scholarly journals Chondroid metaplasia: a rare subtype of metaplastic breast carcinoma

2019 ◽  
Author(s):  
Semra Demirli Atıcı ◽  
Semra Salimoğlu ◽  
Yasemin Kırmızı ◽  
Dilek Kuzukıran ◽  
Cengiz Aydın
Keyword(s):  
Breast Carcinoma ◽  
Chondroid Metaplasia ◽  
Metaplastic Breast Carcinoma

scholarly journals Metaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosis

2020 ◽  
Vol 7 (4) ◽  
pp. 1277
Author(s):  
Samuel Lalhruaizela ◽  
Bhupendra Mehra
Keyword(s):  
Breast Carcinoma ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Duct Carcinoma ◽  
Increased Risk ◽  
Chondroid Metaplasia ◽  
Worse Prognosis ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma (MBC) has an incidence of <1% of all breast cancers and MBC with chondrosarcomatous differentiation is even more rare, <0.1% of all cases. The World Health Organization have classified MBC into pure epithelial-type and mixed epithelial and mesenchymal type. The epithelial-type MBC is sub-classified into squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma with spindle cell differentiation; mixed type MBC is sub-classified into carcinosarcoma and carcinoma with osseous and chondroid metaplasia. Metaplastic carcinomas of the breast are characterized by large tumour size and rapid  growth, and they are usually estrogen receptor, progesterone receptor, and HER2/neu negative and tend to have a worse prognosis than other triple negative breast cancers. There is a noteworthy increased risk of tumour recurrence and a worse prognosis with MBC compared with invasive lobular carcinoma and infiltrating duct carcinoma. We report a case of metaplastic carcinoma with extensive chondroid differentiation that is chondrosarcoma and chondroid metaplasia along with classic infiltrating duct carcinoma with involvement of ipsilateral axillary lymph nodes.

Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast

2019 ◽  
Vol 15 (3) ◽  
pp. 338-348
Author(s):  
Hale Aydin ◽  
Bahar Guner ◽  
Isil Esen Bostanci ◽  
Nazan Ciledag ◽  
Melda Boyacioglu Bulut ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Multimodality Imaging ◽  
Metaplastic Carcinoma ◽  
Imaging Features ◽  
Mri Findings ◽  
Radiologic Findings ◽  
Round Shape ◽  
Malignant Feature ◽  
Imaging Results ◽  
Metaplastic Breast Carcinoma

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

scholarly journals Diagnostic utility of snail in metaplastic breast carcinoma

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Aziza Nassar ◽  
Nicole Sookhan ◽  
Marta Santisteban ◽  
Sandra C Bryant ◽  
Judy C Boughey ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Diagnostic Utility ◽  
Metaplastic Breast Carcinoma

Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

scholarly journals Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tibor Tot ◽  
Juan José Badani De La Parra ◽  
Leif Bergkvist
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Brain Metastases ◽  
Lymph Node Metastases ◽  
Metaplastic Carcinoma ◽  
Unique Case ◽  
Carcinoma Of The Breast ◽  
Stromal Component ◽  
Node Metastases ◽  
Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

Metaplastic breast carcinoma: tumour histogenesis or dedifferentiation?

2011 ◽  
Vol 224 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Carolien HM van Deurzen ◽  
Andrew HS Lee ◽  
Muhammad S Gill ◽  
Marian BE Menke-Pluijmers ◽  
Agnes Jager ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma

scholarly journals Current Progress in the Treatment of Metaplastic Breast Carcinoma

2013 ◽  
Vol 14 (11) ◽  
pp. 6221-6225 ◽  
Author(s):  
Qing Hu ◽  
Wei-Xian Chen ◽  
Shan-Liang Zhong ◽  
Jian Li ◽  
Zhou Luo ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma
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