scholarly journals Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

Aging ◽  
2010 ◽  
Vol 2 (8) ◽  
pp. 504-513 ◽  
Author(s):  
Sandra Romero-Suarez ◽  
Jinhua Shen ◽  
Leticia Brotto ◽  
Todd Hall ◽  
ChengLin Mo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Calcium Homeostasis ◽  
Aging Process ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

scholarly journals Role of miRNAs in skeletal muscle aging

2018 ◽  
Vol Volume 13 ◽  
pp. 2407-2419 ◽  
Author(s):  
Yan Zheng ◽  
Jian Kong ◽  
Qun Li ◽  
Yan Wang ◽  
Jie Li
Keyword(s):  
Skeletal Muscle ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

scholarly journals Role of Age-Related Mitochondrial Dysfunction in Sarcopenia

2020 ◽  
Vol 21 (15) ◽  
pp. 5236 ◽  
Author(s):  
Evelyn Ferri ◽  
Emanuele Marzetti ◽  
Riccardo Calvani ◽  
Anna Picca ◽  
Matteo Cesari ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cellular Senescence ◽  
Significant Loss ◽  
Muscle Aging ◽  
Age Related ◽  
Mitochondrial Functions ◽  
Health Quality ◽  
Skeletal Muscle Aging ◽  
And Function

Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and power (i.e., dynapenia), muscle mass and quality of life, a phenomenon known as sarcopenia. This condition affects nearly one-third of the older population and is one of the main factors leading to negative health outcomes in geriatric patients. Notwithstanding the exact mechanisms responsible for sarcopenia are not fully understood, mitochondria have emerged as one of the central regulators of sarcopenia. In fact, there is a wide consensus on the assumption that the loss of mitochondrial integrity in myocytes is the main factor leading to muscle degeneration. Mitochondria are also key players in senescence. It has been largely proven that the modulation of mitochondrial functions can induce the death of senescent cells and that removal of senescent cells improves musculoskeletal health, quality, and function. In this review, the crosstalk among mitochondria, cellular senescence, and sarcopenia will be discussed with the aim to elucidate the role that the musculoskeletal cellular senescence may play in the onset of sarcopenia through the mediation of mitochondria.

scholarly journals The clinical impact and biological mechanisms of skeletal muscle aging

Bone ◽  
2019 ◽  
Vol 127 ◽  
pp. 26-36 ◽  
Author(s):  
Zaira Aversa ◽  
Xu Zhang ◽  
Roger A. Fielding ◽  
Ian Lanza ◽  
Nathan K. LeBrasseur
Keyword(s):  
Skeletal Muscle ◽  
Clinical Impact ◽  
Biological Mechanisms ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

scholarly journals MicroRNAs in Skeletal Muscle Aging: Current Issues and Perspectives

2018 ◽  
Vol 74 (7) ◽  
pp. 1008-1014 ◽  
Author(s):  
Hwa Jin Jung ◽  
Kwang-Pyo Lee ◽  
Ki-Sun Kwon ◽  
Yousin Suh
Keyword(s):  
Skeletal Muscle ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

scholarly journals An Evaluation Of Skeletal Muscle Aging Using A Novel Guinea Pig Model

2020 ◽  
Vol 52 (7S) ◽  
pp. 911-911
Author(s):  
Maureen A. Walsh ◽  
Robert V. Musci ◽  
Raoul F. Reiser ◽  
Kelly S. Santangelo ◽  
Karyn L. Hamilton
Keyword(s):  
Skeletal Muscle ◽  
Guinea Pig ◽  
Pig Model ◽  
Muscle Aging ◽  
Skeletal Muscle Aging ◽  
Guinea Pig Model

scholarly journals THE ROLE OF MITOCHONDRIAL ENERGETICS IN CARDIAC AND SKELETAL MUSCLE AGING

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 348-348
Author(s):  
P Rabinovitch ◽  
D J Marcinek
Keyword(s):  
Skeletal Muscle ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

Healthy skeletal muscle aging: The role of satellite cells, somatic mutations and exercise

2019 ◽  
pp. 157-200 ◽  
Author(s):  
Irene Franco ◽  
Rodrigo Fernandez-Gonzalo ◽  
Peter Vrtačnik ◽  
Tommy R. Lundberg ◽  
Maria Eriksson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cells ◽  
Somatic Mutations ◽  
Muscle Aging ◽  
Skeletal Muscle Aging
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