scholarly journals Assessing the Physicochemical Stability of a Compounded Neonatal Trace Element Solution

2018 ◽  
Vol 21 (1s) ◽  
pp. 103s-116s
Author(s):  
Forugh Sanaee ◽  
Tania Mysak ◽  
Laurine Sanderson ◽  
Theresa Donaldson ◽  
Mohammad Reza Vakili ◽  
...  
Keyword(s):  
Trace Element ◽  
Zinc Sulfate ◽  
Room Temperature ◽  
Sodium Iodide ◽  
Iodine Concentration ◽  
Storage Conditions ◽  
Element Formulation ◽  
Icp Ms ◽  
Physicochemical Stability ◽  
Trace Element Solution

PURPOSE: Alberta Health Services (AHS) recommends the adoption of a new neonatal multi-trace element formulation containing zinc sulfate, copper sulfate, selenious acid and sodium iodide to be compounded internally in appropriate AHS pharmacies. The objective of this study was to assess the physicochemical stability of this formulation under commonly used storage conditions. METHOD:  Three batches of trace element solution were compounded by University of Alberta Hospital pharmacy staff using sterile compounding procedures. Appropriate amount of zinc sulfate (500 mg/mL), copper sulfate (40 mg/mL), selenious acid (4 mg/mL), sodium iodide (2 mg/mL) and sterile water for injection were mixed. Samples from each batch were divided in individual vials and syringes for each time point and kept protected from light either at room temperature (15–30°C) or fridge (2-8°C). Vial samples were also kept at room temperature for 12 h and then transferred to fridge. Vial samples were analyzed at time 0, 12 h, and 1, 3, 7, 9, 30, 60, 90 days for their physical appearance and pH, then centrifuged and assessed for the soluble zinc (atomic absorption), copper (atomic absorption), selenium (ICP-MS) and iodine (HPLC and ICP-MS) concentrations. Syringe samples were tested at time 0 and 12 h for element concentrations. RESULTS: Under all storage conditions, when stored in vials, samples’ appearance, pH and soluble zinc, copper and selenium concentrations stayed within the USP acceptable limits up to 90 days. Iodine concentration was within the permitted limits only up to 7 days. The USP recommended HPLC method of iodine analysis seemed inadequate for this preparation and needed modifications, through frequent washing of the column with KI (2 %) solution. Samples kept in syringes at room temperature, showed lower than permitted concentration of Zn at 12h in this study. CONCLUSION: The AHS neonatal multi-trace element formulation seem to be physio-chemically stable up to 7 days in all three storage conditions when kept in vials.  A decline in iodine concentration is seen after 7 days irrespective of storage conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

TRACE ELEMENT ANALYSIS OF PYRITES IN GAS SHALES BY LASER ABLATION ICP-MS: IMPLICATIONS FOR MOBILITY

2017 ◽  
Author(s):  
Amy K. Plechacek ◽  
◽  
Madeline E. Schreiber ◽  
John A. Chermak ◽  
Tracy L. Bank
Keyword(s):  
Laser Ablation ◽  
Trace Element ◽  
Trace Element Analysis ◽  
Element Analysis ◽  
Icp Ms ◽  
Gas Shales

scholarly journals Enhanced preservation of vacuum-packaged Atlantic salmon by hyperbaric storage at room temperature versus refrigeration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liliana G. Fidalgo ◽  
Mário M. Q. Simões ◽  
Susana Casal ◽  
José A. Lopes-da-Silva ◽  
Ivonne Delgadillo ◽  
...  
Keyword(s):  
Atlantic Salmon ◽  
Microbial Activity ◽  
Room Temperature ◽  
Energy Savings ◽  
Textural Properties ◽  
Storage Conditions ◽  
Volatile Profile ◽  
Fragmentation Index ◽  
C 30 ◽  
Water Holding

AbstractHyperbaric storage at room temperature (HS/RT: 75 MPa/25 °C) of vacuum-packaged fresh Atlantic salmon (Salmo salar) loins was studied for 30 days and compared to atmospheric pressure at refrigerated temperatures (AP/5 °C, 30 days) and RT (AP/25 °C, 5 days). Most of the fatty acids were not affected by storage conditions, with only a slight decrease of docosahexaenoic acid (DHA) content (n-3 polyunsaturated fatty acid) for AP samples, reflected in the lower polyene index values obtained and higher oxidation extent. For HS, a lower lipid oxidation extension and a slower increase of myofibrillar fragmentation index values were observed, when compared to AP samples. The volatile profile was similar for the HS and fresh samples, with the HS samples retaining fresh-like alcohols and aldehydes components, which disappeared in AP samples, mainly in AP/25 °C samples. The volatile profile for AP samples (5 and 25 °C) revealed mostly spoilage-like compounds due to microbial activity. Drip loss increased progressively during the 30 days of storage under HS, while a slight decrease of water holding capacity after 5 days was observed, increasing further after 30 days. Regarding textural properties, only resilience was affected by HS, decreasing after 30 days. So, HS/RT could represent an interesting extended preservation methodology of fresh salmon loins, since allows retaining important physicochemical properties for at least 15 days, while refrigeration after 5 days showed already volatile spoilage-like compounds due to microbial activity. Furthermore, this methodology allows additional considerable energy savings when compared to refrigeration.

LA-ICP-MS U Pb columbite ages and trace-element signature from rare-element granitic pegmatites of the Pampean Pegmatite Province, Argentina

Lithos ◽  
2021 ◽  
Vol 386-387 ◽  
pp. 106001
Author(s):  
Miguel Ángel Galliski ◽  
Albrecht von Quadt ◽  
María Florencia Márquez-Zavalía
Keyword(s):  
Trace Element ◽  
Rare Element ◽  
Granitic Pegmatites ◽  
Icp Ms ◽  
Trace Element Signature

scholarly journals Geochemical signatures of mineralizing events in the Juomasuo Au–Co deposit, Kuusamo belt, northeastern Finland

2021 ◽  
Author(s):  
Mikael Vasilopoulos ◽  
Ferenc Molnár ◽  
Hugh O’Brien ◽  
Yann Lahaye ◽  
Marie Lefèbvre ◽  
...  
Keyword(s):  
Trace Element ◽  
Sulfur Isotope ◽  
Mineral Chemistry ◽  
Chemical Compositions ◽  
Metasedimentary Rocks ◽  
Metavolcanic Rocks ◽  
Icp Ms ◽  
Stage 1 ◽  
Host Rocks ◽  
Relationship Of

AbstractThe Juomasuo Au–Co deposit, currently classified as an orogenic gold deposit with atypical metal association, is located in the Paleoproterozoic Kuusamo belt in northeastern Finland. The volcano-sedimentary sequence that hosts the deposit was intensely altered, deformed, and metamorphosed to greenschist facies during the 1.93–1.76 Ga Svecofennian orogeny. In this study, we investigate the temporal relationship between Co and Au deposition and the relationship of metal enrichment with protolith composition and alteration mineralogy by utilizing lithogeochemical data and petrographic observations. We also investigate the nature of fluids involved in deposit formation based on sulfide trace element and sulfur isotope LA-ICP-MS data together with tourmaline mineral chemistry and boron isotopes. Classification of original protoliths was made on the basis of geochemically immobile elements; recognized lithologies are metasedimentary rocks, mafic, intermediate-composition, and felsic metavolcanic rocks, and an ultramafic sill. The composition of the host rocks does not control the type or intensity of mineralization. Sulfur isotope values (δ34S − 2.6 to + 7.1‰) and trace element data obtained for pyrite, chalcopyrite, and pyrrhotite indicate that the two geochemically distinct Au–Co and Co ore types formed from fluids of different compositions and origins. A reduced, metamorphic fluid was responsible for deposition of the pyrrhotite-dominant, Co-rich ore, whereas a relatively oxidized fluid deposited the pyrite-dominant Au–Co ore. The main alteration and mineralization stages at Juomasuo are as follows: (1) widespread albitization that predates both types of mineralization; (2) stage 1, Co-rich mineralization associated with chlorite (± biotite ± amphibole) alteration; (3) stage 2, Au–Co mineralization related to sericitization. Crystal-chemical compositions for tourmaline suggest the involvement of evaporite-related fluids in formation of the deposit; boron isotope data also allow for this conclusion. Results of our research indicate that the metal association in the Juomasuo Au–Co deposit was formed by spatially coincident and multiple hydrothermal processes.

Trace Element Mapping of Copper- and Zinc-Rich Black Smoker Chimneys from Brothers Volcano, Kermadec Arc, Using Synchrotron Radiation XFM and LA-ICP-MS

2019 ◽  
Vol 114 (1) ◽  
pp. 67-92 ◽  
Author(s):  
H. A. Berkenbosch ◽  
C.E.J. de Ronde ◽  
C. G. Ryan ◽  
A. W. McNeill ◽  
D. L. Howard ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Trace Element ◽  
Black Smoker ◽  
Copper And Zinc ◽  
Icp Ms ◽  
Element Mapping
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