scholarly journals RELATIONSHIP BETWEEN THE ALLOY FREQUENCY OF THE T102C POLYMORPHISM OF THE 5HT2A GENE WITH ANTHROPOMETRIC AND CARDIOMETABOLIC MEASURES

2019 ◽  
Vol 1 (2) ◽  
pp. 157-170
Author(s):  
BLK Mallmanna ◽  
CRA Tonini ◽  
EO Chielle ◽  
Eduardo Ottobelli Chielle
Keyword(s):  
Diastolic Pressure ◽  
Hdl Cholesterol ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Allele Distribution ◽  
Homeostatic Model Assessment ◽  
T102c Polymorphism ◽  
Relationship Of ◽  
The Relationship ◽  
Anthropometric Markers

Obesity is a disease characterized by excessive body fat. Among the neurobiological factors associated with obesity, the serotonergic system stands out. The neurotransmitter of these circuits is serotonin (5-HT). Decreased levels of 5-HT have been linked to increased desire to ingest sweets and carbohydrates. This study aims to verify the relationship of the 5HT2A T102C gene polymorphism with obesity and anthropometric parameters. Blood samples and anthropometric data were collected from 150 volunteers, divided between the control and obese groups. The results showed that for individuals with diastolic pressure (p = 0.3681), Estimated Mean Glycemia (GMe) (p = 0.0228) and Homeostatic Model Assessment (HOMA-IR-IR) (p = 0.001) all altered, a higher frequency of C alleles was observed. For normal GMe (p = 0.0270), a higher frequency of the T allele was observed. There was no difference for the allele distribution between the normal and altered groups for the parameters of Triglycerides, HDL cholesterol, total cholesterol, glycated hemoglobin and Insulin. The distribution of the alleles between the groups, normal diastolic pressure (p = 0.3681) and HOMA-IR (p = 0.9203) groups presented no difference. From the genotypic analyzes of the T102C polymorphism of the 5HT2A gene, it was possible to demonstrate a relationship between the presence of the C allele with biochemical and anthropometric markers related to obesity and hypertension.

scholarly journals The Relationship between Insulin Resistance and the Cardiovascular Biomarker Growth Differentiation Factor-15 in Obese Patients

2011 ◽  
Vol 57 (2) ◽  
pp. 309-316 ◽  
Author(s):  
Greisa Vila ◽  
Michaela Riedl ◽  
Christian Anderwald ◽  
Michael Resl ◽  
Ammon Handisurya ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Insulin Sensitivity ◽  
Oral Glucose ◽  
Model Assessment ◽  
Obese Patients ◽  
Growth Differentiation Factor 15 ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model ◽  
The Relationship

BACKGROUND Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine linked to obesity comorbidities such as cardiovascular disease, inflammation, and cancer. GDF-15 also has adipokine properties and recently emerged as a prognostic biomarker for cardiovascular events. METHODS We evaluated the relationship of plasma GDF-15 concentrations with parameters of obesity, inflammation, and glucose and lipid metabolism in a cohort of 118 morbidly obese patients [mean (SD) age 37.2 (12) years, 89 females, 29 males] and 30 age- and sex-matched healthy lean individuals. All study participants underwent a 75-g oral glucose tolerance test; 28 patients were studied before and 1 year after Roux-en-Y gastric bypass surgery. RESULTS Obese individuals displayed increased plasma GDF-15 concentrations (P < 0.001), with highest concentrations observed in patients with type 2 diabetes. GDF-15 was positively correlated with age, waist-to-height ratio, mean arterial blood pressure, triglycerides, creatinine, glucose, insulin, C-peptide, hemoglobin A1c, and homeostatic model assessment insulin resistance index and negatively correlated with oral glucose insulin sensitivity. Age, homeostatic model assessment index, oral glucose insulin sensitivity, and creatinine were independent predictors of GDF-15 concentrations. Roux-en-Y gastric bypass led to a significant reduction in weight, leptin, insulin, and insulin resistance, but further increased GDF-15 concentrations (P < 0.001). CONCLUSIONS The associations between circulating GDF-15 concentrations and age, insulin resistance, and creatinine might account for the additional cardiovascular predictive information of GDF-15 compared to traditional risk factors. Nevertheless, GDF-15 changes following bariatric surgery suggest an indirect relationship between GDF-15 and insulin resistance. The clinical utility of GDF-15 as a biomarker might be limited until the pathways directly controlling GDF-15 concentrations are better understood.

scholarly journals The Relationship of Finger Length Ratios (2D:4D) with Quantitative, Verbal Talent and Anthropometric Parameters

2018 ◽  
Vol 36 (1) ◽  
pp. 310-318 ◽  
Author(s):  
Raciha Sinem Balci ◽  
Ahmet Kürsad Acikgöz ◽  
Pinar Göker ◽  
Memduha Gülhal Bozkir
Keyword(s):  
Anthropometric Parameters ◽  
Finger Length ◽  
Relationship Of ◽  
The Relationship

How Image Congruity and Satisfaction Impact Customer Retention at Luxury Restaurants: A Moderated Mediation Framework

2018 ◽  
Vol 46 (6) ◽  
pp. 891-904 ◽  
Author(s):  
Heesup Han ◽  
Wansoo Kim ◽  
Sanghyeop Lee ◽  
Hye-Ran Kim
Keyword(s):  
Customer Satisfaction ◽  
Structural Model ◽  
Customer Retention ◽  
Measurement Model ◽  
Restaurant Industry ◽  
Model Assessment ◽  
Product Consumption ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

We investigated the impact of customers' image congruity and their satisfaction on customer retention at luxury restaurants. We examined the conspicuousness of product consumption as the moderator in the relationship of image congruity and customer satisfaction. Our assessment of the measurement model revealed acceptable levels of reliability and construct validity. Our findings from the structural model assessment indicated that both image congruity and customer satisfaction exerted an influence on customer retention that was sufficiently significant to explain the total variance in retention. In addition, results showed that customer satisfaction was prominent in determining retention, acting as a significant mediator. Conspicuousness of product consumption was a significant moderator of the relationship between image congruity and customer satisfaction. Overall, our findings offer researchers and practitioners in the luxury restaurant industry valuable information regarding customer retention.

scholarly journals Relationship between anthropometrics and handgrip strength among Nigerian school children

2017 ◽  
Vol 9 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Adebisi I. Hammed ◽  
Elvis I. Agbonlahor
Keyword(s):  
School Children ◽  
Handgrip Strength ◽  
Body Height ◽  
Middle Finger ◽  
Anthropometric Parameters ◽  
Moment Coefficient ◽  
Hand Length ◽  
Relationship Of ◽  
The Relationship ◽  
Nigerian School

Summary Study aim: Was to investigate the relationship of anthropometrics with handgrip strength (HGS) among Nigerian school children.Material and methods: A total of 200 school children participated in this study. An electronic handgrip dynamometer was used to measure handgrip strength (HGS) in kg. Body height and body weight were measured with a wall-mounted stadiometer in meters and a bathroom weighing scale in kg, respectively. Body mass index (BMI) was then calculated using the formula weight (kg)/height (m2). Also, hand span of both hands was measured from the tip of the thumb to the tip of the small finger with the hand opened as wide as possible. The distance from the distal wrist crease up to the base of the middle finger was taken for palm length and the distal wrist crease to the tip of the middle finger was considered for the measurement of hand length. However, the relationship between HGS and anthropometric parameters was analyzed using Pearson’s product moment coefficient of correlation.Results: The outcome of this study showed that hand and palm length correlated disproportionately and insignificantly (p > 0.05) with both dominant and non-dominant HGS. Also, hand span was found to be a disproportionate correlate of HGS, though such a correlation was only significant (p < 0.05) with dominant HGS. However, BMI and handedness were observed to associate proportionately and significantly (p < 0.05) with HGS.Conclusion: This study therefore concluded that the most important determinants of HGS among Nigerian school children are BMI, handedness and hand span, and thus could be considered as markers of nutritional and health status, as well as physical fitness of these individuals.

Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance

2017 ◽  
Vol 30 (4) ◽  
Author(s):  
Svetlana J. Milenković ◽  
Ljiljana B. Mirković ◽  
Miljana Z. Jovandarić ◽  
Dušan M. Milenković ◽  
Violeta V. Banković ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Intrauterine Growth ◽  
Homeostatic Model Assessment ◽  
Appropriate For Gestational Age ◽  
Homeostatic Model ◽  
Discordant Twins

AbstractBackground:Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested.Methods:We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins.Results:A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0.05). Insulin sensitivity (IS) and homeostatic model assessment (HOMA)-IR in IUGR twins were similar to appropriate-for-gestational-age cotwins and unrelated to adipokines. In IUGR twins, adiponectin and insulin associated positively. In larger concordant twins’ leptin level correlated with HOMA-IR and insulin.Conclusions:Leptin, but not adiponectin, levels correlate positively with anthropometric parameters in IUGR twins. IR in IUGR twins is unrelated to adipokines in the first few days of life.

Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score

2018 ◽  
Vol 33 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Branko Srećković ◽  
Ivan Soldatovic ◽  
Emina Colak ◽  
Igor Mrdovic ◽  
Mirjana Sumarac-Dumanovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Risk Score ◽  
Continuous Measure ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Apo B ◽  
Significant Difference ◽  
Homeostatic Model Assessment

Abstract Background: Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative stress causes endothelial dysfunction, hypertension and atherosclerosis. The objective of the study was to examine the correlation of homocysteine with siMS score and siMS risk score and with other MS co-founding factors. Methods: The study included 69 obese individuals (age over 30, body mass index [BMI] >25 kg/m2), classified into two groups: I-with MS (33 patients); II-without MS (36 patients). Measurements included: anthropometric parameters, lipids, glucose regulation parameters and inflammation parameters. IR was determined by homeostatic model assessment for insulin resistance (HOMA-IR). ATP III classification was applied for diagnosing MS. SiMS score was used as continuous measure of metabolic syndrome. Results: A significant difference between groups was found for C-reactive protein (CRP) (p<0.01) apolipoprotein (Apo) B, HOMA-IR and acidum uricum (p<0.05). siMS risk score showed a positive correlation with homocysteine (p=0.023), while siMS score correlated positively with fibrinogen (p=0.013), CRP and acidum uricum (p=0.000) and homocysteine (p=0.08). Homocysteine correlated positively with ApoB (p=0.036), HbA1c (p=0.047), HOMA-IR (p=0.008) and negatively with ApoE (p=0.042). Conclusions: Correlation of siMS score with homocysteine, fibrinogen, CRP and acidum uricum indicates that they are co-founding factors of MS. siMS risk score correlation with homocysteine indicates that hyperhomocysteinemia increases with age. Hyperhomocysteinemia is linked with genetic factors and family nutritional scheme, increasing the risk for atherosclerosis.

The relationship of anthropometric characteristics and motor abilities of adolescents

2020 ◽  
pp. 144-153
Author(s):  
Nikita A. Kolesnichenko ◽  
Igor M. Demets ◽  
Sergey N. Simonov
Keyword(s):  
Body Length ◽  
Significant Relationship ◽  
School Students ◽  
Anthropometric Parameters ◽  
Sports Clubs ◽  
Motor Abilities ◽  
Anthropometric Characteristics ◽  
Relationship Of ◽  
The Relationship ◽  
Sports Selection

The relationship between anthropometric parameters and the level of development of motor abilities of school students is a scientifically important and practically important topic. Using knowledge of physical development indicators it is possible to predict the success of the development of motor skills. These data can be used in the sports selection and building an effective system of physical education in secondary school. We measure the anthropometric parameters and test motor abilities of 160 school students of the city of Tambov at the age of 15. We conduct a correlation and regression analysis of the relationship of individual anthropometric characteristics (body length and weight, chest circumference and chest excursion) and motor abilities (speed, speed-strength, strength, coordination, general endurance and flexibility). As among boys, and among girls we reveal a direct distinctive and statistically significant correlation between body length and speed and coordinating abilities, as well as general endurance. Body weight of school students did not have a pronounced and statistically significant relationship with motor abilities. The circumference of the chest and excursion of the chest in young men had a pronounced, statistically significant relationship with the level of development of all the analyzed motor is capable of power. In girls the correlation was either not sufficiently, or had a different direction that indicates the absence interdependence. The obtained data allow to build a targeted strategy of development of motor abilities of adolescents on the lessons of physical culture at comprehensive school. The results of the study can be used by coaches in sports clubs for sports selection and sports orientation.

scholarly journals Young Women's HDL Cholesterol Changes Differ by Parity Status, Race and Pre-Pregnancy HDL

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1104-1104
Author(s):  
Jessica Woo ◽  
Laura Woollett
Keyword(s):  
Young Women ◽  
Secondary Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Health Study ◽  
Funding Sources ◽  
Concentration Changes ◽  
C 50 ◽  
Relationship Of ◽  
The Relationship

Abstract Objectives Longitudinal analyses have identified that first pregnancy is associated with a 3–4 mg/dl selective decrease in high-density lipoprotein-cholesterol (HDL-C) concentration. This study examined whether HDL-C concentration changes vary by pre-pregnancy demographic or cardiometabolic factors. Methods This is a secondary analysis of the NHLBI Growth and Health Study in which girls were studied from 9 to 29 years of age. Girls with lipid measurements prior to (mean age ∼17) and after (mean age ∼23) their first birth (parous) were compared with a nulliparous group with lipid assessments at similar ages (∼16 and ∼25 years). Results 202 nulliparous and 199 parous participants were analyzed (52% black, mean age 16.6 at initial measurement). The parous group was more likely to be black (66% vs. 38%, P &lt; 0.0001), but did not differ on initial BMI, % body fat, or HDL-C. HDL-C change was not related to gestational factors (gestational weight gain, infant birthweight (both P &gt; 0.3)). Adjusting for concurrent change in BMI, race and time between measurements, the parous group HDL-C decreased by −3.4 mg/dl while the nulliparous HDL-C did not change (−0.1 mg/dl, P = 0.004 for difference). Adjusted HDL-C changes were negatively associated with initial HDL-C (beta: −0.42, P &lt; 0.0001), but not with initial BMI (P = 0.13) or age (P = 0.18). Parity status and race altered the relationship of initial HDL-C with changes in HDL-C (p for 3-way interaction &lt;0.05). In particular, whites with initial HDL-C ≥ 50 mg/dl experienced pregnancy-specific decreases in HDL-C (−7.0 mg/dl parous vs. no significant change in nulliparous, P &lt; 0.0001). In blacks with initial HDL-C ≥ 50 mg/dl, HDL-C significantly declined in both the parous (−6.9 mg/dl) and nulliparous (−5.4 mg/dl) groups (P = 0.35 for parity difference). In women of both races with low initial HDL-C (&lt;50 mg/dl), HDL-C increased or did not change. Conclusions Young adult changes in HDL are not associated with gestational factors, but are strongly associated with race, parity status, changes in BMI and initial HDL. In particular, white young women with high HDL experience major pregnancy-related decreases in HDL, while black young women with high HDL are at risk of significant HDL declines, regardless of parity. Impacts on cardiometabolic outcomes should be examined. Funding Sources NIH/NHLBI.

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