scholarly journals Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans.

2013 ◽  
Vol 60 (3) ◽  
Author(s):  
Jarosław Walkowiak ◽  
Joanna Bajerska ◽  
Angelika Kargulewicz ◽  
Aleksandra Lisowska ◽  
Gwidon Siedlerski ◽  
...  

Green tea is known worldwide for its high content of polyphenolic compounds and multifactorial beneficial effects on human health. The role of green tea as an inhibitor of lipid hydrolysis is widely discussed. The aim of the study was to assess the influence of green tea extract on lipid digestion and absorption. The study comprised 32 healthy volunteers aged 23 to 30 years with normal exocrine pancreatic function. In all subjects (13)C-labelled mixed triglyceride breath test was performed twice with and without green tea extract ingestion. Cumulative percentage dose recovery was considered to reflect digestion and absorption of lipids. Values are expressed as medians and 1st-3rd quartile distribution. In all subjects, cumulative percentage dose recovery values were normal in a placebo test (36.8% ). These results were significantly higher (p=0.021) than those obtained in green tea extract test (28.8% ). Results of six tests with GTE were abnormal. Single dose of green tea extract taken with a test meal decreases lipid digestion and absorption in humans.

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 195 ◽  
Author(s):  
Xi Fang ◽  
Michael Azain ◽  
Kristi Crowe-White ◽  
Jennifer Mumaw ◽  
Janet A. Grimes ◽  
...  

Green tea and its catechins have been shown to ameliorate high fat diet-induced oxidative stress and hyperlipidemia. However, low bioavailability of catechins limits their therapeutic potential. Lemon juice (LJ) has been suggested to enhance the bioavailability of catechins in vitro. This study investigated the antioxidative and hypolipidemic efficacy of a single dose of green tea extract (GTE) or GTE plus LJ (GTE + LJ) in high-fat diet fed pigs. Sixteen pigs ingested a single dose of GTE (190 mg/kg/day) or GTE + LJ (0.75 mL/kg/day) mixed with low-fat (LF; 5% fat) or high-fat (HF; 22% fat) diets and blood samples were collected for 24 h. Plasma catechin level peaked at two hours, and gradually returned to baseline after six hours following the intake. The addition of LJ significantly increased plasma catechin level. The diet containing GTE did not lower plasma cholesterol and triacylglycerol (TG) concentrations, superoxide dismutase (SOD) and catalase activity, or malondialdehyde concentration in 24 h in HF-fed pigs. Addition of a single dose of LJ, however, significantly decreased plasma TG level in LF groups but did not cause further changes on any other markers compared to the GTE alone. Our findings indicate limited effect of a single meal containing GTE on plasma antioxidant enzymes, lipid profile, and lipid peroxidation in pigs and no significant synergistic/additive action of adding LJ to GTE within 24 h in pigs. A study with a longer treatment period is warranted to further understand the potential role of GTE in reducing HF diet-induced oxidative stress and the possible synergistic role of LJ.


2020 ◽  
Vol 21 (1) ◽  
pp. 31-35
Author(s):  
Basma El-Desoky ◽  
Shaimaa El-Sayed ◽  
El-Said El-Said

Objective: Investigating the effect of green tea extract (GTE) on the testicular damage induced by cadmium chloride CdCl2 in male rats. Design: Randomized controlled study. Animals: 40 male Wistar rats. Procedures: Rats were randomly divided into four groups: A) control group (each rat daily received pellet diet); B) GTE group each rat daily received pellet diet as well as 3 ml of 1.5 % w/v GTE, C) CdCl2 group each rat was I/P injected a single dose of 1 mg/kg CdCl2, then daily received pellet diet, and D) CdCl2+GTE group each rat was I/P injected a single dose of 1 mg/kg CdCl2 then daily received pellet diet as well as 3 ml of 1.5 % w/v GTE. After 30 days, blood samples were collected for hormonal assays (testosterone, FSH, and LH). In addition, both testes were collected; one of them was used for quantification of 17-beta hydroxysteroid dehydrogenase III (17β-HSDIII) gene expression using a real-time PCR. The other testis was used for determination of catalase and reduced glutathione; GSH, Nitric oxide (NO) and malondialdehyde (MDA) levels. Results: CdCl2 decreased serum testosterone levels and its synthesis pathway (17β-HSDIII testicular gene expression). While antioxidants catalase and GSH were reduced, oxidants MDA were enriched in the testes of CdCl2-poisoned rats. This CdCl2-promoted testicular dysfunction was corrected via the administration of GTE to male rats. Conclusion and clinical relevance: GTE could be used as a remedy for protecting against CdCl2-induced testicular damage in male rats.


2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Klaudia Lochocka ◽  
Joanna Bajerska ◽  
Aleksandra Glapa ◽  
Ewa Fidler-Witon ◽  
Jan K. Nowak ◽  
...  

Phytomedicine ◽  
2021 ◽  
pp. 153754
Author(s):  
Mahdieh Sadat Mohsenzadeh ◽  
Bibi Marjan Razavi ◽  
Mohsen Imenshahidi ◽  
Seyed Abbas Tabatabaee Yazdi ◽  
Seyed Ahmad Mohajeri ◽  
...  

2009 ◽  
Vol 44 (3) ◽  
pp. 239-246 ◽  
Author(s):  
Kazuo Nakamoto ◽  
Fusako Takayama ◽  
Mitsumasa Mankura ◽  
Yuki Hidaka ◽  
Toru Egashira ◽  
...  

2013 ◽  
Vol 122 (4) ◽  
pp. 270-277
Author(s):  
Sweety Nasrin ◽  
Ayaka Osano ◽  
Yoshihiko Ito ◽  
Shizuo Yamada

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