scholarly journals Safety and Efficacy of Aspirin Desensitization Combined With Long-Term Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease

2020 ◽  
Vol 30 (5) ◽  
pp. 327-333
Author(s):  
R Li ◽  
F Luo
Keyword(s):  
Respiratory Disease ◽  
Aspirin Therapy ◽  
Safety And Efficacy ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease

Long-term Sinonasal Outcomes of Aspirin Desensitization in Aspirin Exacerbated Respiratory Disease

2014 ◽  
Vol 151 (4) ◽  
pp. 575-581 ◽  
Author(s):  
Kyu-Sup Cho ◽  
Ethan Soudry ◽  
Alkis J. Psaltis ◽  
Kari C. Nadeau ◽  
Sean A. McGhee ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease

Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in Aspirin-exacerbated Respiratory Disease

2018 ◽  
Vol 32 (4) ◽  
pp. 280-286 ◽  
Author(s):  
Kristen M. Walters ◽  
Jeremy D. Waldram ◽  
Katharine M. Woessner ◽  
Andrew A. White
Keyword(s):  
Respiratory Disease ◽  
Average Length ◽  
Airway Disease ◽  
Sinus Surgery ◽  
Response To Treatment ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Systemic Corticosteroids ◽  
Samter’S Triad

Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter’s triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis. ASA desensitization with daily ASA therapy is a uniquely beneficial treatment for this disease entity and has been shown to have a significant impact on symptom scores, polyp disease, and need for systemic corticosteroids. However, no long-term studies have demonstrated whether or not ASA therapy remains safe and beneficial for these patients beyond 5–10 years. Objective This study was designed to determine the clinical course of AERD patients desensitized between 1995 and 2010. Methods A 20-question survey was distributed to patients who successfully completed ASA desensitization between January 1995 and April 2010. The questions were designed to assess ASA safety and longitudinal effects of ASA therapy in AERD. Results Of the 285 patients contacted, 92 (32%) completed the questionnaire. Average length of follow-up was 15 years. Of survey responders, 35 patients had discontinued ASA therapy. Although adverse reactions occurred, many also discontinued due to lack of efficacy or need for surgery. For those remaining on ASA (62%), significant improvement in sense of smell, asthma, sinus, and allergic rhinitis scores were noted ( P ≤ .001). The majority of ASA patients (68%) had a positive response to treatment and did not require further sinus surgery. However, ASA therapy did not delay the time to next sinus/polyp surgery ( P = .27) or reduce total number of sinus surgeries ( P = .56) compared to those who stopped treatment. Nearly 85% of AERD patients on ASA therapy found it to be helpful in improving airway disease and quality of life. Conclusion Aspirin desensitization followed by daily maintenance ASA therapy appears to be safe and effective even after 10+ years of continuous use.

An Update on the Epidemiology of Aspirin-Exacerbated Respiratory Disease

2017 ◽  
Vol 31 (5) ◽  
pp. 299-301 ◽  
Author(s):  
Andrew A. White
Keyword(s):  
Respiratory Disease ◽  
Diagnostic Test ◽  
Clinical Studies ◽  
Nasal Polyposis ◽  
Aspirin Therapy ◽  
Population Characteristics ◽  
Sinus Disease ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Cyclooxygenase 1 ◽  
Specific Evaluation

Background Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade. Methods AERD Warrants Specific Evaluation As An Endotype Of Asthma And Chronic Sinus Disease Due To Unique Therapeutic Opportunities. Currently, Aspirin Therapy Is Uniquely Beneficial As An Anti-Inflammatory Therapy In Aerd, With Multiple Additional Therapies Currently In Early To Late Clinical Studies, Which Might Also Show Exceptional Benefit In AERD. Results Yet, given the lack of a simple diagnostic test, opportunities to identify patients with AERD are still frequently neglected. Conclusion Identifying the prevalence and population characteristics necessary to determine appropriate candidates in whom to perform diagnostic aspirin challenge remains critically important and was the purpose of this article.

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