scholarly journals Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival

Aging ◽  
2008 ◽  
Vol 1 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Kaisa Selesniemi ◽  
Ho-Joon Lee ◽  
Teruko Niikura ◽  
Jonathan L. Tilly
Keyword(s):  
Bone Marrow ◽  
Young Adult ◽  
Reproductive Failure ◽  
Offspring Survival ◽  
Female Mice ◽  
Age Related ◽  
Donor Bone Marrow

Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice

2006 ◽  
Vol 291 (5) ◽  
pp. H2362-H2370 ◽  
Author(s):  
Scott A. Grandy ◽  
Susan E. Howlett
Keyword(s):  
Young Adult ◽  
Ventricular Myocytes ◽  
Female Mice ◽  
Ec Coupling ◽  
Age Related ◽  
Intracellular Ca ◽  
Effects Of Aging ◽  
Cardiac Excitation ◽  
Fractional Shortening ◽  
In Cells

This study characterized age-related alterations in excitation-contraction (EC)-coupling in ventricular myocytes and investigated whether these alterations are affected by the sex of the animal. Voltage-clamp experiments were conducted in myocytes from young adult (∼7 mo) and aged (∼24 mo) male and female mice. Intracellular Ca2+ concentrations and unloaded cell shortening were measured at 37°C with fura-2 and a video edge detector. Fractional shortening and Ca2+ current density were significantly reduced in aged male myocytes compared with those in young adult male cells. In addition, Ca2+ transients were significantly smaller in aged male myocytes. Sarcoplasmic reticulum (SR) content, assessed by rapid application of 10 mM caffeine, declined with age in male myocytes. However, EC coupling gain and fractional release of SR Ca2+ were similar in young adult and aged male cells. In contrast to results in male animals, fractional shortening and Ca2+ current densities were similar in young adult and aged myocytes isolated from female hearts. Furthermore, Ca2+ transient amplitudes were unaffected by age in female cells. Interestingly, SR Ca2+ content was elevated in aged female myocytes, and fractional SR Ca2+ release declined with age in females. However, the gain of EC coupling was not different in myocytes from young adult and aged female mice. These data demonstrate that age-related alterations in EC coupling are more prominent in myocytes from male hearts than in cells from female hearts and suggest that it is important to consider sex as a variable in studies of the effects of aging on cardiac EC coupling.

scholarly journals The Effects of SRT1720 Treatment on Endothelial Cells Derived from the Lung and Bone Marrow of Young and Aged, Male and Female Mice

2021 ◽  
Vol 22 (20) ◽  
pp. 11097
Author(s):  
Ushashi Chand Dadwal ◽  
Fazal Ur Rehman Bhatti ◽  
Olatundun Dupe Awosanya ◽  
Caio de Andrade Staut ◽  
Rohit U. Nagaraj ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Endothelial Cells ◽  
Bone Healing ◽  
Sirtuin 1 ◽  
Male And Female ◽  
Angiogenic Potential ◽  
Migration Rates ◽  
Female Mice ◽  
Age Related ◽  
And Function

Angiogenesis is critical for successful fracture healing. Age-related alterations in endothelial cells (ECs) may cause impaired bone healing. Therefore, examining therapeutic treatments to improve angiogenesis in aging may enhance bone healing. Sirtuin 1 (SIRT1) is highly expressed in ECs and its activation is known to counteract aging. Here, we examined the effects of SRT1720 treatment (SIRT1 activator) on the growth and function of bone marrow and lung ECs (BMECs and LECs, respectively), derived from young (3-4 month) and old (20–24 month) mice. While aging did not alter EC proliferation, treatment with SRT1720 significantly increased proliferation of all LECs. However, SRT1720 only increased proliferation of old female BMECs. Vessel-like tube assays showed similar vessel-like structures between young and old LECs and BMECs from both male and female mice. SRT1720 significantly improved vessel-like structures in all LECs. No age, sex, or treatment differences were found in migration related parameters of LECs. In males, old BMECs had greater migration rates than young BMECs, whereas in females, old BMECs had lower migration rates than young BMECs. Collectively, our data suggest that treatment with SRT1720 appears to enhance the angiogenic potential of LECs irrespective of age or sex. However, its role in BMECs is sex- and age-dependent.

scholarly journals Preconceptional Resveratrol Supplementation Partially Counteracts Age-Related Reproductive Complications in C57BL/6J Female Mice

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1934
Author(s):  
Marta Ziętek ◽  
Katarzyna Barłowska ◽  
Barbara Wijas ◽  
Ewa Szablisty ◽  
Atanas G. Atanasov ◽  
...  
Keyword(s):  
Drinking Water ◽  
Animal Models ◽  
Mating Success ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Polyphenolic Compound ◽  
Female Mice ◽  
Age Related ◽  
Increased Risk ◽  
Anti Oxidant

Aging is associated with a drastic decline in fertility/fecundity and with an increased risk of pregnancy complications. Resveratrol (RES), a natural polyphenolic compound, has shown anti-oxidant and anti-inflammatory activities in both human and animal models, thus representing a potential therapeutic and prophylactic anti-aging supplement. Here, we investigated whether preconceptional resveratrol supplementation improved reproductive outcomes in mid-aged (8-month-old) and old (12-month-old) C57BL/6J female mice. Female siblings were cohoused and assigned to either RES or vehicle supplementation to drinking water for 10 consecutive weeks. Subsequently, females were mated with non-supplemented males and their pregnancy outcomes were monitored. RES improved mating success in old, but not in mid-aged females, and prevented the occurrence of delivery complications in the latter. These results indicate that preconceptional RES supplementation could partially improve age-related reproductive complications, but it was not sufficient to restore fecundity in female mice at a very advanced age.

scholarly journals Evidence for complement-mediated bone marrow necrosis in a young adult with sickle cell disease

2021 ◽  
Vol 86 ◽  
pp. 102508
Author(s):  
Melissa Azul ◽  
Surbhi Shah ◽  
Sarah Williams ◽  
Gregory M. Vercellotti ◽  
Alexander A. Boucher
Keyword(s):  
Bone Marrow ◽  
Young Adult ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Bone Marrow Necrosis

MRI “road-map” of normal age-related bone marrow

1995 ◽  
Vol 25 (8) ◽  
pp. 596-606 ◽  
Author(s):  
A. Taccone ◽  
M. Oddone ◽  
A. Dell'Acqua ◽  
M. Occhi ◽  
M. A. Ciccone
Keyword(s):  
Bone Marrow ◽  
Road Map ◽  
Age Related ◽  
Related Bone Marrow
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