Clinical and Laboratory Profile of Dengue Fever in the Paediatric Age Group at a Tertiary Care Hospital of West Bengal - A Comparison of Two Subsequent Years

2021 ◽  
Vol 8 (25) ◽  
pp. 2162-2167
Author(s):  
Shankar Sikdar ◽  
Ujjwal Bandyopadhyay ◽  
Sutapa Das ◽  
Mala Bhattacharya
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Warning Signs ◽  
Health Concern ◽  
Care Hospital ◽  
Age Group ◽  
Structural Protein ◽  
Asian Countries ◽  
Paediatric Age

BACKGROUND Dengue is a major public health concern in tropical Asian countries and a most rapidly spreading mosquito borne viral disease with a 30 fold increase in global incidence over the last five decades. Dengue is among the ten leading causes of death in children ranging from 1 to 15 years of age in tropical Asian countries. Complications of dengue fever are common in children. But very limited studies are available on paediatric populations. The virus or non-structural protein (NS1) interacts with platelets and coagulation factors. A combined effect of mild disseminated intravascular coagulation, liver damage and platelet dysfunction results in bleeding in dengue fever. With this scientific knowledge background, the present study was undertaken to identify and document the changing pattern of dengue infection in paediatric age group with a special emphasis on laboratory findings of dengue cases in paediatric age group. METHODS The present descriptive study was conducted for two years in a state run paediatric referral hospital. The sample was purposive by design and consisted of patients who have been diagnosed as having dengue fever with warning signs and admitted. RESULTS Fever was typically high grade (> 103 F) and most patients presented with warning signs within 5 days of illness (64.2 % in year 2016 and 76.6 % in year 2017). Persistent vomiting and abdominal pain were the most common warning signs in both the years. Thrombocytopenia was the commonest laboratory finding. Bleeding in study subjects lead to < 50000 / cu mm platelet count. Most common bleeding was gastrointestinal bleeding (39.2 % of study subjects with platelet count < 50000 / cu mm presented with G. I bleeding). CONCLUSIONS Dengue illness comes with varied presentation. Atypical presentations can delay the diagnosis. Early recognition of warning signs keeping the atypical presentation in mind is important. KEYWORDS Dengue Fever, Paediatric Age Group, Non-Structural Protein (NS1), Thrombocytopenia

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals Epidemiological study of dengue fever in District Swabi, Khyber Pakhtunkhwa, Pakistan

2020 ◽  
Author(s):  
Tahira Qamash ◽  
Johar Jamil ◽  
Faheem Ahmed Khan ◽  
Saira ◽  
Ambareen Sultan ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Serological Test ◽  
Age Groups ◽  
Health Department ◽  
Viral Disease ◽  
Physical Symptoms ◽  
Health Concern ◽  
Age Group ◽  
Structural Protein ◽  
The Public

Abstract Dengue is a viral disease which is serious health concern from last few decades and the infection transmitted through mosquito bite into human. This study was conducted to carry out prevalence of dengue fever in District Swabi. A total of 196 blood sample were collected from patients with age ranges (0-80 years) having dengue fever on the basis of physical symptoms from Bacha Khan Medical Complex Swabi during August to October 2017. Serological test were performed for detection of IgM, IgG and NS1 (Non structural protein antigen of virus) against dengue. Out of total 196 confirmed dengue cases the most prone gender was male 123(62%) while 73(38%) were female. Among the age groups; 21-30 years group 62 (31.6%) was found the most predominated age group. The higly affected areas in district Swabi were Topi (40.8%) followed by Main Swabi (27%), Maneri (8.2%), Marghuz (6%), Shawa Ada (5.1%), Shah Mansoor (5.1%), Gohati (4.1%), and Chota Lahore (3.6%). Therefore, the health department should take actions by educating the public about basic cleanliness of the environment. The community should be encouraged to participate in the control of such vector based diseases/infections.

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

Is there any association between body mass index and severity of dengue infection?

2021 ◽  
Author(s):  
Mohd Syis Zulkipli ◽  
Sanjay Rampal ◽  
Awang Bulgiba ◽  
Devi Peramalah ◽  
Nor'Ashikin Jamil ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Platelet Count ◽  
Dengue Fever ◽  
Body Mass ◽  
Dengue Infection ◽  
Mixed Effects ◽  
Warning Signs ◽  
Severe Dengue ◽  
Full Blood Count ◽  
Response Analysis

Abstract Background Dengue, an acute infectious disease caused by a flavivirus, is a threat to global health. There is sparse evidence exploring obesity and the development of more severe dengue cases in adults. With increasing prevalence of obesity in areas with a high risk of dengue infection, obesity may increase the burden and mortality related to dengue infection. Our study aimed to determine the association between obesity and the development of more severe dengue infection in primary healthcare settings and whether these associations were modified by dengue fever phase. Methods A cohort study was conducted among laboratory-confirmed dengue patients aged &gt;18 y in the central region of Peninsular Malaysia from May 2016 to November 2017. We collected demographic, clinical history, physical examination and laboratory examination information using a standardized form. Dengue severity (DS) was defined as either dengue with warning signs or severe dengue. Participants underwent daily follow-up, during which we recorded their vital signs, warning signs and full blood count results. Incidence of DS was modeled using mixed-effects logistic regression. Changes in platelet count and hematocrit were modeled using mixed-effects linear regression. The final multivariable models were adjusted for age, gender, ethnicity and previous dengue infection. Results A total of 173 patients were enrolled and followed up. The mean body mass index (BMI) was 37.4±13.75 kg/m2. The majority of patients were Malay (65.9%), followed by Chinese (17.3%), Indian (12.7%) and other ethnic groups (4.1%). A total of 90 patients (52.0%) were male while 36 patients (20.8%) had a previous history of dengue infection. BMI was significantly associated with DS (adjusted OR=1.17; 95% CI 1.04 to 1.34) and hematocrit (%) (aβ=0.09; 95% CI 0.01 to 0.16), but not with platelet count (x103/µL) (aβ=−0.01; 95% CI −0.84 to 0.81). In the dose response analysis, we found that as BMI increases, the odds of DS, hematocrit levels and platelet levels increase during the first phase of dengue fever. Conclusion Higher BMI and higher hematocrit levels were associated with higher odds of DS. Among those with high BMI, the development of DS was observed during phase one of dengue fever instead of during phase two. These novel results could be used by clinicians to help them risk-stratify dengue patients for closer monitoring and subsequent prevention of severe dengue complications.

scholarly journals Hematological and coagulation profile of dengue infection in age group 1 to 12 years children in a tertiary care hospital

2021 ◽  
Vol 11 (2) ◽  
pp. 341-353
Author(s):  
Suman Sarkar ◽  
Mamta Kumari ◽  
Amrita Roy ◽  
Anirban Chatterjee ◽  
Partha Pratim Pal
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Warning Signs ◽  
World Health ◽  
Infected Mosquito ◽  
Severe Dengue ◽  
Care Hospital ◽  
Coagulation Profile ◽  
D Dimer

Dengue is an arboviral infection of public health problems in tropical and sub-tropical countries transmitted to humans through the bite of an infected mosquito of the Stegomyia family. It varies in severity, ranging from influenza-like self-limiting illness to life- threatening, which if left untreated, are associated with mortality as high as 20%. Find out hematological and coagulation profile in dengue infected children aged 1 to 12 years and association of hematological and coagulation profile with dengue severity. It is an Observational Cross- sectional study done on 100 dengue patients aged 1 to 12 years during the study period from March 2019 –February 2020. Among 100 dengue fever, 85 (85%) were categorized as dengue fever (DF), 11(11%) DF with warning signs and 4 (4%) were cases of severe dengue (DHF/DSS) according to revised World Health Organisation 2009. The most common age of presentation was above 6 years and females were afflicted more with dengue fever.100% dengue patients presented with fever. Persisting vomiting, pain abdomen, hepatomegaly and hypotension indicate progression towards severe dengue. Raised Hb% and PCV, low to normal values of WBC as well as predominantly decrease in platelet was seen in severe dengue cases however, both ESR and CRP were normal. The Liver function test was deranged SGOT&#62;SGPT in almost all of the dengue patients and it was 3 to 4 times maximally in DFW and SD. PT, APTT prolongation, increased D- dimer and hypofibrinogenemia associated with the severity of dengue fever. Dengue is a common viral infection that may have serious consequences especially in children. There is clear difference in pattern of change of both haematological and biochemical parameters in non-severe dengue fever and severe dengue fever. Rising trend of Hb%, PCV, decreasing value of platelet count, raised transaminases (SGOT&#62;SGPT), elevated D- dimer, PT and APTT and hypofibrinogenemia can be used as predictor of entry into critical phase

scholarly journals Clinico-laboratory profile and outcome of dengue fever among children attending a tertiary care hospital of rural Telangana, India

2020 ◽  
Vol 7 (2) ◽  
pp. 382 ◽  
Author(s):  
V. Shekar ◽  
K. Praveen Kumar ◽  
C. Soren ◽  
K. Venkataramana Reddy ◽  
N. Dharani
Keyword(s):  
Dengue Fever ◽  
Tertiary Care Hospital ◽  
Early Recognition ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Warning Signs ◽  
Severe Dengue ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Presenting Symptoms

Background: Dengue is a self-limiting, vector-borne disease transmitted by Aedes mosquito, causing a major public health threat globally. The objective of this study is to assess the clinical profile and outcome of the dengue infection in children less than 14 years of age September 2018 to August 2019 at the Pediatric Department of S.V.S. Medical College, the tertiary care hospital in Mahabubnagar, Telanagana.Methods: Prospective study of 82 hospitalized children of <14 years with the diagnosis of dengue illness. Children with diagnosis of dengue were classified further in to two groups as per WHO guidelines, Non-severe dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (Dengue Haemorrhagic Fever and/or Dengue Shock Syndrome (DHF/DSS). A separate questionnaire form used for documenting clinical history, laboratory parameters. Haematological parameters were noted, chest x-ray, ultra-sonogram in required cases was done. Children were managed as per WHO protocol. The outcomes of the cases were mentioned as discharge, left against medical advice and death.Results: A total of 82 children with dengue were divided in to 55(67%) non severe dengue and 27(33%) severe dengue with males 56(68.2%) and females 26(31.7%). The most common age of presentation was between 6-10 years 34(41.5%). Fever 73(89%) was the most common presenting symptoms. Pleural effusion and hepatomegaly were the commonest clinical findings 28(34.1%) each, which were more among the severe dengue patients. Gall bladder edema 29(35.3%) was the most common ultra-sonogram finding. Significant elevation of transaminases (SGOP, SGPT) was seen in 39(47.5%). Severe thrombocytopenia was observed in 22(26.8%) children. Management was by administration of colloids and crystalloids.Conclusions: Dengue is a global problem. Presenting features include high grade fever, vomiting, abdominal pain, skin rash. Early recognition of symptoms and proper management can reduce the mortality.

scholarly journals Dengue Fever: Clinical Characteristics of A Tertiary Care Hospital Study

2020 ◽  
Vol 44 (1) ◽  
pp. 30-33
Author(s):  
Mohammed Rizwanul Ahsan ◽  
Manzoor Hussain ◽  
SK Azimul Hoque ◽  
Al Amin Mridha ◽  
Sabrina Makbul
Keyword(s):  
Renal Impairment ◽  
Dengue Fever ◽  
Urban Areas ◽  
Clinical Characteristics ◽  
Hepatic Dysfunction ◽  
Dengue Infection ◽  
Tertiary Care ◽  
World Health ◽  
Health Concern ◽  
Care Hospital

Background: Incidence of dengue infection has increased worldwide and has become a significant public health concern. Clinical suspicion based on the frequency of symptoms is very important for early diagnosis. Objectives: To observe the clinical characteristics of serologically confirmed hospitalized cases of dengue fever. Material and Methods: This cross-sectional study was done among admitted children with dengue infection in Dhaka Shishu (Children) Hospital from July 2018 to October 2018. The diagnosis of dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) were established according to the World Health Organization (WHO) classification criteria. Cases who were NS1 antigen and IgM dengue antibody positive included in this study. Results: Among 51 serologically confirmed dengue fever patients, mean age was 6.66 ± 3.69 years. Majority of the cases (74.5%) were less than 10 years of age, 60.8% were male, 39.2% were female, and 88.23% of patients came from urban areas. Classic DF was found in 74.5% of patients, while 25.49% of patients DHF, and 11.7% DSS. Fever was the most common (72.55%) symptom followed by headache, vomiting and myalgia. Hemorrhagic manifestations found in 21.57% of cases. The most common complications were hepatic dysfunction (47.09%) followed by renal impairment, encephalopathy, multi-organ failure, and ARDS. Conclusion: The majorities of dengue cases were from urban areas, below ten years of age and classical DF. Besides fever other common symptoms were headache, vomiting and myalgia. The most common complications were hepatic dysfunction, renal impairment and encephalopathy. Bangladesh J Child Health 2020; VOL 44 (1) :30-33

scholarly journals Socio demographic and clinical profile of dengue fever cases at a tertiary care hospital, Hyderabad, Telangana

2017 ◽  
Vol 4 (6) ◽  
pp. 2027
Author(s):  
Sunil Pal singh Chajhlana ◽  
Ramakrishna Narashimha Mahabhasyam ◽  
Maruti Sarma Mannava Varaprasada ◽  
Ravi Shankar Reddy Anukolu
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Fluid Replacement ◽  
Health Concern ◽  
Common Symptom ◽  
Care Hospital ◽  
Significant Difference

Background: Dengue fever is caused by Dengue Virus, belonging to the family Flaviviridae, transmitted by Aedes aegypti and Aedes albopictus mosquito. There are four distinct dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). This viral disease of humans has become a major international public health concern in recent years. Differential diagnosis based on symptoms is challenging due to dengue’s non-specific symptoms such as fever, aches and fatigue that are often overlap with other endemic infections. Dengue-associated mortality can be reduced from 20–30% in severe cases to less than 1% with appropriate fluid replacement and supportive care, which is greatly facilitated by early diagnosis. Aim and objective: To study the demographic factors and clinical features of dengue fever cases in urban areas of Hyderabad.Methods: The present study was conducted by Department of Community Medicine in collaboration with Department of Microbiology, Kamineni academy of medical sciences and research center, Hyderabad. Study subjects: “Probable” dengue cases admitted in the various departments during July –December 2016. Data collection was done using a structured questionnaire. Serum samples were tested for NS1 antigen, IgM, IgG antibodies by rapid visual immunochromatography.Results: Out of 137 samples of clinically suspected dengue cases, 119 were found positive for dengue infection. Fever was the most common symptom found in all the patients Majority of cases, 56.3% were males. Thrombocytopenia, leucopenia and bleeding manifestation were found in 84.0 %, 84.8% and 58.8% patients respectively.Conclusions: Fever was the most common symptom found in all the patients. Majority of cases showed thrombocytopenia. Significant difference was found in the clinical signs and symptoms like fever, myalgia, hypotension, thrombocytopenia and leucopenia in dengue cases than controls. 

scholarly journals Study of incidence, manifestations and complications of dengue fever

2018 ◽  
Vol 5 (1) ◽  
pp. 137
Author(s):  
Jahnavi K. ◽  
Srinivasulu T.
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Simple Random Sampling ◽  
Study Data ◽  
World Health ◽  
Care Hospital

Background: Dengue is endemic in India and epidemics are common. Due to poor availability of resources, there is increased morbidity and mortality related to dengue. The objective of the research to study the incidence, manifestations and complications of dengue fever.Methods: Patients admitted in medicine wards of a tertiary care hospital during the study period of two years with the history of fever with other nonspecific symptoms were included in the present study. Data was collected in a pre-tested proforma by meeting objectives of the present study. 100 patients who fulfilled World Health Organization criteria for dengue fever were selected by simple random sampling method.Results: In 75 patients the platelet count was above 150000cell/cumm. Most of them had dengue fever. 12 patients showed platelet count between 20000-100000cells/cumm. and among them 10 were DHF and 2 were simple dengue infection. Five patients showed platelet count less than 20000cells/cumm. and among them 2 were DHF and 3 were DSS. Most of the bleeding skin manifestations were seen when platelet count was below 50000cells/cumm. Mucosal bleeding was observed when the platelet count was below 30000cells/cumm. Abnormal coagulation profile was noted in 18% of the patients and 6% patients were in acute renal failure. Mortality was 0% in dengue fever, 44% in DHF and 100% in DSS.Conclusions: Platelet count was directly related to the number of complications. Dengue shock syndrome and dengue hemorrhagic fever was associated with increased mortality.

scholarly journals A study to determine the severity based outcome of pediatric patients with dengue spectrum disorders in a tertiary care hospital

2019 ◽  
Vol 7 (1) ◽  
pp. 154
Author(s):  
Vijaysuryakiran K. M. ◽  
Mounesh Pattar ◽  
Sanjay Paida
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Warning Signs ◽  
Severe Dengue ◽  
Warning Sign ◽  
High Morbidity ◽  
Care Hospital ◽  
Increased Risk ◽  
Spectrum Disorders

Background: Dengue Fever (DF) has become a major global public health problem. The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. Dengue infection ranges from mild illness to a severe form of haemorrhagic fever and shock syndrome which may prove fatal. Objective of the study was to determine severity-based outcome in children with dengue spectrum disorder in a tertiary care centre in Mumbai.Methods: It was a prospective, non-interventional, observational, surveillance study conducted over 14 months (from September 2016 till October 2017). Children aged <18 years admitted to Nanavati Super Specialty Hospital, Mumbai diagnosed with dengue spectrum disorders according to WHO 2009 classification with clinical features and laboratory investigation confirming dengue were enrolled as study participants.Results: Out of 127 patients, 57(44.9%) were females and 70(55.1%) were males. 81(63.8%) were ward patients, 46(36.2%) required PICU admission. 17(13.4%) patients had dengue with warning signs, 100(78.7%) had dengue without warning signs and 10(7.9%) had severe dengue according to WHO 2009 case classification of dengue. 122(96.1%) were discharged home, 4(3.1%) died of dengue and dengue related complications all four deaths occurred in children with severe dengue.Conclusions: This study showed that commonest inpatient admission category among children with dengue according to WHO 2009 classification was dengue without warning signs Overall mortality in patients with dengue fever without warning sign as well those with warning sign remains very low. Children presenting with severe dengue associated with either organ failure or refractory shock are at increased risk of mortality.

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