scholarly journals Effects of Rupatadine on Platelet- Activating Factor–Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study)

2017 ◽  
Vol 27 (3) ◽  
pp. 161-168 ◽  
Author(s):  
R Munoz-Cano ◽  
E Ainsua-Enrich ◽  
I Torres-Atencio ◽  
M Martin ◽  
J Sánchez-Lopez ◽  
...  
Keyword(s):  
Mast Cell ◽  
Platelet Activating Factor ◽  
Mast Cell Degranulation ◽  
Human Mast Cell

Effects Of Rupatadine On Platelet Activating Factor (PAF)-induced Human Mast Cell Degranulation Compared With Desloratadine And Levocetirizine

2012 ◽  
Vol 129 (2) ◽  
pp. AB122 ◽  
Author(s):  
R. Munoz-Cano ◽  
I. Torres-Atencio ◽  
E. Ainsua ◽  
M. Martin Andorra ◽  
J. Sanchez-Lopez ◽  
...  
Keyword(s):  
Mast Cell ◽  
Platelet Activating Factor ◽  
Mast Cell Degranulation ◽  
Human Mast Cell

scholarly journals Mechanisms of cell injury in rat mesentery and cremaster muscle

1998 ◽  
Vol 274 (3) ◽  
pp. H1009-H1015 ◽  
Author(s):  
A. G. Harris ◽  
J. J. Costa ◽  
F. A. Delano ◽  
B. W. Zweifach ◽  
G. W. Schmid-Schönbein
Keyword(s):  
Mast Cell ◽  
Cell Injury ◽  
Tissue Injury ◽  
Platelet Activating Factor ◽  
Random Order ◽  
Mast Cell Degranulation ◽  
Cremaster Muscle ◽  
Time Points ◽  
Rat Mesentery ◽  
Dichlorofluorescin Diacetate

The events responsible for cell injury after a tissue stimulation are only incompletely understood. The purpose of this study was to examine mechanisms of cell injury in two tissues, rat mesentery and cremaster muscle, after tissue stimulation with N-formylmethionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). The response was studied in the same animal in random order using normal and leukopenic rats. The tissues were exteriorized after pentobarbital anesthesia. Five to six vascularized areas were chosen in each tissue, and cell injury and hydroperoxide production were assessed visually by continuous superfusion with 1 μM propidium iodide and 5 μM dichlorofluorescin diacetate (DCFH), respectively. FMLP (1 × 10−8M) and then PAF (1 × 10−8M) were added to the superfusate, and measurements were made at several time points. The second tissue was then examined using the same protocol. In the cremaster, there was little hydroperoxide production, and the tissue injury was eliminated after leukopenia. Leukopenia had no effect on tissue injury in the mesentery. Although hydroperoxide production was observed, there was no correlation between it and the tissue injury. The level of preactivation showed no correlation with either tissue injury or hydroperoxide production. In light of these results, mast cell degranulation may be an important mechanism of tissue injury in the mesentery.

Human mast cell tryptase: a biochemical marker for mast cell degranulation

1989 ◽  
Vol 17 (4) ◽  
pp. 728-729 ◽  
Author(s):  
ANDREW F. WALLS ◽  
AMANDA R. BENNETT ◽  
HARRY M. McBRIDE ◽  
MARTIN J. GLENNIE ◽  
STEPHEN T HOLGATE ◽  
...  
Keyword(s):  
Mast Cell ◽  
Biochemical Marker ◽  
Mast Cell Degranulation ◽  
Human Mast Cell ◽  
Mast Cell Tryptase

The Fcεriβ Homologue, MS4A4, Promotes Fcεri-Dependent Human Mast Cell Degranulation By Facilitating PLCγ1 Signaling

2015 ◽  
Vol 135 (2) ◽  
pp. AB240 ◽  
Author(s):  
Glenn Cruse ◽  
Michael A. Beaven ◽  
Stephen C. Music ◽  
Peter Bradding ◽  
Dean D. Metcalfe
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation ◽  
Human Mast Cell

Ischemia/reperfusion-induced microvascular dysfunction: role of oxidants and lipid mediators

1997 ◽  
Vol 272 (6) ◽  
pp. H2976-H2982 ◽  
Author(s):  
I. Kurose ◽  
L. W. Argenbright ◽  
R. Wolf ◽  
L. Lianxi ◽  
D. N. Granger
Keyword(s):  
Superoxide Dismutase ◽  
Mast Cell ◽  
Ischemia Reperfusion ◽  
Platelet Activating Factor ◽  
Leukotriene B4 ◽  
Lipid Mediators ◽  
Mast Cell Degranulation ◽  
Albumin Leakage ◽  
Endothelial Cell Adhesion

The objective of this study was to define the role of oxidants and lipid mediators in the leukocyte-endothelial cell adhesion and albumin leakage elicited in rat mesenteric venules by ischemia-reperfusion (I/R). Intravital fluorescence microscopy was used to monitor leukocyte adherence and emigration, platelet-leukocyte aggregation, mast cell degranulation, and albumin leakage after release of a 20-min arterial occlusion. I/R elicited large increases in leukocyte-endothelial cell adhesion and albumin leakage. These responses were significantly attenuated in venules treated with either superoxide dismutase, oxypurinol (an inhibitor of xanthine oxidase), lodoxamide (a mast cell stabilizer), WEB-2086 (a platelet-activating factor antagonist), or SC-41930 (a leukotriene B4-receptor antagonist) but not by U-74006F (an inhibitor of lipid peroxidation). Platelet-leukocyte aggregates and mast cell degranulation induced by I/R were also attenuated by administration of either superoxide dismutase or lodoxamide. These results support the hypothesis that oxidants produced, in part, by xanthine oxidase promote the formation (by mast cells and endothelial cells) of platelet-activating factor and leukotriene B4, which recruit and activate leukocytes in postischemic venules. The adherent and emigrated leukocytes then mediate the increased albumin extravasation observed in the postcapillary venules.

A granular variant of CD63 is a regulator of repeated human mast cell degranulation

Allergy ◽  
2010 ◽  
Vol 65 (10) ◽  
pp. 1242-1255 ◽  
Author(s):  
T. Schäfer ◽  
P. Starkl ◽  
C. Allard ◽  
R. M. Wolf ◽  
T. Schweighoffer
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation ◽  
Human Mast Cell

scholarly journals Neuropeptides activate human mast cell degranulation and chemokine production

Immunology ◽  
2008 ◽  
Vol 123 (3) ◽  
pp. 398-410 ◽  
Author(s):  
Marianna Kulka ◽  
Cecilia H. Sheen ◽  
Brian P. Tancowny ◽  
Leslie C. Grammer ◽  
Robert P. Schleimer
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation ◽  
Human Mast Cell ◽  
Chemokine Production
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