scholarly journals Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function

Aging ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 2414-2424 ◽  
Author(s):  
Leland Perice ◽  
Nir Barzilai ◽  
Joe Verghese ◽  
Erica F. Weiss ◽  
Roee Holtzer ◽  
...  
Keyword(s):  
Growth Factor ◽  
Muscle Mass ◽  
Insulin Like Growth Factor ◽  
Exceptional Longevity ◽  
Factor I ◽  
Growth Factor I ◽  
And Function

INSULIN-LIKE GROWTH FACTOR-I IMPROVES MUCOSAL STRUCTURE AND FUNCTION IN TRANSPLANTED RAT SMALL INTESTINE

1995 ◽  
Vol 59 (5) ◽  
pp. 755-761 ◽  
Author(s):  
Wei Zhang ◽  
Wendy L. Frankel ◽  
William T. Adamson ◽  
Jonathan A. Roth ◽  
Mark P. Mantell ◽  
...  
Keyword(s):  
Small Intestine ◽  
Growth Factor ◽  
Structure And Function ◽  
Insulin Like Growth Factor ◽  
Rat Small Intestine ◽  
Factor I ◽  
Growth Factor I ◽  
And Function

Characterization, regulation, and function of specific cell membrane receptors for insulin-like growth factor I on bone endothelial cells

2009 ◽  
Vol 9 (3) ◽  
pp. 329-337 ◽  
Author(s):  
Gianna Fiorelli ◽  
Claudio Orlando ◽  
Susanna Benvenuti ◽  
Francesco Franceschelli ◽  
Sandro Bianchi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Cell Membrane ◽  
Membrane Receptors ◽  
Specific Cell ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
And Function

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle

2006 ◽  
Vol 100 (6) ◽  
pp. 1778-1784 ◽  
Author(s):  
Elisabeth R. Barton
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Mass ◽  
Muscle Hypertrophy ◽  
Muscle Development ◽  
Muscle Size ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Insulin-like growth factor I (IGF-I) is a critical protein for skeletal muscle development and regeneration. Its ability to promote skeletal muscle hypertrophy has been demonstrated by several methods. Alternative splicing of the Igf-1 gene does not affect the mature IGF-I protein but does produce different E peptide extensions, which have been reported to modify the potency of IGF-I. Viral-mediated delivery of murine IGF-IA and IGF-IB into skeletal muscle of 2-wk-old and 6-mo-old mice was utilized to compare the effects of the isoforms on muscle mass. In young mice, tissue content of IGF-I protein was significantly higher in rAAV-treated muscles than control muscles at 1, 2, and 4 mo postinjection. Viral injection of IGF-IB produced two- to sevenfold more IGF-I than rAAVIGF-IA. Hypertrophy was observed 2 and 4 mo postinjection, where both rAAVIGF-IA and rAAVIGF-IB were equally effective in increasing muscle mass. These results suggest that there is a threshold of IGF-I production necessary to promote muscle hypertrophy in young growing animals regardless of isoform. In 6-mo-old animals, only rAAVIGF-IA produced significant increases in muscle size, even though increased IGF-I content was observed after injection of both isoforms. Therefore, the ability for IGF-IB to promote muscle hypertrophy is only effective in growing animals, suggesting that the bioavailability of this isoform or its receptor affinity diminishes with age.

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