scholarly journals Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

Aging ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. 731-741 ◽  
Author(s):  
Bruna Corominas-Faja ◽  
Elvira Santangelo ◽  
Elisabet Cuyàs ◽  
Vicente Micol ◽  
Jorge Joven ◽  
...  
Keyword(s):  
Biological Activity ◽  
Olive Oil ◽  
Anti Cancer ◽  
Computer Aided

scholarly journals The Occurrence and Biological Activity of Tormentic Acid—A Review

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3797
Author(s):  
Marta Olech ◽  
Wojciech Ziemichód ◽  
Natalia Nowacka-Jechalke
Keyword(s):  
Biological Activity ◽  
Plant Species ◽  
Current Knowledge ◽  
In Vivo Studies ◽  
Natural Sources ◽  
Anti Cancer ◽  
Biochemical Mechanisms ◽  
Tormentic Acid

This review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyperlipidemic, hepatoprotective, cardioprotective, neuroprotective, anti-cancer, anti-osteoarthritic, antinociceptive, antioxidative, anti-melanogenic, cytotoxic, antimicrobial, and antiparasitic) confirmed in in vitro and in vivo studies is compiled and described. Biochemical mechanisms affected by TA are indicated. Moreover, issues related to the biotechnological methods of production, effective eluents, and TA derivatives are presented.

scholarly journals Potential anti-cancer effects of virgin olive oil phenolson colorectal carcinogenesis modelsin vitro

2005 ◽  
Vol 117 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Chris I.R. Gill ◽  
Adele Boyd ◽  
Emily McDermott ◽  
Mark McCann ◽  
Maurizio Servili ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Colorectal Carcinogenesis ◽  
Anti Cancer

Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents

2019 ◽  
Vol 27 (14) ◽  
pp. 3070-3081 ◽  
Author(s):  
Guifang Han ◽  
Lihua Qing ◽  
Meng Wu ◽  
Yuxiang Wang ◽  
Yuxiu Liu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Design Synthesis ◽  
Activity Evaluation ◽  
Anti Cancer

Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies

2016 ◽  
Vol 7 (10) ◽  
pp. 4145-4159 ◽  
Author(s):  
R. Fabiani
Keyword(s):  
Systematic Review ◽  
Olive Oil ◽  
In Vivo Studies ◽  
Anti Cancer ◽  
Secoiridoid Derivatives ◽  
Phenolic Alcohols

Olive oil phenolic alcohols and their secoiridoid derivatives may prevent cancer.

The chain length of biologically produced ( R )-3-hydroxyalkanoic acid affects biological activity and structure of anti-cancer peptides

2015 ◽  
Vol 204 ◽  
pp. 7-12 ◽  
Author(s):  
Emilia Szwej ◽  
Marc Devocelle ◽  
Shane Kenny ◽  
Maciej Guzik ◽  
Stephen O’Connor ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chain Length ◽  
Anti Cancer ◽  
Hydroxyalkanoic Acid

Optimization of the synthesis and pharmacological characterization of substances on the basis of computer aided prognosis of biological activity spectra

1996 ◽  
Vol 30 (9) ◽  
pp. 570-573 ◽  
Author(s):  
V. V. Poroikov ◽  
D. A. Filimonov ◽  
A. V. Stepanchikova ◽  
A. P. Budunova ◽  
E. V. Shilova ◽  
...  
Keyword(s):  
Biological Activity ◽  
Pharmacological Characterization ◽  
Computer Aided

scholarly journals STEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTS

2020 ◽  
Vol 19 (1) ◽  
pp. 22-52
Author(s):  
V. A. Zolottsev ◽  
A. S. Latysheva ◽  
V. S. Pokrovsky ◽  
I. I. Khan ◽  
R. L. M. Almanza ◽  
...  
Keyword(s):  
Biological Activity ◽  
Natural Compounds ◽  
The Past ◽  
Anti Cancer ◽  
Steroid Conjugates

The review is dedicated to results of investigations of steroid conjugates published predominantly over the past decade. It consists of three parts in which the data concerning biological activity of steroid conjugates with known drugs, steroid dimers, and steroid conjugates with some natural compounds, their fragments and related derivatives and analogs, are discussed. The structures of 231 steroid conjugates and their anti-cancer properties are presented.

scholarly journals Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

2021 ◽  
Vol 14 (8) ◽  
pp. 779
Author(s):  
Kena Zhang ◽  
Christine Tran ◽  
Mouad Alami ◽  
Abdallah Hamze ◽  
Olivier Provot
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Metal Catalysts ◽  
Point Of View ◽  
Cyclization Reactions ◽  
Metal Free ◽  
Michael Reactions ◽  
Anti Cancer ◽  
Synthetic Routes ◽  
Metal Catalyzed

This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives. In the first part, we first presented the synthetic routes that have been reported from a methodological point of view to access the pyrazinoindole unit according to cyclization reactions using or not using metal catalysts. Then, syntheses and neuropsychiatric, auto-immune, anti-infectious and anti-cancer properties of pyrazinoindoles were detailed. In the second part, we first reported the main accesses to pyrazinoindol-1-one substrates according to Michael reactions, metal-catalyzed and metal-free cyclization reactions. The syntheses and anti-cancer, anti-infectious, anti-allergenic and neuropsychiatric properties of pyrazinoindolones were next described and discussed.

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