scholarly journals Non-prescription proton-pump inhibitors for self-treating frequent heartburn: the role of the Canadian pharmacist

2016 ◽  
Vol 14 (4) ◽  
pp. 868 ◽  
Author(s):  
David Armstrong ◽  
Nardine Nakhla
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Frequent Heartburn

scholarly journals Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

2021 ◽  
Vol 22 (24) ◽  
pp. 13609
Author(s):  
Lucas Wauters ◽  
Raúl Y. Tito ◽  
Matthias Ceulemans ◽  
Maarten Lambaerts ◽  
Alison Accarie ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Role ◽  
Short Term ◽  
Beneficial Effects ◽  
Rrna Sequencing ◽  
Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

scholarly journals Role of altered esophageal intraluminal baseline impedance levels in patients with gatroesophageal reflux disease refractory to proton pump inhibitors

Medicine ◽  
2016 ◽  
Vol 95 (33) ◽  
pp. e4351 ◽  
Author(s):  
Liuqin Jiang ◽  
Bixing Ye ◽  
Lin Lin ◽  
Ying Wang ◽  
Meifeng Wang
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Reflux Disease

Small-bowel bacterial overgrowth

2010 ◽  
pp. 2330-2334
Author(s):  
Richard A. Schatz ◽  
Phillip P. Toskes
Keyword(s):  
Small Bowel ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case History ◽  
Diagnostic Tool ◽  
Bacterial Overgrowth ◽  
Breath Tests ◽  
Small Bowel Bacterial Overgrowth ◽  
History Of

Case History—A 78 yr old woman presenting with a five-year history of diarrhoea. Updates Pathogenesis—discussion of the possible role of proton pump inhibitors. Diagnosis—comparison of lactulose hydrogen, glucose hydrogen, and 14C D-xylose breath tests; preliminary studies of circulating CdtB antibodies as a diagnostic tool....

P.04.25 ROLE OF CYP2C19*17 AND CYP2C19*2 IN THE RESPONSE TO PROTON PUMP INHIBITORS TREATMENT IN PATIENTS WITH ESOPHAGITIS

2013 ◽  
Vol 45 ◽  
pp. S118-S119
Author(s):  
M. Franceschi ◽  
D. Seripa ◽  
P. Giulia ◽  
S. Bazzano ◽  
C. Gravina ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump

The Role of Proton Pump Inhibitors on Early Mycophenolic Acid Exposure in Kidney Transplantation: Evidence From the CLEAR Study

2011 ◽  
Vol 33 (1) ◽  
pp. 120-123 ◽  
Author(s):  
Bryce A Kiberd ◽  
Michelle Wrobel ◽  
Raymond Dandavino ◽  
Paul Keown ◽  
Sita Gourishankar
Keyword(s):  
Kidney Transplantation ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Mycophenolic Acid ◽  
Acid Exposure

scholarly journals Clinical Manifestations and Role of Proton Pump Inhibitors in the Management of Laryngopharyngeal Reflux

2011 ◽  
Vol 63 (2) ◽  
pp. 182-189 ◽  
Author(s):  
Suhail Amin Patigaroo ◽  
S. F. Hashmi ◽  
Syed Abrar Hasan ◽  
M. R. Ajmal ◽  
Nazia Mehfooz
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Clinical Manifestations
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