scholarly journals NOVEL ANTIMONY(III) HALIDE COMPLEXES WITH SOME N-ALKYL THIOUREAS: SYNTHESIS, CHARACTERIZATION AND STUDY OF THEIR EFFECT UPON THE CATALYTIC OXIDATION OF LINOLEIC ACID TO HYDROPEROXYLINOLEIC ACID BY LIPOXYGENASE

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
İbrahim İsmet ÖZTÜRK
Keyword(s):  
Linoleic Acid ◽  
Catalytic Oxidation ◽  
Halide Complexes ◽  
Hydroperoxylinoleic Acid

scholarly journals Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s

1991 ◽  
Vol 276 (2) ◽  
pp. 447-453 ◽  
Author(s):  
H Iwahashi ◽  
C E Parker ◽  
R P Mason ◽  
K B Tomer
Keyword(s):  
Liquid Chromatography ◽  
Linoleic Acid ◽  
Hyperfine Splitting ◽  
Spin Trapping ◽  
Soybean Lipoxygenase ◽  
Acid Radical ◽  
Radical Adduct ◽  
The Masses ◽  
Hydroperoxylinoleic Acid ◽  
Additional Hyperfine

Linoleic acid-derived radicals, which are formed in the reaction of linoleic acid with soybean lipoxygenase, were trapped with nitrosobenzene and the resulting radical adducts were analysed by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. Three nitrosobenzene radical adducts (peaks I, II and III) were detected; these gave the following parent ion masses: 402 for peak I, 402 for peak II, and 386 for peak III. The masses of peaks I and II correspond to the linoleic acid radicals with one more oxygen atom [L(O).]. The radicals are probably carbon-centred, because the use of 17O2 did not result in an additional hyperfine splitting. Computer simulation of the peak I radical adduct e.p.r. spectrum also suggested that the radical is carbon-centred. The peak I radical was also detected in the reaction of 13-hydroperoxylinoleic acid with FeSO4. From the above results, peak I is probably the 12,13-epoxylinoleic acid radical. An h.p.l.c.-e.p.r. experiment using [9,10,12,13-2H4]linoleic acid suggested that the 12,13-epoxylinoleic acid radical is a C-9-centred radical. Peak II is possibly an isomer of peak I. Peak III, which was observed in the reaction mixture without soybean lipoxygenase, corresponds to a linoleic acid radical (L.). The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.

Changes in the fluorescence and absorbance of lipoxygenase-1 induced by 13-lS-Hydroperoxylinoleic acid and linoleic acid

1975 ◽  
Vol 397 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Maarten R. Egmond ◽  
Alessandro Finazzi-Agrò ◽  
Paolo M. Fasella ◽  
Gerrit A. Veldink ◽  
Johannes F.G. Vliegenthart
Keyword(s):  
Linoleic Acid ◽  
Hydroperoxylinoleic Acid

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

α-Linoleic acid enhances the capacity of α1-antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils

Pneumologie ◽  
2016 ◽  
Vol 70 (07) ◽  
Author(s):  
N Aggarwal ◽  
S Wrenger ◽  
V Grau ◽  
T Welte ◽  
S Janciauskiene
Keyword(s):  
Linoleic Acid ◽  
Human Blood ◽  
Blood Neutrophils
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