scholarly journals Haemoglobin scavenger receptor: function in relation to disease.

2006 ◽  
Vol 53 (2) ◽  
pp. 257-268 ◽  
Author(s):  
Jolanta Zuwała-Jagiełło
Keyword(s):  
Transplant Rejection ◽  
Scavenger Receptor ◽  
Interleukin 10 ◽  
Diagnostic Tools ◽  
Soluble Cd163 ◽  
Disease States ◽  
Promising Target ◽  
Inflammatory Processes ◽  
Haem Oxygenase ◽  
New Treatment

Highly efficient systems remove the toxic and proinflammatory haemoglobin from the circulation and local sites of tissue damage. Macrophages are major haemoglobin-clearing cells; CD163 was recently recognized as the specific haemoglobin scavenger receptor (HbSR). It is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection and inflammation. Haemoglobin functions as a double-edged sword. In moderate quantities and bound to haptoglobin, it forms a ligand for haemoglobin scavenger receptor CD163/HbSR, but when unleashed in large amounts, it can become toxic by mediating oxidative stress and inflammation. CD163/HbSR plays a crucial role in the control of inflammatory processes, probably in part through its effects on both ferritin induction and subsequent induction of antiinflammatory pathways through interleukin-10 and haem oxygenase. Besides the observation that the haemoglobin scavenger receptor provides a promising target for new treatment possibilities, it offers a novel view on the aetiology of diverse physiological as well as pathophysiological processes. In addition, monocyte CD163/HbSR and soluble CD163/HbSR are potential diagnostic tools in a variety of disease states, such as inflammation, atherosclerosis, transplant rejection, and carcinoma.

Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10

Blood ◽  
2000 ◽  
Vol 96 (7) ◽  
pp. 2568-2573
Author(s):  
Laszlo Cervenak ◽  
Lucia Morbidelli ◽  
Daria Donati ◽  
Sandra Donnini ◽  
Taku Kambayashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transplant Rejection ◽  
Interleukin 10 ◽  
Vascular Endothelial ◽  
Direct Role ◽  
Lymphoid Malignancies ◽  
Disease States ◽  
Endothelial Growth Factor

Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10–transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165–induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2–induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.

Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10

Blood ◽  
2000 ◽  
Vol 96 (7) ◽  
pp. 2568-2573 ◽  
Author(s):  
Laszlo Cervenak ◽  
Lucia Morbidelli ◽  
Daria Donati ◽  
Sandra Donnini ◽  
Taku Kambayashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transplant Rejection ◽  
Interleukin 10 ◽  
Vascular Endothelial ◽  
Direct Role ◽  
Lymphoid Malignancies ◽  
Disease States ◽  
Endothelial Growth Factor

Abstract Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10–transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165–induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2–induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.

scholarly journals Inflammatory Mechanisms Underlying Nonalcoholic Steatohepatitis and the Transition to Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 730
Author(s):  
Moritz Peiseler ◽  
Frank Tacke
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Disease Progression ◽  
Immune Cells ◽  
Nonalcoholic Steatohepatitis ◽  
Adaptive Immune System ◽  
Nonalcoholic Fatty Liver ◽  
Inflammatory Processes ◽  
New Treatment ◽  
End Stage

Nonalcoholic fatty liver disease (NAFLD) is a rising chronic liver disease and comprises a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) to end-stage cirrhosis and risk of hepatocellular carcinoma (HCC). The pathogenesis of NAFLD is multifactorial, but inflammation is considered the key element of disease progression. The liver harbors an abundance of resident immune cells, that in concert with recruited immune cells, orchestrate steatohepatitis. While inflammatory processes drive fibrosis and disease progression in NASH, fueling the ground for HCC development, immunity also exerts antitumor activities. Furthermore, immunotherapy is a promising new treatment of HCC, warranting a more detailed understanding of inflammatory mechanisms underlying the progression of NASH and transition to HCC. Novel methodologies such as single-cell sequencing, genetic fate mapping, and intravital microscopy have unraveled complex mechanisms behind immune-mediated liver injury. In this review, we highlight some of the emerging paradigms, including macrophage heterogeneity, contributions of nonclassical immune cells, the role of the adaptive immune system, interorgan crosstalk with adipose tissue and gut microbiota. Furthermore, we summarize recent advances in preclinical and clinical studies aimed at modulating the inflammatory cascade and discuss how these novel therapeutic avenues may help in preventing or combating NAFLD-associated HCC.

scholarly journals Assessment of Aspergillus-Specific T Cells for Diagnosis of Invasive Aspergillosis in a Leukemic Child with Liver Lesions Mimicking Hepatosplenic Candidiasis

2008 ◽  
Vol 15 (10) ◽  
pp. 1625-1628 ◽  
Author(s):  
Leonardo Potenza ◽  
Patrizia Barozzi ◽  
Giulio Rossi ◽  
Giovanni Palazzi ◽  
Daniela Vallerini ◽  
...  
Keyword(s):  
T Cells ◽  
Invasive Aspergillosis ◽  
Elispot Assay ◽  
Interleukin 10 ◽  
Diagnostic Tools ◽  
Liver Lesions ◽  
Negative Results ◽  
Hepatosplenic Candidiasis ◽  
Ifn Γ ◽  
Leukemic Child

ABSTRACT A child with acute myeloid leukemia presented with multiple liver lesions mimicking hepatosplenic candidiasis during the neutropenic phase following the induction chemotherapy. All the available diagnostic tools showed repeatedly negative results, including galactomannan. An enzyme-linked immunospot (ELISPOT) assay showed a high number of Aspergillus-specific T cells producing interleukin-10 [TH2(IL-10)] and a low number of Aspergillus-specific T cells producing gamma interferon [TH1(IFN-γ)], revealing invasive aspergillosis (IA) before the confirmatory biopsy. A progressive skewing from the predominance of TH2(IL-10) to a predominance of TH1(IFN-γ) was observed close to the complete resolution of the infection and foreshadowed the outcome. The ELISPOT assay holds promise for diagnosing pediatric IA.

scholarly journals Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10–producing suppressive CD4+ T cells

2012 ◽  
Vol 209 (1) ◽  
pp. 109-121 ◽  
Author(s):  
Dapeng Li ◽  
Gabrielle Romain ◽  
Anne-Laure Flamar ◽  
Dorothée Duluc ◽  
Melissa Dullaers ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Oxidized Ldl ◽  
Scavenger Receptor ◽  
Ldl Receptor ◽  
Interleukin 10 ◽  
Protein Antigens ◽  
Host Immune Responses

Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4+ T cells. DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known scavenger receptor. Here, we report that targeting antigens to human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific ICAM-3–grabbing nonintegrin favors the generation of antigen-specific suppressive CD4+ T cells that produce interleukin 10 (IL-10). These findings apply to both self- and foreign antigens, as well as memory and naive CD4+ T cells. The generation of such IL-10–producing CD4+ T cells requires p38/extracellular signal-regulated kinase phosphorylation and IL-10 induction in DCs. We further demonstrate that immunization of nonhuman primates with antigens fused to anti–DC-ASGPR monoclonal antibody generates antigen-specific CD4+ T cells that produce IL-10 in vivo. This study provides a new strategy for the establishment of antigen-specific IL-10–producing suppressive T cells in vivo by targeting whole protein antigens to DCs via DC-ASGPR.

scholarly journals Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Akiko Okamoto ◽  
Keishi Fujio ◽  
Tomohisa Okamura ◽  
Kazuhiko Yamamoto
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Organ Damage ◽  
Interleukin 10 ◽  
Peripheral Tolerance ◽  
Systemic Lupus ◽  
Autoantibody Production ◽  
Inflammatory Processes ◽  
Complex Deposition

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage. An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both innate and adoptive immune responses, will enable the development of novel therapies for SLE. Regulatory T cells (Treg) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4+CD25+Treg, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been intensively studied because their deficiency abrogates self-tolerance and causes autoimmune disease. Moreover, regulatory cytokines such as interleukin-10 (IL-10) also play a central role in controlling inflammatory processes. This paper focuses on Tregs and Treg-associated cytokines which might regulate the pathogenesis of SLE and, hence, have clinical applications.

Growth Hormone Secretagogues as Diagnostic Tools in Disease States

Endocrine ◽  
2001 ◽  
Vol 14 (1) ◽  
pp. 095-099 ◽  
Author(s):  
Roberto Baldelli ◽  
Xose L Otero ◽  
Jesus P Camiña ◽  
Oreste Gualillo ◽  
Vera Popovic ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Diagnostic Tools ◽  
Growth Hormone Secretagogues ◽  
Disease States

scholarly journals Soluble CD163 Is a Predictor of Mortality in Patients With Decompensated Cirrhosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Yue Zhang ◽  
Chenkai Huang ◽  
Yuan Nie ◽  
Qi Liu ◽  
Nanxi Xiao ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Scoring System ◽  
Scavenger Receptor ◽  
Scoring Systems ◽  
Predictive Performance ◽  
Decompensated Cirrhosis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Soluble Cd163 ◽  
End Stage ◽  
New Scoring

Background: Soluble CD163 (sCD163) is a scavenger receptor membrane protein expressed almost exclusively on Kupffer cells and other macrophages. It was found to be associated with the severity of liver cirrhosis. The aim of the present study was to determine whether the novel biomarker sCD163 predicts outcomes in patients with decompensated cirrhosis.Materials and Methods: A single-center, observational, prospective study with 345 decompensated cirrhosis patients was conducted in the Gastroenterology Department between January 2017 and December 2020. Their plasma samples were tested by enzyme-linked immunosorbent assay (ELISA) for sCD163 within 24 hours of admission. These patients were followed up at 28 days, 3 months and 6 months. The independent risk factors were identified with uni- and multivariate logistic regression analyses. We evaluated the predictive performance of the new scoring system (including sCD163) and the original scoring system.Results: The sCD163 level was significantly higher in non-surviving patients than in surviving patients. Positive associations were found between sCD163 levels and the Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD) and albumin-bilirubin (ALBI) scores. Logistic regression confirmed that sCD163 was an independent risk factor for 28-day, 3-month, and 6-month mortality. The areas under the receiver operating characteristic curves (AUROCs) of the use of sCD163 for the prediction of 28-day, 3-month, and 6-month mortality were relatively higher (AUROCs: 0.856; 0.823 and 0.811, respectively). The AUROCs of the new scores obtained by adding sCD163 to the original scoring systems (CTP + sCD163, MELD + sCD163 and ALBI + sCD163) showed that the new scoring systems had better predictive performance than the original scoring systems at all time points (P < 0.001).Conclusion: sCD163 is a prognostic predictor of short-term and long-term outcomes in decompensated cirrhosis patients. Accordingly, the addition of sCD163 to the original clinical scoring systems improved their prognostic performance.

scholarly journals Assessment of Serum Interleukin-19 Level in Patients with Diabetic Nephropathy

2021 ◽  
pp. 15-25
Author(s):  
Mariam A. Atiia ◽  
Yasser M. Hafez ◽  
Maaly M. Mabrouk ◽  
Medhat A. Ghazy
Keyword(s):  
Diabetic Nephropathy ◽  
Interleukin 10 ◽  
Cross Sectional Study ◽  
Control Group ◽  
University Hospitals ◽  
Cross Sectional ◽  
Angiogenic Potential ◽  
Reactive Protein ◽  
Inflammatory Processes ◽  
Healthy Control

Background: Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10 (IL-10) family. IL-19 has indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to assess the level of serum interleukin-19 (IL-19) in patients with diabetic nephropathy (DN). Our Study Aimed to assess the level of serum IL-19 in patients with diabetic nephropathy. Methods: In this cross-sectional study, we tested 90 subjects; 30 healthy control and 60 diabetic nephropathy patients recruited from outpatient clinics and wards of Internal Medicine department, Tanta university hospitals, Egypt. Patients were subdivided into 3subgroup according to the urinary albumin creatinine ratio (ACR). Results: The serum IL-19 levels in DN patients were significantly higher than the control group. The mean serum IL-19 level was 15.45±4.34 Pg/ml, 32.66±8.05 Pg/ml, 56.03±7.89 Pg/ml and 71.41±12.37 Pg/ml dL for control, normoalbuminuria group, microalbuminuria group and macroalbuminuria group respectively. Conclusions: Serum IL-19 level was significantly elevated in patients with diabetic nephropathy and was associated with the marker of inflammation CRP (C -reactive protein). So

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