scholarly journals Estrogen receptor expression in normal breast epithelium in invasive ductal carcinoma

2020 ◽  
Author(s):  
Taşkın ERKİNÜRESİN ◽  
Hakan DEMİRCİ ◽  
Fügen VARDAR AKER
Keyword(s):  
Estrogen Receptor ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Normal Breast ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Breast Epithelium ◽  
Normal Breast Epithelium

scholarly journals Impact of estrogen receptor expression and other clinicopathologic features on tamoxifen use in ductal carcinoma in situ

Cancer ◽  
2006 ◽  
Vol 106 (10) ◽  
pp. 2113-2118 ◽  
Author(s):  
R. Barry Hird ◽  
Alfred Chang ◽  
Vincent Cimmino ◽  
Kathleen Diehl ◽  
Michael Sabel ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Clinicopathologic Features

scholarly journals Estrogen Receptor Expression in Benign Breast Epithelium and Breast Cancer Risk

1998 ◽  
Vol 90 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Seema A. Khan ◽  
Mary A. M. Rogers ◽  
Kamal K. Khurana ◽  
Michael M. Meguid ◽  
Patricia J. Numann
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Breast Epithelium

Oestrogen receptor expression in normal breast epithelium

2000 ◽  
Vol 36 ◽  
pp. 27-28 ◽  
Author(s):  
S.A Khan ◽  
M.A.M Rogers ◽  
K.K Khurana ◽  
J.F.M Siddiqui
Keyword(s):  
Oestrogen Receptor ◽  
Normal Breast ◽  
Receptor Expression ◽  
Breast Epithelium ◽  
Normal Breast Epithelium

scholarly journals Estrogen Receptor Expression Is High but Is of Lower Intensity in Tubular Carcinoma Than in Well-Differentiated Invasive Ductal Carcinoma

2014 ◽  
Vol 138 (11) ◽  
pp. 1507-1513 ◽  
Author(s):  
Julie M. Jorns ◽  
Dafydd G. Thomas ◽  
Patrick N. Healy ◽  
Stephanie Daignault ◽  
Tammi L. Vickery ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Ductal Carcinoma ◽  
Normal Breast ◽  
Receptor Expression ◽  
Luminal A ◽  
Tubular Carcinoma ◽  
Ductal Carcinomas ◽  
Well Differentiated ◽  
Er Expression

Context Tubular carcinoma (TC) is a rare, luminal A subtype of breast carcinoma with excellent prognosis, for which adjuvant chemotherapy is usually contraindicated. Objective To examine the levels of estrogen receptor (ER) and progesterone receptor expression in cases of TC and well-differentiated invasive ductal carcinoma as compared to normal breast glands and to determine if any significant differences could be detected via molecular testing. Design We examined ER and progesterone receptor via immunohistochemistry in tubular (N = 27), mixed ductal/tubular (N = 16), and well-differentiated ductal (N = 27) carcinomas with comparison to surrounding normal breast tissue. We additionally performed molecular subtyping of 10 TCs and 10 ductal carcinomas via the PAM50 assay. Results Although ER expression was high for all groups, TC had statistically significantly lower ER staining percentage (ER%) (P = .003) and difference in ER expression between tumor and accompanying normal tissue (P = .02) than well-differentiated ductal carcinomas, with mixed ductal/tubular carcinomas falling between these 2 groups. Mean ER% was 79%, 87%, and 94%, and mean tumor-normal ER% differences were 13.6%, 25.9%, and 32.6% in tubular, mixed, and ductal carcinomas, respectively. Most tumors that had molecular subtyping were luminal A (9 of 10 tubular and 8 of 10 ductal), and no significant differences in specific gene expression between the 2 groups were identified. Conclusions Tubular carcinoma exhibited decreased intensity in ER expression, closer to that of normal breast parenchyma, likely as a consequence of a high degree of differentiation. Lower ER% expression by TC may represent a potential pitfall when performing commercially available breast carcinoma prognostic assays that rely heavily on ER-related gene expression.

Estrogen receptor ? expression in normal human breast epithelium is consistent over time

2002 ◽  
Vol 102 (4) ◽  
pp. 334-337 ◽  
Author(s):  
Seema A. Khan ◽  
Kimberly A. Yee ◽  
Cassandra Kaplan ◽  
Josephine F. Siddiqui
Keyword(s):  
Estrogen Receptor ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Human Breast ◽  
Breast Epithelium ◽  
Normal Human Breast ◽  
Normal Human ◽  
Over Time
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