scholarly journals Association between cigarette smoking and ovarian reserve among women seeking fertility treatment with effect modification by race and NAT2 genotype.

2018 ◽  
Author(s):  
Islamiat Oladipupo
Keyword(s):  
Cigarette Smoking ◽  
Ovarian Reserve ◽  
Effect Modification ◽  
Fertility Treatment ◽  
Nat2 Genotype

scholarly journals Cigarette Smoking and Renal Cell Carcinoma Risk among Black and White Americans: Effect Modification by Hypertension and Obesity

2012 ◽  
Vol 21 (5) ◽  
pp. 770-779 ◽  
Author(s):  
Michele L. Cote ◽  
Joanne S. Colt ◽  
Kendra L. Schwartz ◽  
Sholom Wacholder ◽  
Julie J. Ruterbusch ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cigarette Smoking ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Effect Modification ◽  
White Americans ◽  
Black And White ◽  
Carcinoma Risk

scholarly journals Association Between Cigarette Smoking and Ovarian Reserve Among Women Seeking Fertility Care

2021 ◽  
Author(s):  
Islamiat Oladipupo ◽  
T'shura Ali ◽  
David W Hein ◽  
Kelly Pagidas ◽  
Henry Bohler ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Smoking Status ◽  
Effect Modification ◽  
Diminished Ovarian Reserve ◽  
Self Report ◽  
Tobacco Smoke Exposure ◽  
Heavy Smoking ◽  
Current Smoking Status ◽  
Current Smoking ◽  
Increased Risk

Abstract Background This study examined the association of smoking with ovarian reserve in a cross-sectional study of 207 women enrolled in the Louisville Tobacco Smoke Exposure, Genetic Susceptibility, and Infertility (LOUSSI) Study and assessed effect modification by NAT2 acetylator phenotype. Methods Information on current smoking status was collected using a structured questionnaire and confirmed by cotinine assay. Serum anti-Müllerian hormone (AMH) levels were used to assess ovarian reserve. Diminished ovarian reserve (DOR) was defined as AMH < 1ng/mL. Single nucleotide polymorphisms in the NAT2 gene, which metabolizes toxins found in cigarette smoke, were analyzed to determine NAT2 acetylator status. Linear and logistic regression were used to determine the effects of smoking on ovarian reserve and evaluate effect modification by NAT2. Regression analyses were stratified by polycystic ovary syndrome (PCOS) status and adjusted for age. Results Current smoking status, either passive or active, was not significantly associated with DOR. For dose-response assessed using self-report, the odds of DOR increased significantly for every additional cigarette currently smoked (odds ratio, OR:1.08; 95% confidence interval, 95%CI:1.01–1.15); additionally, every 1 pack-year increase in lifetime exposure was associated with an increased odds of DOR among women without PCOS (OR: 1.08 95%CI: 0.99–1.18). These trends appear to be driven by the heavy or long-term smokers. Effect modification by NAT2 genotype was not established. Conclusion A history of heavy smoking, but not current smoking status, may indicate increased risk of diminished ovarian reserve.

scholarly journals Effects of melatonin on ovarian reserve in cigarette smoking: an experimental study

2020 ◽  
Vol 16 (6) ◽  
pp. 1376-1386
Author(s):  
Emre Kole ◽  
Sebiha Ozkan ◽  
Ceyla Eraldemir ◽  
Furuzan Akar ◽  
Sema Ozbek ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cigarette Smoking ◽  
Ovarian Reserve

Abstract B51: Effect modification of the relationship between cigarette smoking and endometrial carcinoma risk

2013 ◽  
Author(s):  
Ashley S. Felix ◽  
Hannah P. Yang ◽  
Gretchen L. Gierach ◽  
Yikyung Park ◽  
Louise A. Brinton
Keyword(s):  
Cigarette Smoking ◽  
Endometrial Carcinoma ◽  
Effect Modification ◽  
The Relationship ◽  
Carcinoma Risk

scholarly journals Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

2019 ◽  
Vol 91 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Susan Peters ◽  
Anne E Visser ◽  
Fabrizio D'Ovidio ◽  
Jelle Vlaanderen ◽  
Lützen Portengen ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Smoking Status ◽  
Disease Onset ◽  
Population Based ◽  
Pooled Analysis ◽  
Effect Modification ◽  
Case Control Studies ◽  
Alcohol Education ◽  
Logistic Regression Models ◽  
Quitting Smoking

BackgroundWe investigated the association between cigarette smoking and risk of amyotrophic lateral sclerosis (ALS) in a pooled analysis of population-based case–control studies and explored the independent effects of intensity, duration and time-since-quitting.MethodsALS cases and controls, matched by age, sex and region, were recruited in the Netherlands, Italy and Ireland (*Euro-MOTOR project). Demographics and detailed lifetime smoking histories were collected through questionnaires. Effects of smoking status, intensity (cigarettes/day), duration (years), pack-years and time-since-quitting (years) on ALS risk were estimated using logistic regression models, adjusting for age, sex, alcohol, education and centre. We further investigated effect modification of the linear effects of pack-years by intensity, duration and time-since-quitting using excess OR (eOR) models.ResultsAnalyses were performed on 1410 cases and 2616 controls. Pack-years were positively associated with ALS risk; OR=1.26 (95% CI: 1.03 to 1.54) for the highest quartile compared with never smokers. This association appeared to be predominantly driven by smoking duration (ptrend=0.001) rather than intensity (ptrend=0.86), although the trend for duration disappeared after adjustment for time-since-quitting. Time-since-quitting was inversely related to ALS (ptrend<0.0001). The eOR decreased with time-since-quitting smoking, until about 10 years prior to disease onset. High intensity smoking with shorter duration appeared more deleterious than lower intensity for a longer duration.ConclusionsOur findings provide further support for the association between smoking and ALS. Pack-years alone may be insufficient to capture effects of different smoking patterns. Time-since-quitting appeared to be an important factor, suggesting that smoking may be an early disease trigger.

scholarly journals Alcohol, cigarette smoking, and ovarian reserve in reproductive-age African-American women

2016 ◽  
Vol 215 (6) ◽  
pp. 758.e1-758.e9 ◽  
Author(s):  
Leah Hawkins Bressler ◽  
Lia A. Bernardi ◽  
Peter John D. De Chavez ◽  
Donna D. Baird ◽  
Mercedes R. Carnethon ◽  
...  
Keyword(s):  
African American ◽  
Cigarette Smoking ◽  
African American Women ◽  
Ovarian Reserve ◽  
Reproductive Age ◽  
American Women
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