scholarly journals Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance.

2011 ◽  
Vol 58 (2) ◽  
Author(s):  
Riyadh Saif-Ali ◽  
Roslan Harun ◽  
S Al-Jassabi ◽  
Wan Zurinah Wan Ngah
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Nuclear Factor ◽  
Nucleotide Polymorphisms ◽  
Hepatocyte Nuclear Factor ◽  
Coding Region ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Hnf4 Alpha

This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.

scholarly journals A Novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4  Gene (HNF4A) Associates With Late-Onset Diabetes

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1869-1873 ◽  
Author(s):  
J. Ek ◽  
S. P. Hansen ◽  
M. Lajer ◽  
C. Nicot ◽  
T. W. Boesgaard ◽  
...  
Keyword(s):  
Late Onset ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Onset Diabetes ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4

Association of Hepatocyte Nuclear Factor 4 Alpha Polymorphisms with Type 2 Diabetes With or Without Metabolic Syndrome in Malaysia

2011 ◽  
Vol 50 (3-4) ◽  
pp. 298-308 ◽  
Author(s):  
Riyadh Saif-Ali ◽  
Roslan Harun ◽  
Nor Azmi Kamaruddin ◽  
Saad Al-Jassabi ◽  
Wan Zurinah Wan Ngah
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4

scholarly journals Hepatocyte Nuclear Factor-4  P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

Diabetes ◽  
2006 ◽  
Vol 55 (5) ◽  
pp. 1260-1264 ◽  
Author(s):  
K. Hara ◽  
M. Horikoshi ◽  
H. Kitazato ◽  
C. Ito ◽  
M. Noda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Population ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Promoter Haplotypes

scholarly journals Common Variants of the Hepatocyte Nuclear Factor-4  P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Diabetes ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 3002-3006 ◽  
Author(s):  
M. N. Weedon ◽  
K. R. Owen ◽  
B. Shields ◽  
G. Hitman ◽  
M. Walker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Common Variants ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4

scholarly journals Hepatocyte Nuclear Factor 4 Alpha Polymorphisms and the Metabolic Syndrome in French-Canadian Youth

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117238 ◽  
Author(s):  
Valérie Marcil ◽  
Devendra Amre ◽  
Ernest G. Seidman ◽  
François Boudreau ◽  
Fernand P. Gendron ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
French Canadian ◽  
Canadian Youth ◽  
The Metabolic Syndrome ◽  
Hepatocyte Nuclear Factor 4

scholarly journals Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.

1996 ◽  
Vol 16 (3) ◽  
pp. 925-931 ◽  
Author(s):  
T Drewes ◽  
S Senkel ◽  
B Holewa ◽  
G U Ryffel
Keyword(s):  
Splice Variant ◽  
Binding Activity ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Dna Binding Activity ◽  
Nuclear Extracts ◽  
Transactivation Potential ◽  
Genes Encoding ◽  
Hepatocyte Nuclear Factor 4 ◽  
Hnf4 Alpha

Hepatocyte nuclear factor 4 (HNF4) was first identified as a DNA binding activity in rat liver nuclear extracts. Protein purification had then led to the cDNA cloning of rat HNF4, which was found to be an orphan member of the nuclear receptor superfamily. Binding sites for this factor were identified in many tissue-specifically expressed genes, and the protein was found to be essential for early embryonic development in the mouse. We have now isolated cDNAs encoding the human homolog of the rat and mouse HNF4 splice variant HNF4 alpha 2, as well as a previously unknown splice variant of this protein, which we called HNF alpha 4. More importantly, we also cloned a novel HNF4 subtype (HNF4 gamma) derived from a different gene and showed that the genes encoding HNF 4 alpha and HNF4 gamma are located on human chromosomes 20 and 8, respectively. Northern (RNA) blot analysis revealed that HNF4 GAMMA is expressed in the kidney, pancreas, small intestine, testis, and colon but not in the liver, while HNF4 alpha RNA was found in all of these tissues. By cotransfection experiments in C2 and HeLa cells, we showed that HNF4 gamma is significantly less active than HNF4 alpha 2 and that the novel HNF4 alpha splice variant HNF4 alpha 4 has no detectable transactivation potential. Therefore, the differential expression of distinct HNF4 proteins may play a key role in the differential transcriptional regulation of HNF4-dependent genes.

Immunocytochemical study for hepatocyte nuclear factor 4^|^alpha; (HNF4^|^alpha;) in body cavity fluids

2014 ◽  
Vol 53 (3) ◽  
pp. 176-181
Author(s):  
Mika SUGAI ◽  
Makoto NAITO ◽  
Kanae TAKAHASHI ◽  
Chikashi IKEGAME ◽  
Chiaki SAKASHITA ◽  
...  
Keyword(s):  
Body Cavity ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Immunocytochemical Study ◽  
Hepatocyte Nuclear Factor 4 ◽  
Hnf4 Alpha

Hepatocyte Nuclear Factor 4-α (HNF4α) controls the insulin resistance-induced pancreatic β-cell mass expansion

Life Sciences ◽  
2021 ◽  
pp. 120213
Author(s):  
Robson Barth ◽  
Carolina Ruoso ◽  
Sandra Mara Ferreira ◽  
Franciele Caroline de Ramos ◽  
Fernanda Barbosa Lima ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Mass ◽  
Nuclear Factor ◽  
Pancreatic Β Cell ◽  
Hepatocyte Nuclear Factor ◽  
Β Cell ◽  
Hepatocyte Nuclear Factor 4 ◽  
Mass Expansion
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