scholarly journals Development and Characterization of a Microfluidic Method for Real-Time Generation of Transiently Stable Biocompatible Microbubbles In Situ for Image-Guided Therapy

2013 ◽  
Author(s):  
Johnny Chen
2017 ◽  
Vol 250 ◽  
pp. 36-47 ◽  
Author(s):  
Koorosh Ashrafi ◽  
Yiqing Tang ◽  
Hugh Britton ◽  
Orianne Domenge ◽  
Delphine Blino ◽  
...  

Brachytherapy ◽  
2015 ◽  
Vol 14 (6) ◽  
pp. 910-912 ◽  
Author(s):  
Christian Kirisits ◽  
Maximilian P. Schmid ◽  
Sushil Beriwal ◽  
Richard Pötter

Gels ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 86 ◽  
Author(s):  
Brenda Molina ◽  
Eva Domínguez ◽  
Elaine Armelin ◽  
Carlos Alemán

In this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3. The newly developed system consists of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles, which were embedded into a poly-γ-glutamic acid (γ-PGA) biohydrogel during the gelling reaction between the biopolymer chains and the cross-linker, cystamine. After this, agglomerates of PEDOT nanoparticles homogeneously dispersed inside the biohydrogel were used as polymerization nuclei for the in situ anodic synthesis of poly(hydroxymethyl-3,4-ethylenedioxythiophene) in aqueous solution. After characterization of the resulting flexible electrode composites, their ability to load and release MeNQ was proven and monitored. Specifically, loaded MeNQ molecules, which organized in shells around PEDOT nanoparticles agglomerates when the drug was simply added to the initial gelling solution, were progressively released to a physiological medium. The latter process was successfully monitored using an electrode composite through differential pulse voltammetry. The fabrication of electroactive flexible biohydrogels for real-time release monitoring opens new opportunities for theranostic therapeutic approaches.


2000 ◽  
Author(s):  
David R. Snelling ◽  
Gregory J. Smallwood ◽  
Robert A. Sawchuk ◽  
W. Stuart Neill ◽  
Daniel Gareau ◽  
...  

Author(s):  
Tina Kapur ◽  
Jan Egger ◽  
Jagadeesan Jayender ◽  
Matthew Toews ◽  
William M. Wells

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