Fabrication of TiO2-Carbon Paste Modified Electrochemical Sensor for 4-Aminophenol in Pharmaceutical Samples

2016 ◽  
Vol 32 (1-2) ◽  
pp. 58 ◽  
Author(s):  
Gidey Bahre ◽  
Tadele Hunde ◽  
Mekonen Tirfu ◽  
Rishi Pal ◽  
R. C. Saini
Keyword(s):  
Quantitative Determination ◽  
Limit Of Detection ◽  
Modified Carbon Paste Electrode ◽  
Neutral Medium ◽  
Carbon Paste ◽  
Peak Current ◽  
Pharmaceutical Samples ◽  
Square Wave ◽  
Modified Sensor

In this study the electrochemical behavior of 4-aminophenol at titanium dioxide modified carbon paste electrode was investigated using cyclic voltammetry. The working parameters for both, cyclic- and square wave- voltametric studies have been optimized using 5.0 mM 4-aminophenol (4-APOH) in 0.1 M NaH<sub>2</sub>PO<sub>4</sub>.2H<sub>2</sub>O buffer solution. The modified rather than unmodified carbon paste sensor, in neutral medium, has exhibited strong electro-catalytic activity towards the redox characteristics of 4-aminophenol by showing two-fold peak current enhancement and 174 mV peak potential shift towards negative direction. The red-ox peak current ratio (I <sub>pa</sub>/I <sub>pc</sub> = 1.6) suggested high accumulation efficiency of 4-APOH at the modified sensor. The redox process is quasi reversible and involves the transference of 2e<sup>-</sup>s and 2H<sup>+</sup>s followed by diffusion controlled, non-adsorptive behavior of 4-APOH on the surface of sensor at the interface. Further, the electro-catalytic behavior of the modified sensor has been exploited for quantitative determination of 4-aminophenol in pharmaceutical samples using square wave voltammetry. Under optimal experimental conditions, there was a linear relationship between peak current and concentration in the range 2.5 × 10<sup>-5</sup> to 2.0 × 10<sup>-4</sup> M with a correlation coefficient of 0.998 and limit of detection 1.38 × 10<sup>-8</sup> M. The method was successfully applied for the quantitative determination of 4-aminophenol in pharmaceutical formulations against the commercial drugs <em>viz</em>., <em>PANADOL</em>, and <em>Paracetamol</em> at recovery level of 100 ± 1.7 %.

scholarly journals A zeolite modified carbon paste electrode based on copper exchanged clinoptilolite nanoparticles for voltammetric determination of metronidazole

RSC Advances ◽  
2017 ◽  
Vol 7 (23) ◽  
pp. 14247-14253 ◽  
Author(s):  
Elahe Shahnazari-Shahrezaie ◽  
Alireza Nezamzadeh-Ejhieh
Keyword(s):  
Carbon Paste Electrode ◽  
Voltammetric Determination ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Peak Current ◽  
Paste Electrode

Modified carbonpaste elelctrode with Cu(ii)-exchanged clinoptilolite nanoparticles showed increased peak current in the presence of metronidazole.

scholarly journals Square wave anodic stripping voltammetric determination of Hg(II) with N-p- chlorophenylcinnamohydroxamic acid modified carbon paste electrode

2020 ◽  
Vol 34 (1) ◽  
pp. 25-39
Author(s):  
Denekew Alemayehu ◽  
Bhagwan Singh Chandravanshi Chandravanshi ◽  
Tesfu Hailu ◽  
Merid Tessema
Keyword(s):  
Carbon Paste Electrode ◽  
Anodic Stripping Voltammetry ◽  
Open Circuit ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Square Wave ◽  
Relative Standard ◽  
Anodic Stripping ◽  
Paste Electrode

A new method has been developed for the electrochemical determination of Hg(II) with N-p-chlorophenylcinnamohydroxamic acid (CPCHA) modified carbon paste electrode by square wave anodic stripping voltammetry (SWASV). Hg(II) was accumulated on the electrode surface by the formation of the complex in an open circuit and the resulting surface was characterized by electrochemical reduction and stripping. The optimum voltammetric response was observed using a carbon paste composition of 7.5% (w/w) CPCHA and preconcentration time of 210 s in 0.1 M sodium acetate at pH 8 followed by electrochemical SWASV in 0.3 M NH4Cl solution at pH 4 at a reduction potential of -0.6 V. The voltammetric signals were linear in the range of 1-25 µM Hg(II) with a detection limit of 12.9 nM. The voltammetric response for six replicate measurements of 15 µM Hg(II) was reproduced with 3.8% relative standard deviation (RSD). Many coexisting metal ions had little or no effect on the determination of Hg(II). Five spiked samples of water were evaluated by using the developed method giving recoveries of Hg(II) in the range 98-105%.   Bull. Chem. Soc. Ethiop. 2020, 34(1), 25-39. DOI: https://dx.doi.org/10.4314/bcse.v34i1.3

Voltammetric study of secnidazole and its determination in pharmaceutical tablet using 1, 4-benzoquinone modified carbon paste electrode

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Limit Of Quantification ◽  
Pharmaceutical Tablet ◽  
Relative Standard ◽  
Paste Electrode

In this study voltammetric behaviour of secnidazole (SCZ) at 1, 4-Benzoquinone Modified Carbon Paste Electrode (1,4-BQMCPE) was investigated in Britton Robinson buffer solution using cyclic voltammetric technique. A well-defined cathodic peak was observed for the SCZ in the entire pH range. The current increases steadily with scan rate and the results indicated that the process is irreversible reduction and adsorption controlled. The number of electrons transferred and different kinetic parameters like transfer coefficient and rate constant were calculated by using cyclic voltammetry technique. Differential pulse voltammetric method has been used for the determination of SCZ content in pharmaceutical tablet. This method enabled to determine SCZ in the concentration range 1.0 × 10-8 to 4.0 × 10-4 M. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 2.13 × 10-9 and 2.85 × 10-9 respectively. The method was applied to determine the content of SCZ in different sample solutions of SCZ tablet with excellent recovery and relative standard deviation results (99.892±1.53 respectively) for spiked standard SCZ in tablet sample solutions. The selectivity of the method for SCZ was further studied in the presence of selected potential interferents such as fluconazole, azithromycin etc and confirmed the potential applicability of the developed method for the determination of SCZ in real pharmaceutical tablets.

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