scholarly journals Plasma microRNA biomarkers for detection of mild cognitive impairment: Biomarker Validation Study

Aging ◽  
2013 ◽  
Vol 5 (12) ◽  
pp. 925-938 ◽  
Author(s):  
Kira S. Sheinerman ◽  
Vladimir G. Tsivinsky ◽  
Laila Abdullah ◽  
Fiona Crawford ◽  
Samuil R. Umansky
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Validation Study ◽  
Biomarker Validation ◽  
Plasma Microrna

scholarly journals Plasma microRNA biomarkers for detection of mild cognitive impairment

Aging ◽  
2012 ◽  
Vol 4 (9) ◽  
pp. 590-605 ◽  
Author(s):  
Kira S. Sheinerman ◽  
Vladimir G. Tsivinsky ◽  
Fiona Crawford ◽  
Michael J. Mullan ◽  
Laila Abdullah ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Plasma Microrna

scholarly journals Word reading threshold and mild cognitive impairment: a validation study

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Genevieve Arsenault-Lapierre ◽  
Howard Bergman ◽  
Howard Chertkow
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Validation Study ◽  
Word Reading

scholarly journals Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Mitsunori Kayano ◽  
Sayuri Higaki ◽  
Jun-ichi Satoh ◽  
Kenji Matsumoto ◽  
Etsuro Matsubara ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Correlation Analysis ◽  
Biomarker Detection ◽  
Differential Correlation ◽  
Plasma Microrna

scholarly journals Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 734 ◽  
Author(s):  
Aidan Kenny ◽  
Hazel McArdle ◽  
Miguel Calero ◽  
Alberto Rabano ◽  
Stephen F. Madden ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Diagnosis ◽  
Cognitive Decline ◽  
Microfluidic Device ◽  
Cost Effective ◽  
Memory Deficits ◽  
Elevated Plasma ◽  
Microrna Detection ◽  
Plasma Microrna

The need for practical biomarkers for early diagnosis of Alzheimer’s disease (AD) remains largely unmet. Here we investigated the use of blood-based microRNAs as prognostic biomarkers for AD and their application in a novel electrochemical microfluidic device for microRNA detection. MicroRNA transcriptome was profiled in plasma from patients with mild cognitive impairment (MCI) and AD. MicroRNAs Let-7b and microRNA-206 were validated at elevated levels in MCI and AD, respectively. MicroRNA-206 displayed a strong correlation with cognitive decline and memory deficits. Longitudinal follow-ups over five years identified microRNA-206 increases preceding the onset of dementia. MicroRNA-206 was increased in unprocessed plasma of AD and MCI subjects, detected by our microfluidic device. While increased Let-7b levels in plasma may be used to identify patients with MCI, changes in plasma levels of microRNA-206 may be used to predict cognitive decline and progression towards dementia at an MCI stage. MicroRNA quantification via a microfluidic device could provide a practical cost-effective tool for the stratification of patients with MCI according to risk of developing AD.

scholarly journals Assessing fitness to drive—A validation study on patients with mild cognitive impairment

2017 ◽  
Vol 18 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Anselm B. M. Fuermaier ◽  
Dafne Piersma ◽  
Dick de Waard ◽  
Ragnhild J. Davidse ◽  
Jolieke de Groot ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Validation Study ◽  
Fitness To Drive
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