scholarly journals An unusual case of Hyalohyphomycosis due to Purpureocillium lilacinum in a patient with Myasthenia gravis

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
Ramya Raghavan ◽  
Gomathi Chithra ◽  
Sanal Fernandez ◽  
Bettadpura Shamana Suryanarayana ◽  
Rakesh Singh
Keyword(s):  
Myasthenia Gravis ◽  
Unusual Case ◽  
Immunocompromised Patient ◽  
Fungal Growth ◽  
Surgical Excision ◽  
Lower Limbs ◽  
Unusual Site ◽  
Purpureocillium Lilacinum ◽  
Uncontrolled Diabetes ◽  
Alternative Treatment Option

Background and Purpose: Purpureocillium lilacinum (previously known as Paecilomyces lilacinus) and Paecilomyces variotii cause hyalohyphomycosis.Case report: In this study, we present a case of multiple subcutaneous abscesses of the lower limbs due to Purpureocillium lilacinum in a patient with myasthenia gravis and uncontrolled diabetes. Subcutaneous involvement of the lower limbs with this fungus is an unusual presentation. Pus aspirate collected on multiple occasions revealed hyaline septate hyphae under microscopic examination and Purpureocillium lilacinum grew on Sabouraud Dextrose Agar. The patient was initially treated by surgical excision and itraconazole therapy. Swelling regressed but discharge was noticed from the excision site after three months of itraconazole therapy. Culture from the discharge material yielded the same fungal growth. Treatment was changed to ketoconazole and he responded. Conclusion: This case report emphasizes the importance of identifying Purpureocillium lilacinum at an unusual site like the lower limbs in an immunocompromised patient. Ketoconazole may be used as an alternative treatment option for hyalohyphomycosis caused by Purpureocillium lilacinum. Keywords: Hyalohyphomycosis, Immunocompromised patient, Myasthenia gravis, Purpureocillium lilacinum, Purpureocillium lilacinum  

scholarly journals Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

2006 ◽  
Vol 5 (7) ◽  
pp. 1091-1103 ◽  
Author(s):  
William J. Steinbach ◽  
Robert A. Cramer ◽  
B. Zachary Perfect ◽  
Yohannes G. Asfaw ◽  
Theodor C. Sauer ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Clinical Observation ◽  
Immunocompromised Patient ◽  
Fungal Growth ◽  
Pathogenic Fungi ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Growth Morphology ◽  
Different Types ◽  
Hyphal Morphology

ABSTRACT Calcineurin is implicated in a myriad of human diseases as well as homeostasis and virulence in several major human pathogenic microorganisms. The fungus Aspergillus fumigatus is a leading cause of infectious death in the rapidly expanding immunocompromised patient population. Current antifungal treatments for invasive aspergillosis are often ineffective, and novel therapeutic approaches are urgently needed. We demonstrate that a mutant of A. fumigatus lacking the calcineurin A (cnaA) catalytic subunit exhibited defective hyphal morphology related to apical extension and polarized growth, which resulted in drastically decreased filamentation. The ΔcnaA mutant lacked the extensive lattice of invading hyphae seen with the wild-type and complemented strains. Sporulation was also affected in the ΔcnaA mutant, including morphological conidial defects with the absence of surface rodlets and the added presence of disjunctors creating long conidial chains. Infection with the ΔcnaA mutant in several distinct animal models with different types of immunosuppression and inoculum delivery led to a profound attenuation of pathogenicity compared to infection with the wild-type and complemented strains. Lung tissue from animals infected with the ΔcnaA mutant showed a complete absence of hyphae, in contrast to tissue from animals infected with the wild-type and complemented strains. Quantitative fungal burden and pulmonary infarct scoring confirmed these findings. Our results support the clinical observation that substantially decreasing fungal growth can prevent disease establishment and decrease mortality. Our findings reveal that calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention.

scholarly journals Schwannoma of the Submandibular Gland

2020 ◽  
Vol 28 (1) ◽  
pp. 80-83
Author(s):  
Dechu Muddaiah ◽  
Srinivas Venkatarangaiah ◽  
Prashanth V ◽  
Mohammed Adil Hussain M
Keyword(s):  
Submandibular Gland ◽  
Unusual Case ◽  
Surgical Excision ◽  
Good Prognosis ◽  
Total Excision ◽  
Rare Form ◽  
Neurogenic Tumour ◽  
Mesenchymal Tumours ◽  
Submandibular Gland Excision ◽  
Histopathologic Features

Introduction Mesenchymal tumours of submandibular gland are extremely rare. Schwannoma of the salivary glands is a particularly rare form of an extracranial neurogenic tumour.  Case Report Here, we present an unusual case of schwannoma of submandibular gland in a 16 year old girl, who underwent total excision of mass with submandibular gland excision with no cranial nerve deficits. The details of the histopathologic features are present .   Discussion Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumour. Our case indicates good prognosis in a case of submandibular gland schwannoma after surgical excision.

scholarly journals An unusual case of genital filariasis of the testicular tunics in an Italian patient

2021 ◽  
Vol 41 (3) ◽  
pp. 186-189
Author(s):  
Alessia Fassari ◽  
Andrea Polistena ◽  
Giorgio De Toma ◽  
Enrico Fiori
Keyword(s):  
Medical Treatment ◽  
Adult Worm ◽  
Clinical Examination ◽  
Unusual Case ◽  
Surgical Excision ◽  
Singular Case ◽  
Short Term ◽  
Italian Patient ◽  
Immigrant Patient ◽  
Endemic Areas

At least 27 million men present with urogenital manifestations of genital filariasis (GF). Although there is a large burden of GF in residents in endemic regions, infection in short-term travellers and in non-endemic areas is rare. We report the case of a 75-year-old Italian man referred to our institution for a testicular discomfort. Clinical examination and ultrasound detected a mass of 40×18 mm in the scrotum without signs of varicocele, hydrocele and testicular or epididymal abnormalities. After ineffective medical treatment, the patient underwent surgical excision. Histology demonstrated filarial granuloma with thick cuticles pathognomonic of an adult worm in the testicular tunics. Surgery has a fundamental role in localized cases of GF to remove nematodes from the fibrotic nodules. The present manuscript describes a singular case of GF observed in Italy in a non-immigrant patient with evidence of remnants of an adult worm in the testicular tunics. SIMILAR CASES PUBLISHED: 11

Meatoplasty keloid: a rare lesion treated with an unusual surgical approach

2006 ◽  
Vol 120 (7) ◽  
pp. 594-596
Author(s):  
N P Shine ◽  
K Lew
Keyword(s):  
Unusual Case ◽  
Steroid Injection ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Mastoid Cavity ◽  
Ear Piercing ◽  
Keloid Scarring ◽  
Microscopic Evaluation ◽  
Keloid Formation ◽  
Rare Lesion

Keloid scarring is a benign hyperproliferation of fibrous tissue occurring at a wound healing site. Keloid formation related to the ear is generally the result of ear-piercing, mainly causing cosmetic disfigurement. We present an unusual case of keloid formation at a previous meatoplasty incision scar in a 10-year-old Caucasian with a modified radical mastoid cavity. This lesion prevented the cavity from self-cleaning and obstructed microscopic evaluation of the cavity. Treatment was successfully performed by surgical excision, with closure of the defect using supra-keloid skin flaps, followed by serial steroid injection therapy.

scholarly journals Iatrogenic Inflammatory Fibrosis of Hard Palate in a 13-Year-Old Female Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Shanthan Mettu ◽  
Radhika Muppa ◽  
G. Siva Prasad Reddy ◽  
Srinivas Nallanchakrava ◽  
Sri Veda Gurugubelli
Keyword(s):  
Female Patient ◽  
Hard Palate ◽  
Unusual Case ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Inflammatory Cells ◽  
Nerve Tissue ◽  
Rare Occurrence ◽  
Reactive Process ◽  
Tooth Number

Palatal swellings are rare in children and the incidence differs from that of the adult counterparts. When the palatal swellings do arise in children, they usually are palatal abscess from periapical region, and few cases like pleomorphic adenoma in young adults have also been reported. But inflammatory fibrosis of palate in children is a rare occurrence. Inflammatory fibrosis is formation of excess fibrous connective tissue in an organ or tissue, as a reparative or reactive process. This report describes an unusual case of iatrogenic inflammatory fibrosis on the palate due to extraction of tooth number 22 in a 13-year-old female patient. The patient presented with a single large well-circumscribed oval palatal swelling that was soft, fluctuant, not fixed, and nontender. Surgical excision of the lesion was done and it was sent for histopathological assessment. The biopsy showed fibrous tissue with collagen fibers, spindle shaped fibroblasts, neovascularization, RBCs, chronic inflammatory cells, and traces of salivary gland and nerve tissue.

scholarly journals DON’T JUDGE A BOOK BY ITS COVER: UNUSUAL CASE OF MYASTHENIA GRAVIS

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A2012
Author(s):  
Urbee Haque ◽  
Shubham Adroja ◽  
Anthony Cucci
Keyword(s):  
Myasthenia Gravis ◽  
Unusual Case

scholarly journals A New Record for Microbial Perchlorate Tolerance: Fungal Growth in NaClO4 Brines and its Implications for Putative Life on Mars

Life ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 53 ◽  
Author(s):  
Jacob Heinz ◽  
Tim Krahn ◽  
Dirk Schulze-Makuch
Keyword(s):  
Liquid Water ◽  
Sodium Perchlorate ◽  
Debaryomyces Hansenii ◽  
Fungal Growth ◽  
Natural Environments ◽  
Microbial Life ◽  
Purpureocillium Lilacinum ◽  
Halotolerant Yeast ◽  
Colony Forming Units ◽  
Microbial Habitat

The habitability of Mars is strongly dependent on the availability of liquid water, which is essential for life as we know it. One of the few places where liquid water might be found on Mars is in liquid perchlorate brines that could form via deliquescence. As these concentrated perchlorate salt solutions do not occur on Earth as natural environments, it is necessary to investigate in lab experiments the potential of these brines to serve as a microbial habitat. Here, we report on the sodium perchlorate (NaClO4) tolerances for the halotolerant yeast Debaryomyces hansenii and the filamentous fungus Purpureocillium lilacinum. Microbial growth was determined visually, microscopically and via counting colony forming units (CFU). With the observed growth of D. hansenii in liquid growth medium containing 2.4 M NaClO4, we found by far the highest microbial perchlorate tolerance reported to date, more than twice as high as the record reported prior (for the bacterium Planococcus halocryophilus). It is plausible to assume that putative Martian microbes could adapt to even higher perchlorate concentrations due to their long exposure to these environments occurring naturally on Mars, which also increases the likelihood of microbial life thriving in the Martian brines.

scholarly journals Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity

2018 ◽  
Vol 31 (11) ◽  
pp. 693 ◽  
Author(s):  
Suleyman Utku Celik ◽  
Ilkin Hesimov ◽  
Burak Kutlu ◽  
Ayhan Bulent Erkek
Keyword(s):  
Unusual Case ◽  
Surgical Excision ◽  
Complete Resection ◽  
Pelvic Cavity ◽  
Interstitial Tissue ◽  
Aggressive Angiomyxoma ◽  
Soft Tissue Neoplasm ◽  
Fourth Decade ◽  
Male Patients ◽  
Slow Growing

Aggressive angiomyxoma is an uncommon, benign, slow-growing, and locally infiltrative soft tissue neoplasm which is located primarily in the genital region and pelviperineal interstitial tissue of female patient in the fourth decade of life. Its occurrence in male patients is even more unusual and commonly appears at a later age. The mainstay of treatment typically involves surgical excision with tumor-free margins, and despite complete resection, local recurrences are common. Here, an unusual case of aggressive angiomyxoma occurring in the pelvic region of a 55-year-old man and its treatment is discussed due to its rarity.

Distal phalanx: an unusual site for a gastric adenocarcinoma metastasis

2020 ◽  
Vol 13 (9) ◽  
pp. e236259
Author(s):  
Holly Harris ◽  
Mansoor Khan ◽  
Shameen Jaunoo
Keyword(s):  
Gastric Adenocarcinoma ◽  
Metastatic Disease ◽  
Unusual Case ◽  
Distal Phalanx ◽  
Unusual Site

Gastric adenocarcinoma typically metastasises to the liver, peritoneum and lung. Bone metastasises are less frequent and particularly uncommon in the distal extremities. This is an unusual case of metastatic disease in the distal phalanx mimicking the presentation of osteomyelitis. This case highlights the need to remain vigilant in patients with known cancer and to always be mindful of metastatic disease, even if the presentation is atypical.

scholarly journals Large Complex Odontoma of Mandible in a Young Boy: A Rare and Unusual Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
G. Siva Prasad Reddy ◽  
G. V. Reddy ◽  
B. Sidhartha ◽  
K. Sriharsha ◽  
John Koshy ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Unusual Case ◽  
Facial Asymmetry ◽  
Surgical Excision ◽  
Radiographic Examination ◽  
Rare Tumor ◽  
Complex Odontoma ◽  
Compound Odontoma ◽  
Unusual Case Report

Odontomas are the most common odontogenic tumors. They are broadly classified in to Compound Odontoma and Complex Odontoma. Among them complex odontoma is a rare tumor. Occasionally this tumor becomes large, causing expansion of bone followed by facial asymmetry. Otherwise these tumors are asymptomatic and are generally diagnosed on radiographic examination. We report a rare case of complex odontoma of mandible in a young boy. The tumor was treated by surgical excision under general anesthesia.

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