This chapter describes how novice international faculty and scholars in American universities may face formidable challenges related to their new responsibilities and the cultural demands as they begin their tenure-track careers in the academe. Upon completion of the doctorate programs, some find themselves in organizations that have unfamiliar cultures and expectations. Regardless of their background, nationality or experience, they are expected to maintain the trademarks of teaching, scholarship, advisement, and community service in order to survive the rigor of academe. Unfortunately, the reality is often more overwhelming for international faculty and scholars because of multifaceted acculturation issues that are related to their new country and organization. Mentors can serve as facilitators for novice faculty. Through teamwork, mentors and novice faculty members can construct knowledge and create a culture of collaboration. It is envisioned that cross- culturally sensitive mentoring can help to ease the challenges of the new faculty as they navigate their unfamiliar environment in the academe.