scholarly journals Tobacco-induced changes to Porphyromonas gingivalis gene expression, phenotype and host-pathogen interactions.

2010 ◽  
Author(s):  
Juhi Bagaitkar
Keyword(s):  
Gene Expression ◽  
Porphyromonas Gingivalis ◽  
Host Pathogen Interactions ◽  
Expression Phenotype ◽  
Gene Expression Phenotype ◽  
Host Pathogen ◽  
Induced Changes

Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology

2007 ◽  
Vol 292 (2) ◽  
pp. L367-L377 ◽  
Author(s):  
Joost B. Vos ◽  
Nicole A. Datson ◽  
Klaus F. Rabe ◽  
Pieter S. Hiemstra
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Large Scale ◽  
Brain Research ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Host Pathogen Interactions ◽  
Epithelial Surface ◽  
Complex Interactions ◽  
Host Pathogen

The epithelial surface of the airways is the largest barrier-forming interface between the human body and the outside world. It is now well recognized that, at this strategic position, airway epithelial cells play an eminent role in host defense by recognizing and responding to microbial exposure. Conversely, inhaled microorganisms also respond to contact with epithelial cells. Our understanding of this cross talk is limited, requiring sophisticated experimental approaches to analyze these complex interactions. High-throughput technologies, such as DNA microarray analysis and serial analysis of gene expression (SAGE), have been developed to screen for gene expression levels at large scale within single experiments. Since their introduction, these hypothesis-generating technologies have been widely used in diverse areas such as oncology and brain research. Successful application of these genomics-based technologies has also revealed novel insights in host-pathogen interactions in both the host and pathogen. This review aims to provide an overview of the SAGE and microarray technology illustrated by their application in the analysis of host-pathogen interactions. In particular, the interactions between epithelial cells in the human lungs and clinically relevant microorganisms are the central focus of this review.

scholarly journals Gene Expression-Phenotype Associations in Adults with Eosinophilic Esophagitis

2017 ◽  
Vol 152 (5) ◽  
pp. S29
Author(s):  
Evan S. Dellon ◽  
Sara R. Selitsky ◽  
Robert M. Genta ◽  
Richard H. Lash ◽  
Joel S. Parker
Keyword(s):  
Gene Expression ◽  
Eosinophilic Esophagitis ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals Gene expression profiling in human neutrophils after infection with Acinetobacter baumannii in vitro

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242674
Author(s):  
María Lázaro-Díez ◽  
Itziar Chapartegui-González ◽  
Borja Suberbiola ◽  
J. Gonzalo Ocejo-Vinyals ◽  
Marcos López-Hoyos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acinetobacter Baumannii ◽  
Protein Quantification ◽  
Effector Proteins ◽  
Human Neutrophils ◽  
Host Pathogen Interactions ◽  
Proinflammatory Response ◽  
Host Pathogen ◽  
Key Aspects

Acinetobacter baumannii is a Gram negative nosocomial pathogen that has acquired increasing worldwide notoriety due to its high antibiotic resistance range and mortality rates in hospitalized patients. Therefore, it is necessary to better understand key aspects of A. baumannii pathogenesis such as host-pathogen interactions. In this report, we analyzed both gene expression and cytokine production by human neutrophils infected with A. baumannii. Our assays reveal a proinflammatory response of neutrophils after A. baumannii infection, since intracellular transcription of effector proteins such as COX-2, transcription factors, and proinflammatory cytokines resulted significantly upregulated in neutrophils infected by A. baumannii, compared with unstimulated human neutrophils. Translation and release of CXCL-8, IL-1β and TNF-α by neutrophils was confirmed by protein quantification in culture supernatants. Results obtained in this report reinforce the importance of human neutrophils in controlling A. baumannii infections but also emphasize the proinflammatory nature of these host-pathogen interactions as a target for future immunomodulatory therapies.

scholarly journals Characterization of Porphyromonas gingivalis sialidase and disruption of its role in host–pathogen interactions

Microbiology ◽  
2019 ◽  
Vol 165 (11) ◽  
pp. 1181-1197 ◽  
Author(s):  
Andrew M. Frey ◽  
Marianne J. Satur ◽  
Chatchawal Phansopa ◽  
Kiyonobu Honma ◽  
Paulina A. Urbanowicz ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Host Pathogen Interactions ◽  
Host Pathogen

scholarly journals Gene expression-phenotype associations in adults with eosinophilic esophagitis

2018 ◽  
Vol 50 (8) ◽  
pp. 804-811 ◽  
Author(s):  
Evan S. Dellon ◽  
Sara R. Selitsky ◽  
Robert M. Genta ◽  
Richard H. Lash ◽  
Joel S. Parker
Keyword(s):  
Gene Expression ◽  
Eosinophilic Esophagitis ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals Nonlinear gene expression‐phenotype relationships contribute to variation and clefting in the A/WySn mouse

2019 ◽  
Vol 248 (12) ◽  
pp. 1232-1242 ◽  
Author(s):  
Rebecca M. Green ◽  
Courtney L. Leach ◽  
Virginia M. Diewert ◽  
Jose David Aponte ◽  
Eric J. Schmidt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Phenotype ◽  
Gene Expression Phenotype
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