scholarly journals To evaluate the efficacy of dexmedetomidine infusion versus fentanyl infusion for sedation during awake fibreoptic intubation (AFOI)

2020 ◽  
Vol 7 (2) ◽  
pp. 233-237
Author(s):  
Ashwini Rajesh Sonsale ◽  
◽  
Jyoti Kale ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Jyrson Guilherme Klamt ◽  
Walter Villela de Andrade Vicente ◽  
Luis Vicente Garcia ◽  
Cesar Augusto Ferreira

Background. The purpose of this study was to access the effects of dexmedetomidine-fentanyl infusion on blood pressure (BP) and heart rate (HR) before surgical stimulation, on their changes to skin incision, and on isoflurane requirement during cardiac surgery in children.Methods. This study had a prospective, randomized, and open-label design. Thirty-two children aged 1 month to 10 years undergoing surgery for repair congenital heart disease (CHD) with CPB were randomly allocated into two groups: group MDZ received midazolam 0.2 mg·kg−1·h−1and group DEX received dexmedetomidine 1 g·kg−1·h−1during the first hour followed by half of these rates of infusions thereafter. Both group received fentanyl 10 g·kg−1, midazolam 0.2 mg·kg−1and vecuronium 0.2 mg·kg−1for induction. These same doses of fentanyl and vecuronium were infused during the first hour then reduced to half. The infusions started after induction and maintained until the end of surgery. Isoflurane was given briefly to control hyperdynamic response to skin incision and sternotomy.Results. In both groups, systolic blood pressure (sBP) and heart rate (HR) decreased significantly after one hour of infusion of the anesthetic solutions, but there were significantly less increase in diastolic blood pressure, sBP, and HR, and less patients required isoflurane supplementation to skin incision in the patients of the DEX group.Discussion. Dexmedetomidine infusion without a bolus appears to be an effective adjunct to fentanyl anesthesia in control of hemodynamic responses to surgery for repair of CHD in children.


Anaesthesia ◽  
2000 ◽  
Vol 55 (8) ◽  
pp. 816-817 ◽  
Author(s):  
W. R. Garrett ◽  
M. B. Hough

2021 ◽  
Vol 14 (2) ◽  
pp. e238600
Author(s):  
Ming Kai Teah ◽  
Esther Huey Ring Liew ◽  
Melvin Teck Fui Wong ◽  
Tat Boon Yeap

Awake fibreoptic intubation (AFOI) is an established modality in patients with anticipated difficulty with tracheal intubation. This case demonstrates that with careful and meticulous preparations, AFOI can lead to improved airway management and excellent patient outcomes. A 38-year-old woman presented with severe trismus secondary to odentogenous abscess was identified preoperatively as having a potential difficult airway. AFOI was performed successfully using combined Spray-As-You-Go and dexmedetomidine technique.


Author(s):  
Ting Li ◽  
Tongtong Liu ◽  
Meihong Li ◽  
Chuanhan Zhang ◽  
Wenlong Yao

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seongsu Kim ◽  
Soo Jung Park ◽  
Sang Beom Nam ◽  
Suk-Won Song ◽  
Yeonseung Han ◽  
...  

AbstractDexmedetomidine has emerged as a promising organ protective agent. We performed prospective randomized placebo-controlled trial investigating effects of perioperative dexmedetomidine infusion on pulmonary function following thoracic aortic surgery with cardiopulmonary bypass and moderate hypothermic circulatory arrest. Fifty-two patients were randomized to two groups: the dexmedetomidine group received 1 µg/kg of dexmedetomidine over 20 min after induction of anesthesia, followed by 0.5 µg/kg/h infusion until 12 h after aortic cross clamp (ACC)-off, while the control group received the same volume of normal saline. The primary endpoints were oxygenation indices including arterial O2 partial pressure (PaO2) to alveolar O2 partial pressure ratio (a/A ratio), (A–a) O2 gradient, PaO2/FiO2 and lung mechanics including peak inspiratory and plateau pressures and compliances, which were assessed after anesthesia induction, 1 h, 6 h, 12 h, and 24 h after ACC-off. The secondary endpoints were serum biomarkers including interleukin-6, tumor necrosis factor-α, superoxide dismutase, and malondialdehyde (MDA). As a result, dexmedetomidine did not confer protective effects on the lungs, but inhibited elevation of serum MDA level, indicative of anti-oxidative stress property, and improved urine output and lower requirements of vasopressors.


2019 ◽  
Vol 60 (3) ◽  
pp. 110-118 ◽  
Author(s):  
J Wong ◽  
JSE Lee ◽  
TGL Wong ◽  
R Iqbal ◽  
P Wong

1989 ◽  
Vol 62 (1) ◽  
pp. 13-16 ◽  
Author(s):  
A. OVASSAPIAN ◽  
T.C. KREJCIE ◽  
S.J. YELICH ◽  
M.H.M. DYKES

Anaesthesia ◽  
2009 ◽  
Vol 64 (10) ◽  
pp. 1148-1149 ◽  
Author(s):  
D. Yang ◽  
X. M. Deng ◽  
S. Y. Tong ◽  
M. P. Luo ◽  
K. L. Xu ◽  
...  

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