scholarly journals Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication

2021 ◽  
Author(s):  
Zanna Fiodorenko-Dumas ◽  
Ilias Dumas ◽  
Maciej Rabczynski ◽  
Rafał Małecki ◽  
Rajmund Adamiec ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Vascular Complications ◽  
Intima Media Thickness ◽  
Vascular Complication ◽  
Diabetic Patients ◽  
Symmetric Dimethylarginine ◽  
Media Thickness ◽  
Group A ◽  
Group B

Introduction. Patients with type 2 diabetes represent 50% of all sudden cardiac deaths. Disseminated arteriosclerotic lesions are the cause of vascular incidents that cause permanent disability resulting from lower limb amputations. Objectives. Our study was designed to investigate the relationship between asymmetrical dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) plasma concentration and intima–media thickness (IMT) in subjects with diabetes mellitus without vascular complications (group A) and a group of diabetic patients diagnosed with diabetes micro- and macroangiopathy (group B). Patients and Method. The experimental groups included 42 diabetic patients. Group A – 22 patients (9 W and 13 M), free from vascular complications (mean age 55.83±7.37 years), group B – 20 patients (6 W, 14 M) with accompanying micro- and macropathic changes (mean age 63.80±8.79 years). Group C (n=22), the control group, consisted of healthy volunteers (12 W and 10 M), between the ages of 40 to 60 (mean age 51.16±6.39), selected in reference to the age and sex of the research group. The carotid artery intima-media complex thickness (IMT) was evaluated with the use of a duplex ultrasound. Conclusions. There was no correlation between ADMA and the maximal or mean intima–media thickness (IMT) of the common carotid artery (CCA) and internal carotid artery (ICA). We demonstrated a correlation between symmetric dimethylarginine (SDMA) concentration and CCA IMT. The results suggest that ICA IMT may serve as a marker of vascular complication among patients with diabetes.

scholarly journals Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

Diabetes Care ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 1308-1312 ◽  
Author(s):  
N. Mitsuhashi ◽  
T. Onuma ◽  
S. Kubo ◽  
N. Takayanagi ◽  
M. Honda ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Artery Disease ◽  
Type 2 Diabetic

Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients

2006 ◽  
Vol 65 (5) ◽  
pp. 593-597 ◽  
Author(s):  
Giovanni Targher ◽  
Lorenzo Bertolini ◽  
Roberto Padovani ◽  
Luciano Zenari ◽  
Luca Scala ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Type 2 Diabetic

Abstract T P170: Carotid Artery Intima-Media Thickness and Ankle-Brachial Index are Strong Predictors of Complicated Aortic Arch Plaque in Acute Cerebral Embolism Patients

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Kazuyoshi Kaneko ◽  
Hiroki Saito ◽  
Yuichi Tsunoda ◽  
Shigeo Sugawara ◽  
Masahiro Akasaka ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Aortic Arch ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Cerebral Embolism ◽  
Media Thickness ◽  
Group A ◽  
Group B

Background: Complicated aortic arch plaque (CAP) detected by transesophageal echocardiography (TEE) provides prognostic information regarding cerebrovascular disease risk. Coexistence of peripheral atherosclerotic disease worsens the prognosis in ischemic stroke patients. Methods: We examined TEE, carotid artery intima-media thickness (CIMT, calculated from carotid echograms), and ankle-brachial index (ABI, calculated from ankle/brachial blood pressure ratios) in 100 consecutive cerebral embolism patients within 2 weeks of onset of symptoms. CAP was defined as atherosclerotic plaque (≥4mm) or presence of ulcerated plaque assessed by TEE. Patients were classified into those with CAP (n=36, Group A) or without CAP (n=64, Group B). Results: Comparing patients in the two groups, significantly higher values were seen in Group A for age (69±8 vs. 63±11 years, p<0.01), prevalence of hypertension (75% vs. 50%, p<0.05) and ischemic heart disease (19% vs. 3%, p<0.01), and CIMT (1.9±0.8 vs. 1.2±0.5 mm, p<0.0001). Significantly lower values were seen in Group B for ABI (0.93±0.22 vs. 1.11±0.11, p<0.0001). Defining arteriosclerosis obliterans (ASO) as ABI <0.9 and CIMT thickening as CIMT ≥1.1mm, CAP was predicted by ASO with 39% sensitivity and 97% specificity, and by CIMT thickening with 78% sensitivity and 48% specificity. Combined ASO and CIMT thickening predicted CAP with 83% sensitivity and 81% positive predictive value, and with 97% specificity and 83% negative predictive value in all of the subjects. Furthermore, aortic arch intima-media thickness was significantly correlated with CIMT and ABI (r=0.441, p<0.0001 and r=-0.384, p<0.0001, respectively). Conclusions: For non-invasive evaluation of patients with acute cerebral embolism, the combination of both ABI and CIMT predicts CAP more strongly than either ABI or CIMT considered alone, with higher figures for sensitivity, specificity, and positive and negative predictive value.

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