scholarly journals Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

Aging ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 500-512 ◽  
Author(s):  
Edward O. List ◽  
Darlene E. Berryman ◽  
Yuji Ikeno ◽  
Gene B. Hubbard ◽  
Kevin Funk ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Health Benefits ◽  
Male Mice

scholarly journals 17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner

2020 ◽  
Author(s):  
Silvana Sidhom ◽  
Augusto Schneider ◽  
Yimin Fang ◽  
Samuel McFadden ◽  
Justin Darcy ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Growth Hormone Receptor ◽  
Health Benefits ◽  
Male Mice ◽  
Wild Type ◽  
Somatotropic Axis ◽  
Gh Secretion ◽  
17Β Estradiol ◽  
Estradiol 17Β

Abstract Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was recently found to elicit health benefits, including improved insulin sensitivity and extend longevity exclusively in male mice. Given that 17β-E2 is known to modulate somatotropic signaling in females through actions in the pituitary and liver, we hypothesized that 17α-E2 may be modulating the somatotropic axis in males, thereby contributing to health benefits. Herein, we demonstrate that 17α-E2 increases hepatic insulin-like growth factor 1 (IGF1) production in male mice without inducing any changes in pulsatile growth hormone (GH) secretion. Using growth hormone receptor knockout (GHRKO) mice, we subsequently determined that the induction of hepatic IGF1 by 17α-E2 is dependent upon GH signaling in male mice, and that 17α-E2 elicits no effects on IGF1 production in female mice. We also determined that 17α-E2 failed to feminize the hepatic transcriptional profile in normal (N) male mice, as evidenced by a clear divergence between the sexes, regardless of treatment. Conversely, significant overlap in transcriptional profiles was observed between sexes in GHRKO mice, and this was unaffected by 17α-E2 treatment. Based on these findings, we propose that 17α-E2 acts as a pleiotropic pathway modulator in male mice by uncoupling IGF1 production from insulin sensitivity. In summary, 17α-E2 treatment upregulates IGF1 production in wild-type (and N) male mice in what appears to be a GH-dependent fashion, while no effects in female IGF1 production are observed following 17α-E2 treatment.

Growth hormone receptor in dopaminergic neurones regulates stress‐induced prolactin release in male mice

2021 ◽  
Vol 33 (3) ◽  
Author(s):  
Frederick Wasinski ◽  
Fernanda M. Chaves ◽  
João A. B. Pedroso ◽  
Naira S. Mansano ◽  
João Paulo Camporez ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Male Mice ◽  
Prolactin Release

Laron syndrome – A case Report

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 104-106
Author(s):  
Javaid Ahmad Bhat ◽  
Moomin Hussain Bhat ◽  
Hilal Bhat ◽  
Mona Sood ◽  
Shariq Rashid Masoodi
Keyword(s):  
Growth Hormone ◽  
Case Report ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Genetic Disorder ◽  
Female Child ◽  
Receptor Signaling ◽  
Laron Syndrome ◽  
Rare Genetic Disorder ◽  
Igf I

Background : Laron & colleagues (1966) reported a rare genetic disorder in Israliei Jewish sublings which was characterized by insensitivity to growth hormone due to abnormality in growth hormone receptor or post receptor signaling pathway.Case Report: We hereby report a case of a 5 year old female child who presented to us with features similar to Laron syndrome. The diagnosis was made & confirmed by various Lab. investigations like low IGF-I levels and managed accordingly. JMS 2017; 20 (2):104-106  

Three novel Growth Hormone Receptor (GHR) splicing mutations causing a spectrum of Growth Hormone Insensitivity

2019 ◽  
Author(s):  
Emily Cottrell ◽  
Avinaash Maharaj ◽  
Tasneem Ladha ◽  
Sumana Chatterjee ◽  
Anna Grandone ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Splicing Mutations ◽  
Growth Hormone Insensitivity

Isolation of two types of cDNA encoding growth hormone receptor-like genes in the Japanese eel, Anguilla japonica

2002 ◽  
Vol 68 (sup1) ◽  
pp. 959-960 ◽  
Author(s):  
YUICHI OZAKI ◽  
HARUHISA FUKADA ◽  
YUKINORI KAZETO ◽  
SHINJI ADACHI ◽  
AKIHIKO HARA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Anguilla Japonica ◽  
Japanese Eel
Sign in / Sign up

Export Citation Format

Share Document