ◽  
Author(s):  
Jonna Nilsson ◽  
Örjan Ekblom ◽  
Maria Ekblom ◽  
Benjamin Garzon ◽  
Alexander V. Lebedev ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Exercise ◽  
Cognitive Training ◽  
Neurotrophic Factor ◽  
Acute Exercise ◽  
Training Session ◽  
Empirical Support ◽  
Brain Derived Neurotrophic Factor ◽  
Subsequent Learning ◽  
Exercise Induced

Multidomain lifestyle interventions have been identified as a promising strategy to counteract cognitive decline in older age but mechanistic accounts for how such interventions should be designed are lacking. Brain-derived neurotrophic factor is essential for experience-dependent plasticity and increases transiently following physical exercise, suggesting that physical exercise may facilitate subsequent learning by inducing a heightened state of brain plasticity. We therefore hypothesized that cognitive ability in older adults would benefit more from cognitive training when it is immediately preceded as opposed to followed by physical exercise and that the relationship between exercise-induced increases in peripheral BDNF (assessed at pretest) and cognitive training outcomes (change from pretest to posttest) would be greater when cognitive training is preceded by physical exercise. Healthy older adults (n=97) were randomized to receive either physical exercise immediately before cognitive training, physical exercise immediately after cognitive training, physical exercise only, or cognitive training only, in each training session during a 12-week long intervention period. Consistent with the hypothesis, greater increases of plasma BDNF following physical exercise were associated with greater cognitive training gains on trained task paradigms, but only when such increases immediately preceded cognitive training (ß=0.14, 95% CI [0.04, 0.25]). However, average cognitive training outcome did not significantly differ depending on whether participants received physical exercise before or after cognitive training (ß=0.05, 95% CI [-0.10, 0.20]). The study provides the first empirical support for a time-critical but advantageous role for post-exercise increases in peripheral BDNF for learning in older adults at an interindividual level, with implications for the design of future multidomain interventions. More research will be required to understand the factors that likely interact with and counteract such beneficial effects and to determine whether all older adults could potentially benefit from engaging in physical exercise prior to learning.

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