scholarly journals Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

2016 ◽  
Vol 63 (3) ◽  
Author(s):  
Jolanta Kiewisz ◽  
Monika M. Kaczmarek ◽  
Anna Pawlowska ◽  
Zbigniew Kmiec ◽  
Tomasz Stompor
Keyword(s):  
Cardiovascular Diseases ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Blood Cells ◽  
Current Knowledge ◽  
Kidney Diseases ◽  
Small Population ◽  
Endothelial Progenitor ◽  
Abundant Evidence ◽  
Macrophage Lineage

Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm3), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.

Endothelial progenitor cells and hypertension: current concepts and future implications

2016 ◽  
Vol 130 (22) ◽  
pp. 2029-2042 ◽  
Author(s):  
Shengyuan Luo ◽  
Wenhao Xia ◽  
Cong Chen ◽  
Eric A. Robinson ◽  
Jun Tao
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Current Knowledge ◽  
Circulatory System ◽  
Essential Element ◽  
Future Research ◽  
Chronic Hypertension ◽  
Vascular Endothelial ◽  
Endothelial Progenitor ◽  
Endothelial Integrity

The discovery of endothelial progenitor cells (EPCs), a group of cells that play important roles in angiogenesis and the maintenance of vascular endothelial integrity, has led to considerable improvements in our understanding of the circulatory system and the regulatory mechanisms of vascular homoeostasis. Despite lingering disputes over where EPCs actually originate and how they facilitate angiogenesis, extensive research in the past decade has brought about significant advancements in this field of research, establishing EPCs as an essential element in the pathogenesis of various diseases. EPC and hypertensive disorders, especially essential hypertension (EH, also known as primary hypertension), represent one of the most appealing branches in this area of research. Chronic hypertension remains a major threat to public health, and the exact pathologic mechanisms of EH have never been fully elucidated. Is there a relationship between EPC and hypertension? If so, what is the nature of such relationship–is it mediated by blood pressure alterations, or other factors that lie in between? How can our current knowledge about EPCs be utilized to advance the prevention and clinical management of hypertension? In this review, we set out to answer these questions by summarizing the current concepts about EPC pathophysiology in the context of hypertension, while attempting to point out directions for future research on this subject.

Vasculogenesis and Its Cellular Therapeutic Applications

2016 ◽  
Vol 203 (3) ◽  
pp. 141-152 ◽  
Author(s):  
Anna Ratajska ◽  
Ewa Jankowska-Steifer ◽  
Elżbieta Czarnowska ◽  
Radosław Olkowski ◽  
Grzegorz Gula ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
De Novo ◽  
Current Knowledge ◽  
Endothelial Progenitor ◽  
Therapeutic Applications ◽  
Adult Tissues ◽  
Embryonic Life

Vasculogenesis was originally defined by Risau in 1997 [Nature 386: 671-674] as the de novo formation of vessels from endothelial progenitor cells (EPCs), so-called angioblasts. Initially, this process was believed to be related only to embryonic life; however, further studies reported vasculogenesis to occur also in adult tissues. This overview presents the current knowledge about the origin, differentiation and significance of EPCs that have been observed in various diseases, tumors, and reparative processes. We also summarize the knowledge of how to activate these cells for therapeutic purposes and the outcomes of the therapies.

Therapeutic Potential of Endothelial Progenitor Cells for Cardiovascular Diseases

2006 ◽  
Vol 4 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Lijing Jia ◽  
Masafumi Takahashi ◽  
Toru Yoshioka ◽  
Hajime Morimoto ◽  
Hirohiko Ise ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Therapeutic Potential ◽  
Endothelial Progenitor

scholarly journals Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Carmela R. Balistreri ◽  
Silvio Buffa ◽  
Calogera Pisano ◽  
Domenico Lio ◽  
Giovanni Ruvolo ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Cell Biology ◽  
Therapeutic Agents ◽  
Stem Cell Biology ◽  
Endothelial Progenitor ◽  
The Real ◽  
Large Heterogeneity ◽  
Advanced Knowledge

Advanced knowledge in the field of stem cell biology and their ability to provide a cue for counteracting several diseases are leading numerous researchers to focus their attention on “regenerative medicine” as possible solutions for cardiovascular diseases (CVDs). However, the lack of consistent evidence in this arena has hampered the clinical application. The same condition affects the research on endothelial progenitor cells (EPCs), creating more confusion than comprehension. In this review, this aspect is discussed with particular emphasis. In particular, we describe biology and physiology of EPCs, outline their clinical relevance as both new predictive, diagnostic, and prognostic CVD biomarkers and therapeutic agents, discuss advantages, disadvantages, and conflicting data about their use as possible solutions for vascular impairment and clinical applications, and finally underline a very crucial aspect of EPCs “characterization and definition,” which seems to be the real cause of large heterogeneity existing in literature data on this topic.

Sign in / Sign up

Export Citation Format

Share Document