scholarly journals Adenosine deaminase activity in blood of patients with stable angina pectoris.

1997 ◽  
Vol 44 (2) ◽  
pp. 359-361 ◽  
Author(s):  
M Kopff ◽  
I Zakrzewska ◽  
J Klem ◽  
J Kalinowska-Fuchs ◽  
M Strzelczyk
Keyword(s):  
Angina Pectoris ◽  
Blood Plasma ◽  
Adenosine Deaminase ◽  
Normal Level ◽  
Stable Angina ◽  
Control Group ◽  
Stable Angina Pectoris ◽  
Adenosine Deaminases ◽  
Adenosine Deaminase Activity

The activity of adenosine deaminases (EC.3.5.4.4) in granulocytes and lymphocytes of patients with stable angina pectoris was lower by about 27% and 24%, respectively as compared with control group, whereas these values in erythrocytes and blood plasma were at the normal level.

scholarly journals Psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris

2017 ◽  
pp. 36-41
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Angina Pectoris ◽  
Autonomic Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Depression And Anxiety ◽  
Chronic Cerebral Ischemia ◽  
Stable Angina Pectoris ◽  
Personal Anxiety ◽  
High Level

The article presents the results of the study of the state of the autonomic nervous system and the psychoemotional state in patients with chronic cerebral ischemia (CCI) against the background of stable angina pectoris II and III FС. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted research and conclusions are given. Based on the findings, it was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients. We can assume that autonomic dysfunction is one of the mechanisms for the progression of stable angina pectoris in patients with CCI.

Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris

2020 ◽  
Author(s):  
Mustafa Duran ◽  
Deniz Elcik ◽  
Mehmet T Inanc ◽  
Mikail Yarlıoglues ◽  
Ibrahim E Celik ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Renal Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Stable Angina Pectoris ◽  
Number Of Patients ◽  
Study Results ◽  
Artery Disease

Aim: We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60. Materials & methods: A total of 634 (317 patients with vessel stenosis ≥50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 were included in the present study. Results: The mean eGFR was lower (95.3 ± 23.7 vs 109.7 ± 22.3, respectively, p = 0.002) and the number of patients with MRD was higher in patients with CAD (137, 43.2%) than in the control group (52, 16.4%, p < 0.001). The multivariate analysis showed that lower eGFR is an independent risk factor for presence of CAD in people under 60 with stable angina pectoris. Conclusion: According to our retrospective study, the risk of developing CAD appears to be slightly increased in individuals under 60 with MRD.

scholarly journals Comparison of Buyang Huanwu Granules and Naoxintong Capsules in Treatment of Stable Angina Pectoris: Rationale and Design of a Randomized, Double-blind, Multicenter Clinical Trial

2021 ◽  
Author(s):  
Yu Wang ◽  
Yuhan Xu ◽  
Ling Zhang ◽  
Shuwei Huang ◽  
Liping Dou ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Intervention Group ◽  
Control Group ◽  
Efficacy Rate ◽  
Efficacy And Safety ◽  
Multicenter Clinical Trial ◽  
Stable Angina Pectoris ◽  
Pharmaceutical Therapy

Abstract Background: Stable angina pectoris (SAP) is seriously threatened the health of human life currently, and the mortality is in a continuous rising stage. The current treatment strategies mainly include pharmaceutical therapy and revascularization. In China, Buyang Huanwu granules (BYHW) and Naoxintong capsule (NXT) have been used in the treatment of SAP, but it is not clear which one is better in terms of relieving symptoms and improving quality of life. Therefore, we design a clinical trial to compare the efficacy and safety between NXT and BYHW in the treatment of SAP. Methods: This is a randomized, double-blinded, parallel controlled, multicenter clinical trial protocol. On the basis of western medicine standardized treatment, a total of 128 SAP patients will be randomly divided into intervention group 1 (NXT group), intervention group 2 (BYHW group) and control group (placebo group) at a 2:1:1 ratio. A 2-week run-in period is required prior to randomization, and 1-week baseline period and 4-week treatment period are included in this study. The primary outcome is the efficacy rate of stable angina symptom score improvement; the secondary outcomes include the effect of electrocardiogram, Seattle Angina Questionnaire scores, and the nitroglycerin consumption. Discussion: This study will evaluate the efficacy and safety between NXT and BYHW in the treatment of SAP. The results will provide critical evidence of the Chinese herbal medicine for SAP. Trial registration: Chinese Clinical Trials Registry ChiCTR1800015191. Registered on 13 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25818

scholarly journals The analysis of comparative characteristics of assessment of psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris

2018 ◽  
pp. 21-26
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Angina Pectoris ◽  
Autonomic Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Depression And Anxiety ◽  
Chronic Cerebral Ischemia ◽  
Stable Angina Pectoris ◽  
Personal Anxiety ◽  
High Level

The analysis of comparative characteristics of assessment of psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris: 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients.

scholarly journals Features of bioelectric activity of the brain in patients with chronic cerebral ischemia

2017 ◽  
pp. 38-42
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Stable Angina Pectoris ◽  
Bioelectric Activity ◽  
Amplitude Analysis ◽  
Vascular Walls ◽  
The Brain

The main risk factors for cardiovascular disease are arterial hypertension, elevated levels of cholesterol and glucose in the blood, smoking, overweight, physical inertia, which is a frequent clinical manifestation of chronic cerebral ischemia, taking into account changes in the structure of the vascular walls, rheological properties of the blood, microcirculation violation. The purpose of the study was to study the features of bioelectric activity of the brain by performing frequency-amplitude analysis of parameters of the main EEG rhythms in patients with chronic cerebral ischemia on the background of angina pectoris. The article describes the features of bioelectric activity and magnetic resonance imaging (brain in patients with chronic cerebral ischemia on the background of stable angina pectoris II and III FС), 90 subjects (61 and 29 women) (mean age 60.6 ± 7.8 years) of the main group and 30 persons (10 men and 20 women) (average age - 55.2.6 ± 5.5 years) in the control group at the age from 45 to 74. The data of the conducted comprehensive neuroimaging examination of patients with chronic cerebral ischemia on the background of stable angina pectoris On the basis of data obtained using neuroimaging techniques, it was found that in patients with chronic cerebral ischemia, against the background of stable angina pectoris, the course of the disease is associated with the risk of stroke.

Modulation of Plasma Fibrinogen Levels by Ticlopidine in Healthy Volunteers and Patients with Stable Angina Pectoris

1996 ◽  
Vol 76 (02) ◽  
pp. 166-170 ◽  
Author(s):  
Moniek P M de Maat ◽  
Alf E R Arnold ◽  
Stef van Buuren ◽  
J H Paul Wilson ◽  
Cornells Kluft
Keyword(s):  
Angina Pectoris ◽  
Healthy Volunteers ◽  
Acute Phase ◽  
Stable Angina ◽  
Gene Polymorphisms ◽  
Acute Phase Reaction ◽  
Plasma Fibrinogen ◽  
Phase Reaction ◽  
Stable Angina Pectoris ◽  
Lowering Effect

SummaryElevated plasma fibrinogen levels are associated with an increased risk for cardiac events. Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. The mechanism of this decrease has not yet been elucidated and therefore mechanisms that are known to affect fibrinogen levels were studied, viz. the acute phase reaction, total fibrin plus fibrinogen degradation (TDP) levels and the polymorphisms of the fibrinogen β-gene.The fibrinogen lowering effect of ticlopidine was studied in 26 healthy volunteers, selected on genotype of the BclI polymorphism of the fibrinogen β-gene, and in 26 patients with stable angina pectoris in a double blind, randomized cross-over study. Functional plasma fibrinogen levels were measured with the Clauss assay. Fibrinogen antigen, C-reactive protein (CRP) and TDP levels were measured using an enzyme immuno assay (EIA).In the healthy volunteers the functional fibrinogen levels had decreased by 0.20 g/l (9%, p = 0.005 using the paired Student t-test) after 4 weeks of 250 mg bid ticlopidine administration, whereas fibrinogen antigen, CRP and TDP levels were not significantly changed. In the stable angina pectoris patients the pre-treatment fibrinogen, CRP and TDP levels were significantly higher than in the volunteer group. After four weeks 250 mg bid ticlopidine administration the functional fibrinogen levels had decreased by 0.38 g/l (11%, p < 0.005), whereas the fibrinogen antigen, CRP and TDP levels were not significantly changed. The levels of functional and antigen fibrinogen, CRP and TDP did not change significantly during the placebo period in the volunteers or the patients. Neither in the volunteers nor in the patients was the effect of ticlopidine on the fibrinogen levels associated with the fibrinogen β-gene polymorphisms.Therefore, the fibrinogen lowering effect of ticlopidine is likely to be a modulation of the functionality of the molecule and unlikely to be modulated by the acute phase reaction, TDP-levels or the fibrinogen β-gene polymorphisms.

Treatment of stable angina pectoris. „Mother Courage and her children”

2008 ◽  
Vol 149 (7) ◽  
pp. 291
Author(s):  
Viktor Nagy ◽  
István Czuriga
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris
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