A study of cutaneous adverse drug reactions among HIV infected adults in a tertiary care centre in north Karnataka

2020 ◽  
Vol 6 (4) ◽  
pp. 366-373
Author(s):  
Kiran ◽  
◽  
Shilpa Vinay Dastikop ◽  
Sushruth Kamoji ◽  
Rohith ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Care Centre ◽  
Drug Reactions ◽  
Tertiary Care Centre

scholarly journals STUDY TO EVALUATE SEVERE ADRS IN A TERTIARY CARE TEACHING HOSPITAL

2017 ◽  
pp. 55-58
Author(s):  
A. R. Malahat ◽  
C. Deepa Latha ◽  
Sudhakar K. ◽  
Deepika Baloju ◽  
G. Vijayalakshmi
Keyword(s):  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Prospective Observational Study ◽  
Healthcare Professionals ◽  
Tertiary Care ◽  
Care Centre ◽  
Drug Reactions ◽  
Tertiary Care Centre ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching

Objective: This study attempts to analyze the severe ADRs in a tertiary care centre and assess their seriousness, outcome, causality and severity. We emphasize on the need for reporting of ADRs by all healthcare professionals as it will reduce the burden of morbidity due to drugs and ensure better and more efficient healthcare. To analyse and evaluate the severe ADVERSE DRUG REACTIONs reported from various departments in a Tertiary care Teaching hospital.Methods: It is a prospective observational study that was carried out over a period of 6 mo (from July 2016 to December 2016) to assess the percentage of severe adverse drug reactions reported to the Pharmacovigilance cell of a tertiary care teaching hospital. The data collected included patient’s demographic details, presenting complaints, clinical diagnosis and details of the drug(s) prescribed. The data was analysed for causality (as per the WHO-UMC scale) and severity (as per Hartwig and Siegel scale).Results: Out of 64 ADRs reported, 17 were serious. The majority of serious ADRs were categorized as probable (82.35%), whilst 1(5.8%) was categorized as possible and 2(11.76%) as certain in nature. The criteria for the majority of serious ADRs were hospitalization (%) followed by intervention to prevent permanent impairment or damage (%).Conclusion: The highest percentage of severe cases was reported with Antitubercular therapy (23.5%) followed by analgesics (23%) and anti epileptic agents (17.6%).

scholarly journals Evaluation of adverse drug reactions of first line antiretroviral drugs in a tertiary care centre of Telangana, India

2018 ◽  
Vol 7 (11) ◽  
pp. 2091
Author(s):  
Padmaja Gabbita ◽  
Margaret V. Jillapegu ◽  
Saikiran L. N. Vangala ◽  
Jahnavi Tiruveedhula
Keyword(s):  
Adverse Event ◽  
Adverse Events ◽  
Adverse Drug Reactions ◽  
Antiretroviral Treatment ◽  
Tertiary Care ◽  
Antiretroviral Drugs ◽  
Treatment Center ◽  
Drug Reactions ◽  
First Line ◽  
Tertiary Care Centre

Background: The introduction of highly active anti-retroviral therapy (HAART) has led to a significant reduction in AIDS related morbidity and mortality. Most of the adverse drug reactions are preventable. So continuous evaluation will benefit Antiretroviral treatment that helped to achieve ultimate goal of making treatment safer and more effective to patients. The present study was designed to monitor and analyse the incidence, type and nature of adverse events to first line Antiretroviral drugs.Methods: A cross sectional observational study was conducted at Antiretroviral treatment center of Gandhi Hospital, Secunderabd, Telangana. The study was conducted over a period of 6 months involving all HIV patients. After initiation of 1st line regimen- tenofovir 300mg + lamivudine 300mg + efavirenz 600mg (TLE), patients were followed for any adverse event. Descriptive statistics was used for analysis of data.Results: Out of 453 studied, 47 patients developed adverse events. A total of 79 adverse events were reported. The assessment of total adverse drug reaction profile revealed cutaneous 44.30%, hematological 40.50%, renal 11.39%, gastrointestinal 3.79%. WHO-UMC causality assessment scale showed 76.5% and 23.4% Adverse events as probable and possible respectively. Hartwig and Siegel severity scale revealed 93.6%, 2.1% and 4.3% as mild, moderate and severe cases respectively.Conclusions: The TLE regimen found with lower adverse events in this study. The study focuses the importance of active adverse event monitoring to detect early toxicities and to support safe use of anti-retroviral treatment.

scholarly journals A retrospective study of Adverse Drug Reactions in a tertiary care centre

2018 ◽  
Vol 7 (7) ◽  
pp. 1339
Author(s):  
V. J. Ambika Abhishake ◽  
S. Basalingappa ◽  
Arun Gopi ◽  
More Pankaj Daulat
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Unintended Effects ◽  
Age Group ◽  
Test Results ◽  
Drug Reactions ◽  
Tertiary Care Centre ◽  
Common System ◽  
Males And Females

Background: Adverse drug reactions (ADRs) are a major concern in present day clinical practice. They are inevitable consequences of drug therapy; as no pharmacotherapeutic agent is completely free from noxious and unintended effects. They are major contributors for morbidity, mortality and hospitalization of the patients increasing the economic burden on the society and uncertainty in clinical outcomes.Methods: This was a retrospective observational study, extending over 6 months (September 2016 to February 2017). A total of 290 cases were studied, excluding the geriatric age group. The data was collected using CDSCO ADR reporting form. A comparison of ADR between males and females was made; based on the organ system affected and the category of drug using “proportion test”.Results: The study showed the ADR incidence was equal in both sexes (≈50%). It was observed that majority ADRs were from gastro intestinal system (39%) followed by CNS (20%) and skin and soft tissue (14%). Constipation was found to be the most common of the reported ADRs (18%) followed by vomiting (9%) and diarrhoea (8%).Conclusions: ADRs are a major cause of morbidity worldwide. Several studies; including the present one, has shown GIT to be the most common system affected. Frequency of ADRs can be reduced by careful follow up and a robust hospital based pharmacovigilance setup.

EVALUATION OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE CENTER IN SOUTH INDIA-A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
pp. 1-3
Author(s):  
Laila KV ◽  
Fathima Habeeba TE ◽  
Mohamed Musthafa A ◽  
Jobin Louis ◽  
Madeeha Habeebulla ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Prospective Observational Study ◽  
Spontaneous Reporting ◽  
Drug Class ◽  
Care Center ◽  
Tertiary Care ◽  
Drug Reactions ◽  
Tertiary Care Centre ◽  
Males And Females ◽  
Reporting Method

Aim:To Evaluate the Adverse Drug Reactions among patients attending a tertiary care centre. Materials and Methods: Aprospective spontaneous reporting method of Adverse Drug Reaction (ADR) in hospitalised setting was conducted for a period of six months. Results: The study came across with the demography of patients, the most commonly involved classes of drugs and assessment of ADRs. The results showed that 136 adverse drug reactions were reported from a total of 11584 patients and the overall incidence of ADR calculated from patient population was 0.81%. No signicant difference was seen in overall incidence of ADRs observed in males and females. Incidence of ADRs among adults (1.15%) was signicantly higher than paediatrics and geriatrics. Antibiotics (39.71%) were the drug class most commonly associated with ADRs. Causality assessment states that majority of the reported ADRs were probable according to WHO-UMC criteria. According to the severity assessment majority of the ADRs were mild in nature. Most of the ADRs were not preventable (76.47%) according to Schumock and Thornton preventability scale. Conclusion: ADR monitoring was found to be useful to measure the effectiveness and safe use of medication.

scholarly journals Hospitalization due to Adverse Drug Reactions and Drug Interactions before and after HAART

2000 ◽  
Vol 11 (4) ◽  
pp. 193-201 ◽  
Author(s):  
Michelle M Foisy ◽  
Kevin Gough ◽  
Corinna M Quan ◽  
Kevin Harris ◽  
Dominique Ibanez ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Highly Active Antiretroviral Therapy ◽  
Phase 1 ◽  
Tertiary Care ◽  
Retrospective Chart Review ◽  
Partial Recovery ◽  
Phase 2 ◽  
Drug Reactions ◽  
Tertiary Care Centre ◽  
The Mean

OBJECTIVE: To characterize and compare the rates of adverse drug reactions (ADRs) and interactions on admission in two, one-year periods: pre-highly active antiretroviral therapy (HAART) (phase 1) and post-HAART (phase 2).DESIGN: Retrospective chart review.SETTING:University-affiliated tertiary care centre.POPULATION STUDIED: HIV-positive patients admitted to hospital.MAIN RESULTS: In phase 1, 436 of 517 admissions, and, in phase 2, 323 of 350 admissions were analyzed. Over 92% of patients were male, with a mean age of 38 years. Significant differences (P<0.05) in the mean length of stay (12.08 versus 10.02 days), the CD4 counts (99.25 versus 129.45) and the number of concurrent diseases (4.20 versus 3.63) were found between phase 1 and 2, respectively. The mean number of medications taken (5.52 versus 5.94) and the rates of hospitalization with ADRs (20.4% versus 21.4%) or interactions (2.5% versus 2.16%) were similar between the two phases. Antiretrovirals were more common in ADR admissions post-HAART (21.3% versus 36.2%), while antiparasitics, psychotherapeutics and antineoplastics were more common pre-HAART. Other classes of drugs involved in both phases were sulphonamides, narcotics, ganciclovir, foscarnet, antimycobacterials and antifungals. ADR causality was possible or probable in more than 80% of cases. Over 60% of ADRs were grades 3 to 4, and about 85% were either the main or contributing reason for admission. About 65% of patients had at least partial recovery at the time of discharge. In phases 1 and 2, 8.9% and 2.9% of admissions,respectively, with ADRs were fatal.CONCLUSIONS: Although hospitalizations with ADRs and interactions were similar in both phases, HAART therapy has had a significant impact on the incidence and nature of ADRs at St Michael?s Hospital, Wellesley Central Site, Toronto, Ontario.

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