Background:
Natural products and their derived phytochemicals have been used in the medicine and gaining importance in the modern medicine due to their therapeutic potential and health beneficial effect on human disorders. Plenty of herbal drug based products are available in the market and playing an important role in the human health care system due to their health beneficial properties in human being. In the modern age we can find many herbal based products in the market mainly prepared from the natural products and used for the prevention and treatment of various human disorders. Benzylisoquinoline alkaloids are the important class of alkaloidal compounds and the better example are morphine, codeine, sanguinarine, berberine and canadine which are mainly known for their medicinal value in the medicine.
Methods:
Hydrastis canadensis is the important medicinal plant found to contain a significant amount of canadine, hydrastine and berberine. In the present investigation, numerous scientific databases such as Google, Pubmed, Science direct etc. have been searched to collect the important scientific information of canadine and analyzed to know the health beneficial aspect of canadine in the medicine. All the collected scientific information data’s were analyzed and have been categorized into mainly pharmacological and analytical aspects.
Results:
From the analysis of the collected scientific information, it was found that Hydrastis canadensis contain significant amount of canadine with many more phytochemical including canadaline, hydrastidine, isohydrastidine etc. Pharmacological activity data analysis revealed the biological importance of Hydrastis canadensis in the medicine for their traditional uses against gastritis, colitis, duodenal ulcers, loss of appetite, liver disease, bile secretion disorder, snake bites and vaginitis in the medicine. However, scientific data analysis of canadine revealed their effectiveness for their acetylcholinesterase inhibitory activity, anti-cancer, anti-microbial, anti-allergic activity and anti-oxidant activity. Different modern analytical tools have been used in the modern medicine for the isolation and quantification of canadine in the Hydrastis canadensis.
Conclusion:
Present investigation revealed the medicinal importance and pharmacological activities of a canadine in the medicine for the treatment of numerous human health complications. These scientific data will be helpful to the scientist to know the biological importance of canadine in the medicine against various forms of human complications.
Proceedings of conference on Mechanism-Based Development of Natural Products for Human Health