scholarly journals Incidence of Vitamin B12 Deficiency in Patients with Hypothyroidism

2021 ◽  
Vol 8 (8) ◽  
pp. 415-419
Author(s):  
Priyadarshini Raju ◽  
Shreyas Kumar V
Keyword(s):  
Vitamin B12 ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Adult Population ◽  
Vitamin B12 Deficiency ◽  
Thyroid Function Test ◽  
Autoimmune Thyroid ◽  
Medical College ◽  
B12 Deficiency ◽  
Hypothyroid Patients

BACKGROUND Hypothyroidism is a common endocrine disorder which affects 11 % of the adult population in western countries. Hypothyroidism can cause a wide variety of anaemic disorders. Patients with both hypothyroidism and Vitamin B12 deficiency also have similar symptoms. Thus, this study was conducted to evaluate the relationship between the two and also hypothyroidism due to autoimmune cause. METHODS This was a descriptive study of 50 newly detected hypothyroid patients from Rajarajeswari Medical College evaluated for vitamin B12 deficiency. The study was conducted between January 10th 2019 to July 21st 2019. Lab parameters analysed included haemoglobin, thyroid function test (TFT), vitamin B12 levels and antithyroid peroxidase (anti-TPO) antibody levels. RESULTS Of the 50 hypothyroid patients evaluated, 23 were males and 27 were females between the age of 18 to 70 years. Anti TPO antibodies were present in 24 patients (48 %) out of 50, out of which 17 (70 %) patients had vitamin B12 deficiency. Out of 50 hypothyroid patients, 26 patients (52 %) had vitamin B12 deficiency. Thus hypothyroidism and autoimmune thyroid disease was associated with Vitamin B12 deficiency which was statistically significant. CONCLUSIONS Patients with hypothyroidism were studied for the incidence of deficiency of vitamin B12. It was found that 26 of 50 (52 %) patients had low B 12 levels. Incidence in females (54 %) was more than in males (46 %). Our study showed association between hypothyroidism and vitamin B12 deficiency and also autoimmune thyroid disease. KEYWORDS Hypothyroidism, Autoimmune Thyroid Disease, Vitamin B12 Deficiency

Prevalence and Evaluation of B12 Deficiency in Patients with Autoimmune Thyroid Disease

2006 ◽  
Vol 332 (3) ◽  
pp. 119-122 ◽  
Author(s):  
Rosane Ness-Abramof ◽  
Dan A. Nabriski ◽  
Menachem S. Shapiro ◽  
Louis Shenkman ◽  
Lotan Shilo ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
B12 Deficiency

scholarly journals Hipotiroidismo primario, déficit de vitamina B12 y tiroiditis subaguda sobreagregada: informe de caso

2017 ◽  
Vol 2 (4) ◽  
pp. 51-54
Author(s):  
Carlos Alfonso Builes Barrera ◽  
María Gabriela García Orjuela
Keyword(s):  
Vitamin B12 ◽  
Replacement Therapy ◽  
Thyroid Disease ◽  
Vitamin B12 Deficiency ◽  
Primary Hypothyroidism ◽  
Subacute Thyroiditis ◽  
Normal Range ◽  
Hormonal Replacement ◽  
B12 Deficiency ◽  
Over Time

El hipotiroidismo primario es la patología tiroidea más frecuente. El manejo estándar de esta enfermedad es con levotiroxina, cuya absorción puede verse afectada por distintas condiciones médicas, medicamentos e incluso la dieta del paciente. Los requerimientos de levotiroxina podrían variar debido a factores sobre agregados como la tiroiditis subaguda, la deficiencia de vitamina B12 y el uso de medicamentos, elementos que afectan el control del hipotiroidismo. Se presenta el caso de una paciente con hipotiroidismo primario con necesidad de ajuste en la dosis de levotiroxina a través del tiempo debido a comorbilidades agregadas. Se presentan claves para la evaluación del paciente con dificultad para lograr una TSH dentro del rango normal.Abstract Hypothyroidism is the most common thyroid disease. This disease is managed with hormonal replacement therapy using levothyroxine, whose absorption can be affected by various medical conditions, drugs and even patient´s diet. Levothyroxine requirements could vary according to co-morbidities such as subacute thyroiditis, vitamin B12 deficiency and the use of drugs, factors that can affect the control of hypothyroidism. The case of a patient with primary hypothyroidism who required dose adjustments of levothyroxine over time due to added co-morbidities is presented. Clues are given for evaluation of the patient with difficulty in achieving maintenance of TSH within the normal range. 

Thyroid Disease in Pregnancy

2008 ◽  
Vol 04 (01) ◽  
pp. 100
Author(s):  
N Pearce Elizabeth ◽  
M Leung Angela
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Autoimmune Thyroid ◽  
Thyroid Screening ◽  
Function Test ◽  
In Pregnancy

The spectrum of thyroid disease in pregnancy has implications for both the mother and the developing fetus. Here we review the interpretation of thyroid function test values, thyrotoxicosis, hypothyroidism, iodine requirements, autoimmune thyroid disease, and thyroid screening recommendations as they pertain to pregnant women. It should be noted that the management of thyroid dysfunction in pregnancy should be closely co-ordinated with obstetricians and other providers.

scholarly journals VITAMIN B12 DEFICIENCY

2018 ◽  
Vol 25 (05) ◽  
pp. 753-758
Author(s):  
Arshad Sattar Lakho ◽  
Aqeel Ahmed Channa ◽  
Abdul Ghaffar Dars ◽  
Syed Zulfiquar Ali Shah ◽  
Muhammad Iqbal
Keyword(s):  
Vitamin B12 ◽  
Urban Areas ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
University Hospital ◽  
Cross Sectional ◽  
Male Predominance ◽  
B12 Deficiency ◽  
The Mean ◽  
Hypothyroid Patients

Objectives: To determine the frequency of vitamin B12 deficiency in patientswith hypothyroidism. Study Design: Cross sectional descriptive study. Period: 12-05-2016to 11-11-2016. Setting: Liaquat University Hospital Jamshoro / Hyderabad. Patients andMethods: All the patients of known hypothyroid patients for ≥01month duration, 20-50 yearsof age, either gender were explored for serum vitamin B12 level. The SPSS was used tomanipulate the data in relation to mean ±SD, frequencies and percentages and through chisquaretest to get the p-values and its level of significance (≤0.05). Results: Total 145 patientswith hypothyroidism were evaluated for B12 deficiency, of which 97 (66.8%) were males and48 (33.1%) were females respectively. Ninety patients (62%) were from urban areas while 55(37.9%) was rural population. The mean ±SD for age of overall population was 41.83±8.93years while the mean age ±SD for vitamin B12 deficient and non deficient was 39.96±7.82and 40.74±8.54 years respectively. The vitamin B12 deficiency was observed in one hundredand five patients (72%), of which 69 (65.7%) males and 36 (34.3%) females. The mean ± SDfor duration of infection in overall population was 5.32±1.53 months while it was 5.81±1.43 invitamin B12 deficient individuals. Conclusion: The vitamin B12 deficiency is more pronouncedin hypothyroid patients. In present series vitamin B12 deficiency was observed in 105 (72%)individuals with male predominance 69 (65.7%).

Vitamin B12 Deficiency Among the Healthy Jordanian Adult Population: Diagnostic Levels, Symptomology, and Risk Factors

2020 ◽  
Vol 20 ◽  
Author(s):  
Amer Abu-Shanab ◽  
Malek Zihlif ◽  
Momen N. Rbeihat ◽  
Zakaria W. Shkoukani ◽  
Alia Khamis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peptic Ulcer ◽  
Vitamin B12 ◽  
Peptic Ulcer Disease ◽  
Dietary Habits ◽  
Adult Population ◽  
Vitamin B12 Deficiency ◽  
Eastern Region ◽  
Ulcer Disease ◽  
B12 Deficiency

Objective: To explore (a) the risk factors associated with a deficiency of vitamin B12, and (b) the baseline (cutoff) serum level of vitamin B12 for a clinically-symptomatic deficiency in the Jordanian adult population. Background: Compared to the data available for developed countries, there is a marked scarcity of information on the levels and symptomology of vitamin B12 deficiency in developing countries, particularly in the Middle Eastern region. Methods: A total of 485 subjects were included in this study. Blood samples were drawn for biochemical analysis and data regarding socio-demographics, general health, anthropometric measures, and past medical, surgical, and medication history were collected. To explore the cut-off point, we compared all parameters included in a standard complete blood count as well as main symptoms reported to be associated with B12 deficiency between groups of different B12 cut-off values, consisting of those above and below 200, 175, 150 and 125 pg/ml. Results: Dietary habits, age, recurrent headaches, heart burn and peptic ulcer disease were found to be significantly associated with lower vitamin B12 levels. Surprisingly, daily smoking was associated with significantly higher B12 levels. The results revealed that none of the included potential indicators of B12 deficiency could be considered an indicative feature of deficiency. There were no significant differences neither in the symptoms nor in the CBC parameters between any of the tested study groups. Conclusion: Low dietary intake, older ages, recurrent headaches, heartburn and peptic ulcer disease, all could be considered as a risk factors of having low vitamin B12 levels within the Jordanians. Also, they tend to have lower levels of vitamin B12 levels, in comparison to countries in the West, without necessarily having deficiency symptoms. Cut-off value to diagnose functional B12 deficiency could be less than 125 pg/ml for the Jordanians. More local studies are needed to establish an accurate vitamin B12 cut-off value for the population in Jordan.

Prevalence of Vitamin B12 Deficiency in Hypothyroid Patients

2017 ◽  
Vol 11 (3) ◽  
pp. 252-256
Author(s):  
Muhammad Siddique ◽  
Muhammad Akhtar Parvez ◽  
Humaira Zafar ◽  
Awais Mustafa ◽  
Anam Shafi
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Hypothyroid Patients

scholarly journals A study of anemia in hypothyroidism with reference to vitamin B12 deficiency

2019 ◽  
Vol 6 (5) ◽  
pp. 1667
Author(s):  
Palak Bhuta ◽  
Amit Shah ◽  
Arti Muley
Keyword(s):  
Vitamin B12 ◽  
Symptomatic Relief ◽  
Vitamin B12 Deficiency ◽  
Vitamin B ◽  
B12 Deficiency ◽  
Vitamin B 12 ◽  
Larger Sample ◽  
Hypothyroid Patients ◽  
Prevalence Of Anemia

Background: Hypothyroidism is the most common of thyroid disorders in India. Anemia and hypothyroidism often occur simultaneously. Only few studies have assessed the role of vitamin B12 deficiency in this anemia. So, we planned this study to assess prevalence of anemia in hypothyroidism and to see if there is any association between vitamin B12 deficiency and anemia in these patients.Methods: It was an observational study. All hypothyroid patients attending the medicine OPD or admitted to medicine wards were enrolled for the study. Total 60 patients were included. Data was analyzed to assess the burden of anemia and B12 deficiency in hypothyroid and to find out any correlation between TSH level, anemia and vitamin B12 deficiency.).Results: About one third of hypothyroid had decreased vitamin B 12 levels. TSH level showed significant positive correlation with hemoglobin value. 28% of the hypothyroid patients had vitamin b12 deficiency, but TSH levels itself did not correlate with vitamin B12 level. However, it was seen that those who had combined thyroid and B12 deficiency had significantly higher chances of developing generalized swelling and breathlessness.Conclusions: Although there is no correlation between TSH level and B12 deficiency, it may be helpful to determine B12 level in hypothyroid patients who present with anemia, generalized swelling and/or breathlessness as B12 supplementation may give better symptomatic relief in them as compared to treating with thyroxine alone. More elaborative studies with larger sample size are required to explore this rather unattended relation of anemia in hypothyroidism with B12 deficiency.

55: The Risk of Vitamin B12 Deficiency is Low after Ileal Orthotopic Bladder Substitution

2004 ◽  
Vol 171 (4S) ◽  
pp. 15-15
Author(s):  
Urs E. Studer ◽  
Richard Aebischer ◽  
Katharina Ochsner ◽  
Werner W. Hochreiter
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Bladder Substitution

Bioavailability of Vitamin B12

2010 ◽  
Vol 80 (45) ◽  
pp. 330-335 ◽  
Author(s):  
Lindsay Helen Allen
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
The Elderly ◽  
Radioactive Isotopes ◽  
Animal Source Foods ◽  
Dietary Requirements ◽  
In Vivo Labeling ◽  
B12 Deficiency ◽  
Vitamin B12 Malabsorption

Vitamin B12 deficiency is common in people of all ages who consume a low intake of animal-source foods, including populations in developing countries. It is also prevalent among the elderly, even in wealthier countries, due to their malabsorption of B12 from food. Several methods have been applied to diagnose vitamin B12 malabsorption, including Schilling’s test, which is now used rarely, but these do not quantify percent bioavailability. Most of the information on B12 bioavailability from foods was collected 40 to 50 years ago, using radioactive isotopes of cobalt to label the corrinoid ring. The data are sparse, and the level of radioactivity required for in vivo labeling of animal tissues can be prohibitive. A newer method under development uses a low dose of radioactivity as 14C-labeled B12, with measurement of the isotope excreted in urine and feces by accelerator mass spectrometry. This test has revealed that the unabsorbed vitamin is degraded in the intestine. The percent bioavailability is inversely proportional to the dose consumed due to saturation of the active absorption process, even within the range of usual intake from foods. This has important implications for the assessment and interpretation of bioavailability values, setting dietary requirements, and interpreting relationships between intake and status of the vitamin.

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