scholarly journals PACAP : a novel neuropeptide for pituitary gonadotroph maturation, function and regulation.

2013 ◽  
Author(s):  
Rongqiang Yang
Keyword(s):  
Maturation Function

The male gamete: spermatogenesis, maturation, function

2011 ◽  
pp. 1336-1347
Author(s):  
C. Marc Luetjens ◽  
Gerhard F. Weinbauer
Keyword(s):  
Male Gamete ◽  
Testicular Function ◽  
Sexual Hormones ◽  
Local Regulation ◽  
Experimental Animals ◽  
Male Gametes ◽  
Function Data ◽  
Maturation Function

The testes fulfil two essential functions: the production and maturation of the male gametes and synthesis and the secretion of the sexual hormones. Unless otherwise specified, this chapter describes the situation in the human and provides the basis for understanding the endocrine and local regulation of testicular function. Data obtained in experimental animals are presented when the corresponding human mechanisms are not known or cannot be clarified for ethical reasons.

The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function

Bone ◽  
2001 ◽  
Vol 28 (5) ◽  
pp. 513-523 ◽  
Author(s):  
V Rajapurohitam ◽  
N Chalhoub ◽  
N Benachenhou ◽  
L Neff ◽  
R Baron ◽  
...  
Keyword(s):  
Lethal Mutation ◽  
Maturation Function

scholarly journals Robotic QM/MM-driven maturation of antibody combining sites

2016 ◽  
Vol 2 (10) ◽  
pp. e1501695 ◽  
Author(s):  
Ivan V. Smirnov ◽  
Andrey V. Golovin ◽  
Spyros D. Chatziefthimiou ◽  
Anastasiya V. Stepanova ◽  
Yingjie Peng ◽  
...  
Keyword(s):  
Immune Response ◽  
In Vitro Selection ◽  
Single Point ◽  
Combinatorial Libraries ◽  
Single Point Mutation ◽  
Wild Type ◽  
Selection Of ◽  
Maturation Function

In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely mimic the full mammalian immune response. We approached this goal using quantum mechanics/molecular mechanics (QM/MM) calculations to achieve maturation in silico. We preselected A17, an Ig template, from a naïve library for its ability to disarm a toxic pesticide related to organophosphorus nerve agents. Virtual screening of 167,538 robotically generated mutants identified an optimum single point mutation, which experimentally boosted wild-type Ig scavenger performance by 170-fold. We validated the QM/MM predictions via kinetic analysis and crystal structures of mutant apo-A17 and covalently modified Ig, thereby identifying the displacement of one water molecule by an arginine as delivering this catalysis.

The impact of pre-existing radial artery pathology by histological assessment on the maturation, function and patency of the radiocephalic fistula for hemodialysis

2019 ◽  
Vol 38 (3) ◽  
Author(s):  
Ramon Roca-Tey ◽  
Ramon Bordes ◽  
Román Martínez-Cercós ◽  
Amelia Rivas ◽  
Amparo Roda ◽  
...  
Keyword(s):  
Radial Artery ◽  
Histological Assessment ◽  
The Impact ◽  
Maturation Function

scholarly journals Preclinical contraceptive development for men and women

2020 ◽  
Vol 103 (2) ◽  
pp. 147-156
Author(s):  
Daniel S Johnston ◽  
Erwin Goldberg
Keyword(s):  
Hormonal Contraception ◽  
Hormonal Contraceptives ◽  
Development Programs ◽  
Target Validation ◽  
Preclinical Development ◽  
Men And Women ◽  
Academic Environments ◽  
Pros And Cons ◽  
To Come ◽  
Maturation Function

Abstract This manuscript endeavors to present research considerations for the preclinical development of non-hormonal contraceptives. Topics include (1) how advances in genomics and bioinformatics impact the identification of novel targets for non-hormonal contraception, (2) the importance of target validation prior to investment in a contraceptive development campaign, (3) considerations on targeting gametogenesis vs gamete maturation/function, (4) how targets from the male reproductive system are expanding women’s options for ‘on demand’ contraception, and (5) some emerging non-hormonal methods that are not based on a specific molecular target. Also presented are ideas for developing a pipeline of non-hypothalamic-pituitary-gonadal-acting contraceptives for men and women while balancing risk and innovation, and our perspective on the pros and cons of industry and academic environments on contraceptive development. Three product development programs are highlighted that are biologically interesting, innovative, and likely to influence the field of contraceptive development in years to come.

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