scholarly journals Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.

2002 ◽  
Vol 49 (1) ◽  
pp. 269-272 ◽  
Author(s):  
Daniel Gackowski ◽  
Marcin Kruszewsk ◽  
Zbigniew Banaszkiewicz ◽  
Arkadiusz Jawien ◽  
Ryszard Olinski
Keyword(s):  
Binding Capacity ◽  
Transferrin Saturation ◽  
Control Group ◽  
Iron Level ◽  
Iron Availability ◽  
Serum Iron Level ◽  
Labile Iron Pool ◽  
Labile Iron ◽  
Iron Pool ◽  
Iron Binding Capacity

Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.

scholarly journals The U-shaped association of serum iron level with COVID-19 severity: Is iron a potential therapeutic target?

2021 ◽  
Author(s):  
Kentaro Tojo ◽  
Yoh Sugawara ◽  
Yasufumi Oi ◽  
Fumihiro Ogawa ◽  
Takuma Higurashi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
University Hospital ◽  
Iron Level ◽  
Inadequate Response ◽  
Serum Iron Level ◽  
Median Serum ◽  
Iron Binding Capacity

AbstractObjectiveTo evaluate the association between iron metabolism indicators and disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19).DesignTwo-center observational studySettingA university hospital and a core hospital in Yokohama, JapanPatientsAdults with COVID-19 whose serum iron levels were measured within the first 5 days of hospitalization were included. Patients who refused mechanical ventilation were excluded from the study.Measurements and Main ResultsOne hundred thirty-six patients were included in this study. We analyzed the association between COVID-19 severity and serum iron, total iron binding capacity (TIBC), and transferrin saturation (TSAT) levels. Disease severity was defined as the worst respiratory status during hospitalization. Serum iron levels were significantly lower in patients with mild respiratory failure (RF) (n=55, median serum iron level: 24 [interquartile range: 19–42] mg/dL) than in the non-RF group (n=44, 40 [24–80] mg/dL) and the severe RF group (n=37, 60 [23.5–87] mg/dL); however, there were no significant differences in iron levels between the non-RF and severe RF groups (non-RF vs. mild RF: p=0.019, non-RF vs. severe RF: p>0.999, and mild RF vs. severe RF: p=0.009). That is, there was a U-shaped association between serum iron levels and disease severity. TIBC levels decreased significantly with increasing severity; consequently, TSAT was significantly higher in patients with severe RF than in other patients. Multivariate analysis including only patients with RF adjusted for age and sex demonstrated that higher serum iron or TSAT levels were independently associated with development of severe RF.ConclusionsA U-shaped association between serum iron level and RF severity in hospitalized COVID-19 patients was observed. Higher serum iron levels in COVID-19 patients with RF are associated with the development of severe RF, indicating that inadequate response to lower serum iron might be an exacerbating factor for COVID-19.

Evaluation of serum iron and iron binding capacity in cows with paratuberculosis

2009 ◽  
Vol 37 (06) ◽  
pp. 375-378 ◽  
Author(s):  
Z. Metcitoglu ◽  
M. Ulgen ◽  
E. Borum ◽  
E. Temizel ◽  
S. Kasap ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Serum Iron ◽  
Binding Capacity ◽  
Control Group ◽  
Iron Level ◽  
Iron Binding ◽  
Serum Iron Level ◽  
Haematological Values ◽  
Mycobacterium Avium Subsp Paratuberculosis ◽  
Iron Binding Capacity

Summary Objective: The purpose of the study was to evaluate the results of routine haematological, serum iron and iron binding capacity analyses in cattle with Mycobacterium avium subsp. paratuberculosis (MAP) infection. Material and methods: Thirty-eight cows were included in the study. An ELISA for MAP, intradermal Johnin test and microscopic examination of the animals faecal smears for acid fast organisms were performed. According to the results 19 cows (4–8 years old) were found positive and 19 cows (4–7 years old) from the same herd were negative and served as control group. In all cows routine haematological values as well as serum iron level and iron binding capacity were evaluated. Results: When compared with control animals, routine haematological values including haematocrit, haemoglobin and erythrocyte counts were significantly (p < 0.05) lower in positive cows. Also serum iron level (p < 0.01) and iron binding capacity (p < 0.01) were significantly lower in positive cows than in the control group. Conclusion: As a result, these parameters can be important for the mechanism of the pathogenesis of paratuberculosis.

scholarly journals The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kentaro Tojo ◽  
Yoh Sugawara ◽  
Yasufumi Oi ◽  
Fumihiro Ogawa ◽  
Takuma Higurashi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Level ◽  
Inadequate Response ◽  
Lower Serum ◽  
Serum Iron Level ◽  
Iron Binding Capacity

AbstractCoronavirus disease 2019 (COVID-19) is an emerging infectious disease that leads to severe respiratory failure (RF). It is known that host exposure to viral infection triggers an iron-lowering response to mitigate pathogenic load and tissue damage. However, the association between host iron-lowering response and COVID-19 severity is not clear. This two-center observational study of 136 adult hospitalized COVID-19 patients analyzed the association between disease severity and initial serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) levels. Serum iron levels were significantly lower in patients with mild RF than in the non-RF group; however, there were no significant differences in iron levels between the non-RF and severe RF groups, depicting a U-shaped association between serum iron levels and disease severity. TIBC levels decreased significantly with increasing severity; consequently, TSAT was significantly higher in patients with severe RF than in other patients. Multivariate analysis including only patients with RF adjusted for age and sex demonstrated that higher serum iron and TSAT levels were independently associated with the development of severe RF, indicating that inadequate response to lower serum iron might be an exacerbating factor for COVID-19.

Influence of hepcidin on iron homeostasis during last trimester of gestation in Bos indicus (cattle)

2019 ◽  
Author(s):  
K. Rajamanickam ◽  
M. Sameer Ali ◽  
V. Leela
Keyword(s):  
Serum Iron ◽  
Iron Homeostasis ◽  
Binding Capacity ◽  
Colorimetric Method ◽  
Maternal Serum ◽  
Iron Bioavailability ◽  
Iron Level ◽  
Iron Binding ◽  
Serum Iron Level ◽  
Iron Binding Capacity

Hepcidin is an important hormone regulating the systemic iron bio-availability. Blood samples were collected from thirty pregnant cattle during their last trimester of pregnancy to assess the relation of hepcidin to iron homeostasis. Serum hepcidin level was quantified using ELISA and serum iron, transferrin iron binding capacity and unsaturated iron binding capacity were estimated by colorimetric method. Correlation between hepcidin and other iron related parameters was assessed. Dependency of serum iron level on hepcidin was also determined by regression method. It was revealed that hepcidin was negatively correlated to serum iron and transferrin iron binding capacity (p less than 0.001) and also hepcidin has highest predictive value on serum iron level and transferrin iron binding capacity (p less than 0.001). It can be concluded that during pregnancy increase in hepcidin reduces the maternal serum iron and also it is a biomarker for iron bioavailability to the developing fetus.

scholarly journals Refractory Sideropenic Anemia in Childhood Due to an Error of Iron Metabolism

Blood ◽  
1955 ◽  
Vol 10 (12) ◽  
pp. 1246-1255 ◽  
Author(s):  
ROLF ZETTERSTRÖM ◽  
SIMONE DELAVA
Keyword(s):  
Iron Metabolism ◽  
Slow Rate ◽  
Alimentary Tract ◽  
Binding Capacity ◽  
Intravenous Iron ◽  
Iron Level ◽  
Serum Iron Level ◽  
Plummer Vinson Syndrome ◽  
Intravenous Iron Therapy ◽  
Iron Binding Capacity

Abstract Two cases of essential hypochronic anemia in childhood are reported. One of the cases which developed a mild Plummer-Vinson syndrome was completely refractory to peroral as well as intravenous iron therapy. In both cases the iron metabolism has been studied by means of radioiron. The following characteristics were found: The serum iron level was extremely low but the iron binding capacity was normal. The absorption of iron from the alimentary tract was defective and intravenously injected radioiron was utilized for hemoglobin synthesis at a slow rate. There was a rapid plasma iron turnover. The hypothesis is offered that the cause of the anemia resided in an abnormality in the regulation of iron metabolism.

scholarly journals Deferoxamine inhibition of malaria is independent of host iron status.

1988 ◽  
Vol 168 (1) ◽  
pp. 375-387 ◽  
Author(s):  
C Hershko ◽  
T E Peto
Keyword(s):  
Iron Status ◽  
Transferrin Saturation ◽  
Direct Interaction ◽  
Intracellular Iron ◽  
Intact Cells ◽  
Labile Iron Pool ◽  
Peak Parasitemia ◽  
Labile Iron ◽  
Iron Pool

The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei. Peak parasitemia was 32.6% (day 14) in untreated controls and 0.15% (day 7) in rats receiving 0.33 mg/g in 8 hourly DF injections, subcutaneously. DF inhibition of parasite growth was achieved without any reduction in transferrin saturation or hemoglobin synthesis and with only a partial (56%) depletion of hepatic iron stores. Dietary iron depletion resulted in anemia (hematocrit 25 vs. 46%), microcytosis (MCV 54 vs. 60 fl), and reduced transferrin saturation (17 vs. 96%) without any effect on infection (peak parasitemia 30 vs. 36%). Similarly, parenteral iron loading with ferric citrate over 10 d (75 mg iron/kg) failed to aggravate infection. In a search for evidence of direct interaction between DF and parasitized erythrocytes, gel filtration and ultrafiltration was performed on hemolysates obtained from in vivo 59Fe-labeled parasitized erythrocytes. This showed that 1.1-1.9% of the intracellular radioiron was located in a chelatable, labile iron pool. Incubation of intact cells with 0-500 microM DF resulted in a proportional increase in intracellular iron chelation, and the chelation of all available labile intracellular iron was completed within 6 h. These observations indicate that the severity of P. berghei infection in rats and its in vivo suppression by DF are independent of host iron status and suggest that DF inhibition of malaria involves intracellular chelation of a labile iron pool in parasitized erythrocytes.

scholarly journals TMT Quantitative Proteomics Analysis Reveals the Effects of Transport Stress on Iron Metabolism in the Liver of Chicken

Animals ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 52
Author(s):  
Jun Liu ◽  
Dunhua Liu ◽  
Xun Wu ◽  
Cuili Pan ◽  
Shuzhe Wang ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Binding Capacity ◽  
Interaction Network ◽  
Proteome Analysis ◽  
Iron Level ◽  
Liver Iron ◽  
Serum Iron Level ◽  
Liver Iron Content ◽  
Transport Stress ◽  
Iron Binding Capacity

Abnormal iron metabolism can cause oxidative stress in broilers, and transport stress (TS) may potentially influence iron metabolism. However, the mechanisms by which TS affects iron metabolism are unclear. This study used quantitative proteome analysis based on tandem mass tag (TMT) to investigate the effects of TS on liver iron metabolism in broilers. Broilers (n = 24) reared under the same conditions were selected randomly into the transported group for 4 h (T2) and non-transported group (T1). Results showed that the serum iron level and total iron-binding capacity of broilers in the T2 were significantly higher than those in the T1 (p < 0.05). The liver iron content of broilers in the T2 (0.498 ± 0.058 mg·gprot−1) was significantly higher than that in the T1 (0.357 ± 0.035 mg·gprot−1), and the iron-stained sections showed that TS caused the enrichment of iron in the liver. We identified 1139 differentially expressed proteins (DEPs). Twelve DEPs associated with iron metabolism were identified, of which eight were up-regulated, and four were down-regulated in T2 compared with T1. Prediction of the protein interaction network for DEPs showed that FTH1, IREB2, and HEPH play vital roles in this network. The results provide new insights into the effects of TS on broilers’ liver iron metabolism.

scholarly journals CHANGES IN THE PARAMETERS OF IRON METABOLISM IN RATS’ BLOOD UNDER DECIMETRIC ELECTROMAGNETIC RADIATION

2019 ◽  
Vol 64 (3) ◽  
pp. 274-282
Author(s):  
M. T. Abbasova ◽  
A. M. Gadzhiev
Keyword(s):  
Electromagnetic Radiation ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Control Group ◽  
Lipid Hydroperoxides ◽  
Iron Binding ◽  
Decimeter Range ◽  
Iron Binding Capacity ◽  
And Control

Introduction. The intensive development of radio and electrical communications, as well as various electronic devices, leads to the electromagnetic pollution of the environment.Aim. In this work, the authors set out to study the serum iron parameters of rats exposed to chronic electromagnetic radiation (EMR) of the decimeter range.Materials and methods. The research was carried out on rats that were divided into experimental and control groups. The experimental group was further divided into 4 subgroups of 10 animals each, which were subsequently exposed to electromagnetic radiation at a frequency of 460 MHz (Volna-2 apparatus) for 1, 2, 3 and 4 weeks. The control group (10 rats) was exposed to pretend irradiation, with the device being turned off. The following parameters were estimated: serum iron (SI), total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) of serum, transferrin saturation (TS), as well as serum concentrations of transferrin, haptoglobin, malondialdehyde and lipid hydroperoxides.Results. Differences in the SI concentration were found in the subgroups of animals exposed to radiation for 3 and 4 weeks (44.1 ± 3.1 μmol/l and 56.8 ± 4.4 μmol/l, respectively), as compared to the control group (30.5 ± 3.3 μmol/l). In experimental animals, TIBC increased by 41 % (p <0.05) — relative to the control group (110.8 ± 10.1 μmol/l) — only following 3 weeks of irradiation (156.2 ± 18.2 μmol/l), with a decrease in TIBC to 123.6 ± 16.4 μmol/l being noted during the 4th week. The concentration of transferrin increased from 45.6 ± 8.0 μmol/l (control) to 81.0 ± 11.5 μmol/l during the 3rd week of radiation exposure, with a decrease to 55.9 ± 6.7 μmol/l being observed during the 4th week. TS increased from 27.5 % (control) to 45.9 % only following 4 weeks of irradiation. The content of lipid hydroperoxides and malondialdehyde in the blood of irradiated rats was higher, as compared to the control animals. The serum concentration of haptoglobin amounted to 26.7 % in the control group, reaching 53.8 mg % and 47.8 mg % following 3 and 4 weeks of exposure, respectively.Conclusion. The total chronic exposure to decimetric EMR produces an oxidising effect on organisms. 

scholarly journals Iron status of Libyan infants with urinary tract infection

1999 ◽  
Vol 5 (2) ◽  
pp. 344-349
Author(s):  
Z. El Foghy ◽  
F. Sagher ◽  
S. Al Agili
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Control Group ◽  
Total Iron Binding Capacity ◽  
Iron Binding Capacity

Serum iron, serum total iron binding capacity and transferrin saturation levels were measured in 45 infants, of whom 19 had urinary tract infections confirmed by positive suprapubic aspiration. The control group comprised 26 healthy infants with negative results. Mean serum iron and transferrin saturation values were significantly lower in infants with urinary tract infection compared with the control group [P < 0.01 and P < 0.001 respectively], especially if the cultured organism was Escherichia coli [P < 0.01, P < 0.02]. Total iron binding capacity was within the normal range. We conclude that iron deficiency is not a major factor in the etiopathogenesis of urinary tract infection in Libyan infants

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