scholarly journals Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study

2021 ◽  
Vol 24 ◽  
pp. 191-199
Author(s):  
Delaram Hossein Mostafa ◽  
Aniseh Samadi ◽  
Somayeh Niknam ◽  
Saman Ahmad Nasrollahi ◽  
Alexandre Guishard ◽  
...  
Keyword(s):  
Hair Growth ◽  
Prostaglandin F2α ◽  
Treatment Phase ◽  
Growth Cycle ◽  
Controlled Study ◽  
Prostaglandin E ◽  
Prostaglandin D2 ◽  
Hair Density ◽  
Anagen Phase ◽  
Two Phases

Purpose: Prostaglandins play a pivotal role in modulating hair growth cycle. Prostaglandin F2α and prostaglandin E have stimulating and prostaglandin D has inhibitory effects on hair follicle. Cetirizine inhibits release of prostaglandin D2 and stimulates the release of prostaglandin E2. In the present study, the efficacy and safety of twice daily application of topical cetirizine 1% versus minoxidil 5% solutions for 16 weeks were compared in male androgenetic alopecia (AGA). Methods: Forty men, aged 18 to 49 years, ‎were randomly divided into two equal groups to apply either cetirizine 1% or minoxidil 5% solutions. The study was divided into two phases, a 16-week treatment phase either with cetirizine or minoxidil (anagen phase), followed by an 8-week ‎ drug-free (telogen phase) with a follow-up when patients used placebo. Efficacy outcomes included the change in total hair density, vellus and terminal hair density, hair diameter and the percentage of hair in anagen and telogen phases from baseline in 16 and 24 weeks. Results: After 16 weeks, we observed a significant increase in total and vellus hair density in both minoxidil and cetirizine groups, but the improvement was much higher in the minoxidil group. The percentage of hair in the anagen phase also increased in both groups after 16 weeks of treatment, but then diminished after 8 weeks of placebo consumption. No significant adverse reactions associated with the administration of cetirizine solution were reported. Conclusion: Cetirizine 1% solution was effective in hair growth without any complications for treatment of male AGA.

scholarly journals Role of proteoglycans in the treatment of alopecia of various genesis

2021 ◽  
pp. 347-351
Author(s):  
L. R. Sakaniya ◽  
O. O. Melnichenko ◽  
A. L. Piruzyan ◽  
I. M. Korsunskaya
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Growth Cycle ◽  
Strong Impact ◽  
Natural Hair ◽  
Number Of Patients ◽  
Anagen Phase ◽  
Life Threatening ◽  
Specific Proteins

Hair loss has always been and remains an urgent challenge in the world today. Although this condition is not life-threatening, it still has a strong impact on the patients’ quality of life. Hairlines are affected by multiple factors including age, family history, smoking, nutrition, etc. Alopecia can take many forms, and the specialist’s objective is to determine the correct cause of the disorder of hair growth cycle by taking a medical history from a patient.The key role in the pathogenesis of androgenetic alopecia is assigned to changes in hormonal status. Telogen effluvium can be triggered by stress, medication, pregnancy, or other medical conditions. For instance, the high number of patients who have had COVID-19 are now faced with hair loss a few months after recovery.Despite the variety of underlining causes of hair loss, the principle of therapy is the same – the elimination of the trigger and the selection of drugs to normalize the natural hair growth cycle. In this case, the use of drugs containing proteoglycans that are specific proteins involved in the regulation of the hair growth cycle looks promising. Numerous studies demonstrate the efficacy of such proteoglycans as versican, decorin, and syndecan. They activate hair growth and help prolong the anagen phase. This effect of proteoglycans affords to speak about their good therapeutic and even prophylactic properties applied to the problem of hair loss. 

scholarly journals Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jing-jie Li ◽  
Zheng Li ◽  
Li-juan Gu ◽  
Yun-bo Wang ◽  
Mi-ra Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Aqueous Extract ◽  
Hair Growth ◽  
Red Deer ◽  
Growth Parameters ◽  
Hair Follicles ◽  
Control Group ◽  
Deer Antler ◽  
Vehicle Control Group ◽  
Anagen Phase

Deer antlers are the only mammalian appendage capable of regeneration. We aimed to investigate the effect of red deer antler extract in regulating hair growth, using a mouse model. The backs of male mice were shaved at eight weeks of age. Crude aqueous extracts of deer antler were prepared at either 4°C or 100°C and injected subcutaneously to two separate groups of mice (n=9) at 1 mL/day for 10 consecutive days, with water as a vehicle control group. The mice skin quantitative hair growth parameters were measured and 5-bromo-2-deoxyuridine was used to identify label-retaining cells. We found that, in both the 4°C and the 100°C deer antler aqueous extract-injection groups, the anagen phase was extended, while the number of BrdU-incorporated cells was dramatically increased. These results indicate that deer antler aqueous extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.

scholarly journals Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

2001 ◽  
Vol 116 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Jonathan J. Bull ◽  
Sven Mïller-Röver ◽  
Sejal V. Patel ◽  
Catherine M.T. Chronnell ◽  
Ian A. McKay ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Growth Cycle ◽  
Human Hair Follicle

GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

1996 ◽  
Vol 14 (4) ◽  
pp. 559-572 ◽  
Author(s):  
Dominik Peus ◽  
Mark R. Pittelkow
Keyword(s):  
Growth Factors ◽  
Hair Growth ◽  
Growth Cycle ◽  
Organ Development
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