scholarly journals Participation of mouse DNA polymerases iota, eta, and rev1 in translesion synthesis of carcinogen induced DNA adducts and carcinogenesis.

2007 ◽  
Author(s):  
Chad Dumstorf
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis

Frameshifts and deletions during in vitro translesion synthesis past Pt–DNA adducts by DNA polymerases β and η

DNA Repair ◽  
2002 ◽  
Vol 1 (12) ◽  
pp. 1003-1016 ◽  
Author(s):  
Ekaterina Bassett ◽  
Alexandra Vaisman ◽  
Kristen A. Tropea ◽  
Chad M. McCall ◽  
Chikahide Masutani ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis

Translesion Synthesis past Equine Estrogen-Derived 2‘-Deoxycytidine DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2004 ◽  
Vol 43 (35) ◽  
pp. 11312-11320 ◽  
Author(s):  
Naomi Suzuki ◽  
Manabu Yasui ◽  
Y. R. Santosh Laxmi ◽  
Haruo Ohmori ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

Translesion Synthesis Past Estrogen-Derived DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2004 ◽  
Vol 43 (20) ◽  
pp. 6304-6311 ◽  
Author(s):  
Naomi Suzuki ◽  
Shinji Itoh ◽  
Kinning Poon ◽  
Chikahide Masutani ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

scholarly journals Translesion Synthesis Past Tamoxifen-Derived DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2006 ◽  
Vol 45 (39) ◽  
pp. 12167-12174 ◽  
Author(s):  
Manabu Yasui ◽  
Naomi Suzuki ◽  
Y. R. Santosh Laxmi ◽  
Shinya Shibutani
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

scholarly journals Translesion Synthesis acrossO6-Alkylguanine DNA Adducts by Recombinant Human DNA Polymerases

2006 ◽  
Vol 281 (50) ◽  
pp. 38244-38256 ◽  
Author(s):  
Jeong-Yun Choi ◽  
Goutam Chowdhury ◽  
Hong Zang ◽  
Karen C. Angel ◽  
Choua C. Vu ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

Effect of DNA Polymerases and High Mobility Group Protein 1 on the Carrier Ligand Specificity for Translesion Synthesis past Platinum−DNA Adducts†

Biochemistry ◽  
1999 ◽  
Vol 38 (34) ◽  
pp. 11026-11039 ◽  
Author(s):  
Alexandra Vaisman ◽  
Susan E. Lim ◽  
Steve M. Patrick ◽  
William C. Copeland ◽  
David C. Hinkle ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
High Mobility ◽  
High Mobility Group ◽  
Ligand Specificity ◽  
High Mobility Group Protein ◽  
Group Protein

scholarly journals Translesion Synthesis Past Equine Estrogen-Derived 2‘-Deoxyadenosine DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2006 ◽  
Vol 45 (19) ◽  
pp. 6187-6194 ◽  
Author(s):  
Manabu Yasui ◽  
Y. R. Santosh Laxmi ◽  
Sreenivasa R. Ananthoju ◽  
Naomi Suzuki ◽  
Sung Yeon Kim ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

scholarly journals Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae

2018 ◽  
Vol 8 (2) ◽  
pp. 754-754
Author(s):  
Likui Zhang ◽  
Yanchao Huang ◽  
Xinyuan Zhu ◽  
Yuxiao Wang ◽  
Haoqiang Shi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Polymerase Δ

scholarly journals DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Richard G. Federley ◽  
Louis J. Romano
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Adducts ◽  
Structural Changes ◽  
Dna Polymerases ◽  
Conformational Dynamics ◽  
Three Dimensional ◽  
Structural Homology ◽  
Human Right ◽  
Selection Of

DNA replication is vital for an organism to proliferate and lying at the heart of this process is the enzyme DNA polymerase. Most DNA polymerases have a similar three dimensional fold, akin to a human right hand, despite differences in sequence homology. This structural homology would predict a relatively unvarying mechanism for DNA synthesis yet various polymerases exhibit markedly different properties on similar substrates, indicative of each type of polymerase being prescribed to a specific role in DNA replication. Several key conformational steps, discrete states, and structural moieties have been identified that contribute to the array of properties the polymerases exhibit. The ability of carcinogenic adducts to interfere with conformational processes by directly interacting with the protein explicates the mutagenic consequences these adducts impose. Recent studies have identified novel states that have been hypothesised to test the fit of the nascent base pair, and have also shown the enzyme to possess a lively quality by continually sampling various conformations. This review focuses on the homologous structural changes that take place in various DNA polymerases, both replicative and those involved in adduct bypass, the role these changes play in selection of a correct substrate, and how the presence of bulky carcinogenic adducts affects these changes.

The Efficiency of Translesion Synthesis Past Single Styrene Oxide DNA Adducts in Vitro Is Polymerase-Specific

1995 ◽  
Vol 8 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Gary J. Latham ◽  
Constance M. Harris ◽  
Thomas M. Harris ◽  
R. Stephen Lloyd
Keyword(s):  
Dna Adducts ◽  
Styrene Oxide ◽  
Translesion Synthesis
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