scholarly journals Awareness of executive functioning as a diagnostic tool for mild cognitive impairment and Alzheimer's disease.

2015 ◽  
Author(s):  
Jeremy Carmasin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functioning ◽  
Diagnostic Tool

Memory Patterns and Executive Functioning in Mild Cognitive Impairment and Alzheimer's Disease

2002 ◽  
Vol 9 (4) ◽  
pp. 288-297 ◽  
Author(s):  
Timothy A. Crowell ◽  
Cheryl A. Luis ◽  
Rodney D. Vanderploeg ◽  
John A. Schinka ◽  
Michael Mullan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functioning

scholarly journals p-tau/Aβ42 Ratio Associates with Cognitive Decline in Alzheimer’s disease, Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults

2020 ◽  
Author(s):  
Ruchika Shaurya Prakash ◽  
Michael R. McKenna ◽  
Oyetunde Gbadeyan ◽  
Rebecca Andridge ◽  
Douglas W. Scharre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functioning ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Cognitive Functioning ◽  
The Impact

AbstractINTRODUCTIONThe most well-studied biomarkers in AD are CSF amyloid beta-42 (Aβ42), tau, p-tau, and the ratio p-tau/Aβ42. The ratiometric measure of p-tau/Aβ42 shows the best diagnostic accuracy, and correlates reliably with metrics of cognition in unimpaired participants. However, no study has examined the impact of the CSF p-tau/Aβ42 ratio in predicting cognitive decline in both healthy and AD individuals in one sample. The goal of this study was to examine whether CSF-based p-tau/Aβ42 predicts changes in global cognitive functioning, episodic memory, and executive functioning over a two-year period in cognitively impaired older adults (CU), and in individuals with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD).METHODSThis study involves secondary analysis of data from 1215 older adults available in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Neuropsychological variables, collected at baseline, 6-month, 12-month, and 24-month follow-ups, included the Preclinical Alzheimer’s Cognitive Composite (PACC) to assess global cognitive functioning, ADNI-MEM to assess episodic memory functioning, and ADNI-EF to assess executive functioning. Linear mixed models were constructed to examine the effect of CSF p-tau/Aβ42, diagnostic group, and change over time (baseline, 6-month, 12-month, and 24-month) on cognitive scores.RESULTSCSF p-tau/Aβ42 ratios predicted worsening cognitive impairment, both on global cognition and episodic memory in individuals with MCI and AD, but not in CU older adults and predicted decline in executive functioning for all three diagnostic groups.DISCUSSIONOur study, including CU, MCI, and AD individuals, provides evidence for differential cognitive consequences of accumulated AD pathology based on diagnostic groups.

Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive functioning

2011 ◽  
Vol 23 (8) ◽  
pp. 1327-1333 ◽  
Author(s):  
Rosa L. Drijgers ◽  
Frans R. J. Verhey ◽  
Albert F. G. Leentjens ◽  
Sebastian Köhler ◽  
Pauline Aalten
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Neuropsychological Functioning ◽  
Linear Regression Analysis ◽  
Neuropsychological Correlates ◽  
Neuropsychiatric Diseases

ABSTRACTBackground: Apathy is a common and important behavioral syndrome in various neuropsychiatric diseases, such as mild cognitive impairment (MCI) and Alzheimer's disease (AD). So far, only few studies have compared the neuropsychological correlates of apathy in patients with MCI and dementia. The aim of the current study was to examine the association between apathy and neuropsychological functioning in patients with MCI and AD.Methods: Two-hundred-and-sixty AD patients and 178 MCI patients visiting the Memory Clinic of the Maastricht University Medical Centre participated in the study. Linear regression analysis, corrected for age, gender, level of education and depression, was performed to reveal cross-sectional associations between apathy and scores on neuropsychological tests of memory, attention, psychomotor speed and executive functioning.Results: In patients with MCI, apathy was characterized by decreased verbal fluency and psychomotor tracking. In AD, patients with apathy differed from non-apathetic patients only on a verbal fluency task.Conclusion: Apathy is related to executive dysfunction in the early phases of cognitive decline. In particular, in the prodromal phase of AD, apathy seems to be characterized by poor initiating. In the more advanced stages of cognitive deterioration, associations between apathy and specific neuropsychological correlates may be obscured by the more severe neuropathology. Awareness of apathy in the early phase of cognitive impairment may help in early diagnosis of AD.

[P1-492]: ASSOCIATION BETWEEN THEORY OF MIND AND EXECUTIVE FUNCTIONING IN MILD COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE AND HEALTHY OLDER ADULTS

2017 ◽  
Vol 13 (7S_Part_9) ◽  
pp. P478-P479
Author(s):  
Daniel Alejandro Lopez Ramos ◽  
Gilberto Isaac Acosta-Castillo ◽  
Juan Francisco Flores-Vazquez ◽  
Yaneth Rodriguez Agudelo ◽  
Ana Luisa Sosa-Ortiz
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Theory Of Mind ◽  
Executive Functioning ◽  
Healthy Older Adults
Sign in / Sign up

Export Citation Format

Share Document